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Application of a sesquiterpene compound in the preparation of drugs for inhibiting acute inflammation

A technology of acute inflammation and compounds, applied in the field of medicine, can solve problems such as inflammatory diseases and body death, and achieve the effect of inhibiting lethality, broad clinical application prospects, and significant lethality.

Active Publication Date: 2018-08-10
NORTHEAST AGRICULTURAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, when the spread of inflammation and excessive response will lead to the occurrence of many non-infectious diseases, and excessive inflammatory response can also cause the occurrence of inflammatory diseases, and even lead to the death of the body

Method used

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  • Application of a sesquiterpene compound in the preparation of drugs for inhibiting acute inflammation
  • Application of a sesquiterpene compound in the preparation of drugs for inhibiting acute inflammation
  • Application of a sesquiterpene compound in the preparation of drugs for inhibiting acute inflammation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Example 1, Extraction, Separation and Identification of Albicanol in Trichofern Glandularis

[0048] experimental method:

[0049] Use tweezers to pick up a small piece of medical absorbent cotton dampened with acetone, hold down one end of Dermascens with your fingers, and wipe the entire Dermascens leaf slowly and vigorously, trying to maximize the glandular hairs. Here During the process, pay attention to changing the acetone and cotton frequently, and filter the acetone dissolved in the metabolites of glandular hairs to remove impurities. The filtered acetone solution is stored in a rotary evaporator, installed in a rotary evaporator, and evaporated in a water bath at 42°C under reduced pressure. When the acetone is evaporated to dryness, turn off the rotary switch and the water bath switch, and save the glandular hair volatile oil in the rotary evaporator. weighing. Dissolve the concentrated volatile oil of Trichofern trichomes in tetrahydrofuran and pass it on t...

Embodiment 2

[0051] Embodiment 2, the activity comparison of Albicanol anti-acute inflammatory lethality under concentration gradient treatment

[0052] experimental method:

[0053] 1. In vivo activity detection

[0054] Fifty-five Kunming mice were pre-fed with sufficient water and food for 1 week before being used in experiments and weighed daily.

[0055] Get 55 mice with normal body weight (that is, within the range of 25g-35g), divide them into 6 groups, and carry out the following parallel treatments respectively:

[0056] LPS acute inflammation model group: Give the lipopolysaccharide LPS (Sigma) solution that mouse buys once at about 9 o'clock in the morning, intraperitoneal injection, dosage is 5mg / kg (promptly according to mouse body weight, every kilogram of mouse gives the LPS of 5mg), with Adjust the injection volume to 0.2 mL with normal saline;

[0057] 25mg / kg Albicanol treatment group: Albicanol solution was given to mice once at around 9:00 a.m., intragastric administ...

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Abstract

The invention relates to an application of a sesquiterpene compound in the preparation of acute inflammation inhibition drugs, and belongs to the technical field of drugs. The sesquiterpene compound is Albicanol, and is extracted from Dryopteris fragrans. The sesquiterpene Albicanol extracted from the Dryopteris fragrans has a substantial acute inflammation fatality, and can substantially inhibit inflammation factor expression and promote body recovery.

Description

technical field [0001] The invention relates to the application of a sesquiterpene compound in the preparation of medicines for inhibiting acute inflammation, and belongs to the technical field of medicine. Background technique [0002] Inflammation is a basic pathological process of the body in response to tissue damage caused by various inflammatory stimuli, and it is also a protective response to remove harmful stimuli and repair damaged tissues. However, the spread and excessive response of inflammation will lead to the occurrence of many non-infectious diseases, and excessive inflammatory response can also cause the occurrence of inflammatory diseases, and even lead to the death of the body. Factors such as bacterial infection, tissue damage, and thrombus can all cause an inflammatory response, and in some cases even septic shock. Current anti-inflammatory drugs can be divided into glucocorticoids (such as cortisone, dexamethasone, prednisone, etc.) Two categories, bo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/045A61P29/00C07C29/76C07C33/14
CPCA61K31/045C07C29/76C07C33/14
Inventor 常缨高睿张童卜志刚
Owner NORTHEAST AGRICULTURAL UNIVERSITY
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