Novel hemostatic material and preparation method thereof

A hemostatic material and a new type of technology, applied in the field of medical biomaterials, can solve the problems of limited kaolin particles, limited scope of use, and difficulty in subsequent processing, and achieve the effects of no sensitization, low cost, and no skin irritation.

Active Publication Date: 2016-05-11
ANHUI KESHENG BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But this kind of material still has some deficiencies, such as the limited number of kaolin particles adhered, the loading capacity is only 40-50% of the quality of the non-woven fabric as the substrate, and the particles adhered to the non-woven fabric substrate are easy to fall off. leading to the reduction of its hemostatic ability and the difficulty of subsequent treatment
At the same time, because the product is in the form of gauze, its application range is limited, especially for complex wounds such as wound shape and depth.
This product has been equipped to the US military, but due to technical barriers and the Cold War mentality, the product has not entered the domestic market

Method used

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  • Novel hemostatic material and preparation method thereof
  • Novel hemostatic material and preparation method thereof
  • Novel hemostatic material and preparation method thereof

Examples

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preparation example Construction

[0036] The technology disclosed in the present invention relates to a preparation method of a novel hemostatic material, comprising the following steps:

[0037] (1) After drying a certain amount of washed kaolin raw ore at 105°C, crush it to less than 2mm, make a 4g / L slurry with water, and add 0.6% raw ore mass (NaPO 3 ) 6 , stir and disperse for 45 minutes, naturally age for 6 hours, extract the supernatant, control the concentrate yield to 40-45%, place the concentrate rack further to separate the excess water, and dry the material to obtain the concentrate. Add the water-washed kaolin concentrate to the hydrochloric acid solution with a mass ratio of 5-30%, raise the temperature to 55-105°C under stirring, and pickle and refine for 4-24h. After solid-liquid separation, the reaction product is washed to pH 5.5-7.5, dried and pulverized. Transfer the pulverized product to a roasting furnace and roast at a temperature of 450-850°C for 1.5-4.5 hours to obtain activated kaol...

Embodiment 1

[0045] (1) Weigh 2.5kg of kaolin (provided by Maoming Kaolin Technology Co., Ltd.), dry it at 105°C, crush it to 2mm, make a 4g / L slurry with water, add 15g of (NaPO 3 ) 6 , stir and disperse for 45 minutes, naturally age for 6 hours, extract the supernatant, control the concentrate yield to 45%, place the concentrate rack further to separate excess water, and dry the material. Then slowly add it to a hydrochloric acid solution with a concentration of 5% by mass, and pickle with stirring at a temperature of 55°C for 24 hours. After solid-liquid separation, the product is washed with pure water until the pH of the washing liquid is 7.5, dried and crushed. Transfer the pickled kaolin to a roasting furnace at 450°C for 4.5 hours and set aside;

[0046] (2) Weigh 10kg of sodium acrylate solution with a mass percent concentration of 18%, adjust the pH to 4.5-7.5 with hydrochloric acid solution, add N,N-methylenebisacrylamide at 0.001% of the molar number of sodium acrylate, and s...

Embodiment 2

[0049] (1) Weigh 10kg of sodium acrylate solution with a mass percentage concentration of 18%, adjust the pH to 4.5-7.5 with hydrochloric acid solution, add 2% glycerol to the molar number of sodium acrylate, stir to fully dissolve and evenly. Add ammonium bicarbonate according to 5% of the mass of the sodium acrylate solution, and add kaolin prepared in step (1) of Example 1 at 6:1, and stir until dispersed evenly to form a slurry solution. Potassium persulfate with 5 mol% sodium acrylate was added, stirred evenly and then transferred to a polymerization kettle to initiate polymerization. After the reaction is completed, the polymer is coarsely crushed and dried in a dry environment at 125-185°C, and the first-grade product is obtained after granulation;

[0050] (2) The calcium chloride solution with a concentration of 1% by mass is evenly sprayed on the surface of the first-grade product according to the proportion of 0.8% of the first-grade product quality. After completi...

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Abstract

The invention discloses a novel hemostatic material and a preparation method thereof. The novel hemostatic material is a polymer generated by performing copolymerization-crosslinking and surface crosslinking treatment on mineral clay and acrylate, wherein mineral clay is subjected to purification, pickling purification and high-temperature activation pretreatment and serves as a main raw material. The novel hemostatic material disclosed by the invention overcomes the shortcomings of an existing commonly used hemostatic product, particularly a hemostatic material for moderate and severe wounds, and is applicable to bleeding control and first aid of the moderate and severe wounds. A test shows that the novel hemostatic material has the characteristics of high efficiency, quickness, convenience in use and low cost, does not have any side effect, is safe to a human body, and is favorable for large-area popularization and use in the future.

Description

technical field [0001] The invention belongs to the field of medical biomaterials, and in particular relates to a novel hemostatic material for realizing rapid hemostasis of moderate to severe wounds and a preparation method thereof. Background technique [0002] Massive hemorrhage refers to the massive and sudden bleeding caused by the rupture of large arteries or large veins in animals or humans caused by trauma. Hemostasis first aid for heavy bleeding caused by moderate to severe trauma has always been a difficult problem in the medical field, and it is the main cause of death from various traumas, especially in the field of pre-hospital first aid such as wars, natural disasters, traffic accidents, emergencies, etc., rapid hemostasis is even more important links. Generally speaking, the bleeding of small wounds can be suppressed by the blood's own coagulation function and some additional nursing measures. However, for moderate to severe traumatic bleeding, especially ma...

Claims

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Application Information

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IPC IPC(8): A61L15/24A61L15/44A61L15/46A61L15/18A61L33/16
Inventor 赵伟张永青陈光王来东
Owner ANHUI KESHENG BIOTECH CO LTD
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