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Application of salvianolic acid K in sage in the preparation of drugs for preventing and treating diabetic nephropathy

Inactive Publication Date: 2018-11-16
XINJIANG MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Preliminary studies on its pharmacology have found that they have a strong inhibitory effect on aldose reductase, but there is no research on the prevention and treatment of DN by Salvianolic acid K (Salvianolic acid K) in Xinjiang sage and its mechanism of action. to report

Method used

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  • Application of salvianolic acid K in sage in the preparation of drugs for preventing and treating diabetic nephropathy
  • Application of salvianolic acid K in sage in the preparation of drugs for preventing and treating diabetic nephropathy
  • Application of salvianolic acid K in sage in the preparation of drugs for preventing and treating diabetic nephropathy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Add 6 times the mass of methanol to sage herbaceae in Xinjiang to reflux and extract 4 times, each time for 2 hours, combine the extracts, recover the solvent, and freeze-dry to obtain the extract. Pass the extract through an MCI gel column, eluting with water, 10% methanol-water, 30% methanol-water, 50% methanol-water, 70% methanol-water in sequence, concentrate respectively, and freeze-dry each concentrate , to obtain concentrated dry fractions with different ratios of methanol-water. Select 30%-70% methanol-water to concentrate and dry the part to pass through the macroporous adsorption resin, select the eluent to be 10% ethanol-water, 30% ethanol-water and 60% ethanol-water, concentrate the eluent respectively, and Each concentrate was freeze-dried to obtain concentrated dry fractions with different ethanol-water ratios. Select the concentrated dry part of 30%-60% ethanol-water, separate and purify it with SephadexLH-20, and select the eluent as 30%-50% acetonitril...

Embodiment 2

[0035] The difference between this example and Example 1 lies in: add methanol with 8 times the mass to reflux and extract 3 times, each time for 1 hour, combine the extracts, recover the solvent, and freeze-dry to obtain the extract. All the other parts are the same as in Example 1. The purity is 91%, and the extraction rate is 3.76%.

Embodiment 3

[0037] The difference between this example and Example 1 lies in: add methanol with 10 times the mass to reflux extraction twice for 3 hours each time, combine the extracts, recover the solvent, and freeze-dry to obtain the extract. All the other parts are the same as in Example 1. The purity is 90%, and the extraction rate is 3.70%.

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Abstract

The invention provides application of salvianolic acid K in salvia japonica thunb to preparation of medicine for preventing and treating diabetic nephropathy.Safety of the salvianolic acid K in the salvia japonica thunb in Sinkiang is evaluated objectively and scientifically through experiments, and a dosage basis is provided for experiment research on prevention and treatment of DN; firstly, the median lethal dose (LD 50) is determined through per os acute toxicity tests of mice, on the basis of the tests, in vivo experiments on animals are conducted, the prevention and treatment functions and possible mechanism of action of the salvianolic acid K on DN are determined, an experiment basis is provided for preventing and treating DN through natural medicine, and technical data are provided for further development and utilization of the salvia japonica thunb in Sinkiang.

Description

technical field [0001] The invention belongs to the technical field of medicine preparation, and in particular relates to the application of salvianolic acid K in salvia sage in the preparation of medicines for preventing and treating diabetic nephropathy. Background technique [0002] Diabetic nephropathy (DN) is one of the most common and serious microvascular complications of diabetes, a common cause of chronic renal insufficiency, and an important cause of death and disability in diabetic patients. The disease prevention mechanism of DN is relatively complex, how to effectively treat DN is a major problem that researchers are currently facing. There are many reports on the experimental research and clinical application of natural medicines to prevent and treat DN, and attempts to protect DN from molecular biology and gene levels have also been explored. Xinjiang sage (Salviadeserta Schang) is a plant of the genus Salvia (Labiatae) in the Labiatae family. The Latin scien...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/216A61P3/10A61P13/12C07C69/734C07C67/48
CPCA61K31/216C07C67/48C07C69/734
Inventor 热娜·卡斯木王晓梅李敏王小青穆健
Owner XINJIANG MEDICAL UNIV
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