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Phenylethyl resorcinol high-loading lipid nanocapsule and preparation method thereof

A technology of phenylethyl resorcinol lipid and phenylethylresorcinol, which is applied in the field of carrier systems in cosmetic preparation technology, can solve the problems of the stability of neroli essential oil and easily penetrate the skin into the blood system, etc. Achieve the effects of simple and controllable preparation method, high stability and improved stability

Inactive Publication Date: 2016-06-01
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Technical problem: The purpose of the present invention is to provide a lipid nanocapsule with high loading capacity of phenylethyl resorcinol and its preparation method, to produce a kind of phenylethyl resorcinol used in whitening cosmetics, to solve the problem of cosmetics The stability of neroli essential oil and its easy penetration into the blood system through the skin

Method used

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  • Phenylethyl resorcinol high-loading lipid nanocapsule and preparation method thereof
  • Phenylethyl resorcinol high-loading lipid nanocapsule and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0024] Weigh 2g caprylic / capric triglyceride, 2g acetylated monoglyceride, 2g ethoxydiglycol, 1g 1,3-butanediol, 0.1g disodium EDTA, 7g polyethylene glycol 30 dipolyhydroxystearin Ester, 7g polysorbate 80, 2g sorbitan olivate, 1g ceteareth-25 were stirred at 65°C to form a transparent solution, added 5g phenylethyl resorcinol, and the stirring speed was 300rpm, the stirring time is 6min, add 55.9g of the water phase (45.9g of glycerin and 10g of deionized water) in the same temperature water bath, stir at 300rpm / min for 8min, and then cool to obtain light yellow and transparent phenylethyl resorcinol high loading capacity Lipid nanocapsule, the particle size of the lipid nanocapsule with high loading capacity of phenethyl resorcinol is about 134nm as measured by laser particle size analyzer.

Embodiment 2

[0026] 10g Caprylic / Capric Triglyceride, 5g 1,3-Butanediol, 5g Glyceryl Monostearate, 0.5g Butyl Octyl Salicylate, 7g Macrogol 30 Dipolyhydroxystearate, 4g of soybean lecithin PC60 was stirred at 65°C to form a transparent solution, 5g of phenylethyl resorcinol was added, the stirring speed was 400rpm, the stirring time was 6min, and 63.5g of the same temperature water phase (53.5g of glycerol and 10g of deionized water ), 300rpm / min stirred 8min, after cooling obtains light yellow transparent phenylethyl resorcinol high loading lipid nanocapsule, this phenylethyl resorcinol high loading lipid nanocapsule is measured by laser particle size analyzer Its particle size is about 120nm.

Embodiment 3

[0028] Weigh 5g of caprylic / capric triglyceride, 4g of ethoxydiethylene glycol, 0.3g of butyl octanyl salicylate, 5g of soybean lecithin PC60, 10g of 1,3-dipropylene glycol and stir at 65°C to form a transparent Solution, add 5g of neroli essential oil, stirring speed is 400rpm, stirring time is 5min, add 70.7g isothermal water phase (60.7g glycerin and 10g deionized water), 350rpm / min stirs 7min, after cooling obtains pale yellow transparent styrene Resorcinol high-loading lipid nanocapsules, the particle size of the phenylethylresorcinol high-loading lipid nanocapsules is about 124nm as measured by a laser particle size analyzer.

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Abstract

The invention provides a phenylethyl resorcinol high-loading lipid nanocapsule and a preparation method thereof. The phenylethyl resorcinol high-loading lipid nanocapsule has the average particle diameter of 50-250 nm and consists of the following active ingredients by mass percent: 1-40% of phenylethyl resorcinol, 2-20% of lipid, 3-35% of an emulsifier, 2-10% of an assistant emulsifier, 0.5-5% of a stabilizer and the balance of deionized water. The phenylethyl resorcinol high-loading lipid nanocapsule is a faint yellow transparent running liquid, is high in stability, is transparent and blueing after being dispersed by 200 times of water and can be freely compounded with cosmetics. The preparation method is simple and controllable and good in repeatability.

Description

technical field [0001] The present invention relates to the technical field of carrier systems in cosmetic preparation technology, and more specifically relates to a preparation method of whitening cosmetic carrier systems, that is, lipid nanocapsules with a high loading capacity of phenylethyl resorcinol and a preparation method thereof. Background technique [0002] Phenylethylresorcinol, INCI (International Nomenclature of Cosmetic Ingredients) name is PhenylethylResorcinol, chemical name is 4-(1-phenylethyl)-1,3-benzenediol, which is a resorcinol derivative , CAS number is 85-27-8, molecular formula is C14H1402, molecular weight is 214.27, it is white crystalline solid, light smell, melting point is 78-82 ℃, it can dissolve in glycols (solubility close to 1%), but the solution is Pale pink. [0003] The whiteness or blackness of a person's skin often depends on the content and distribution of melanin in the skin. Tyrosinase is the main rate-limiting enzyme in the entir...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/14A61K8/34A61Q19/02
CPCA61K8/14A61K8/347A61K2800/413A61K2800/52A61Q19/02
Inventor 夏强邢廷康
Owner SOUTHEAST UNIV
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