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Method of curing nanometer resveratrol through gellan gum microspheres

A technology of resveratrol and gellan gum, which is used in cosmetics, pharmaceutical formulations, cosmetic preparations, etc., can solve the problems of low loading rate, high resveratrol loading rate, unstable self-property, etc., and achieves the loading rate high effect

Active Publication Date: 2016-05-04
东莞市星泽日用品有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The technical problem that the present invention mainly solves: because resveratrol is insoluble in water at present, self-property is unstable, easily be oxidized and decomposed under the action of light, heat etc., traditionally adopted glyceryl stearate is resveratrol The carrier easily causes particles to fuse with each other, resulting in low loading rate, agglomeration, and poor stability. A method for solidifying nano-resveratrol with gellan gum microspheres is provided. The invention first prepares gellan gum microspheres and The surface is treated, and then the nano-resveratrol particles with stable physical and chemical properties are prepared by the emulsification method, and the surface of the gellan gum microspheres is loaded on the surface of the gellan gum microspheres, so that the resveratrol can not only have a hydrophilic function, but is not easy to be oxidized and decomposed, and white The high loading rate of veratrol on the surface of gellan gum microspheres not only produces agglomeration

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0016] First weigh 100g of gellan gum and add it to a 1L three-neck flask, then add 500mL of ionized water, put it in a water bath and stir at a constant temperature of 70°C until the gellan is fully dissolved, then add oleic acid to the gellan gum solution at a volume ratio of 5:1 , stirred at 1000r / min for 10min to obtain the gellan gum / oleic acid emulsion; pour the emulsion into a 1L beaker, add 30mL of salad oil into the cup, and stir in an ice bath at 0-5°C for 15min. Put the stirred emulsion into the refrigerator at -10°C to cool and stand for 20 minutes, take it out after standing, rinse the emulsion in the beaker with a mixed solution of acetone, glycerin, and diethyl carbonate for 4 times, and put the rinsed emulsion in Dry in an oven at 65°C for 3 hours, take it out after drying, and sieve to collect 100 μm gellan gum microspheres, lightly polish the microspheres with sandpaper for surface treatment, and set aside for later use. The acetone, glycerin, and diethyl carb...

example 2

[0019]First weigh 150g of gellan gum and add it to a 1L three-neck flask, then add 550mL of ionized water, put it in a water bath and stir at a constant temperature of 75°C until the gellan is fully dissolved, then add oleic acid to the gellan gum solution at a volume ratio of 5:1 , stirred at 1100r / min for 15min to obtain the gellan gum / oleic acid emulsion; pour the emulsion into a 1L beaker, add 40mL of salad oil into the cup, and stir in an ice bath at 3°C ​​for 17min. The final emulsion was then placed in a refrigerator at -10°C for cooling and standing for 25 minutes, and then taken out after standing, the emulsion in the beaker was rinsed 5 times with a mixed solution of acetone, glycerin, and diethyl carbonate, and the rinsed emulsion was placed in 70 Dry in an oven at ℃ for 4 hours, take it out after drying, and sieve to collect 125 μm gellan gum microspheres, lightly polish the microspheres with sandpaper for surface treatment, and then use them for later use. The acet...

example 3

[0022] First weigh 200g of gellan gum and add it to a 1L three-neck flask, then add 600mL of ionized water, put it in a water bath and stir at a constant temperature of 80°C until the gellan is fully dissolved, then add oleic acid to the gellan gum solution at a volume ratio of 5:1 , stirred at 1200r / min for 20min to obtain gellan gum / oleic acid emulsion; pour the emulsion into a 1L beaker, add 50mL of salad oil into the cup, put it in an ice bath at 5°C and stir for 20min. The final emulsion was then placed in a refrigerator at -10°C to cool and stand for 30 minutes, and then taken out after standing, the emulsion in the beaker was rinsed 6 times with a mixed solution of acetone, glycerin, and diethyl carbonate, and the rinsed emulsion was placed in 75 Dry in an oven at ℃ for 5 hours, take out after drying, and sieve to collect 150 μm gellan gum microspheres, lightly polish the microspheres with sandpaper for surface treatment, and set aside for later use. The acetone, glyceri...

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Abstract

The invention discloses a method of curing nanometer resveratrol through gellan gum microspheres and belongs to the field of resveratrol. According to the method, the gellan gum microspheres are made first, the surfaces of the gellan gum microspheres are treated, an emulsification method is used for making nanometer resveratrol particles with stable physicochemical properties, and the surfaces of the gellan gum microspheres are loaded with the nanometer resveratrol particles. As a result, resveratrol has a hydrophilic function and is not prone to oxygenolysis, the loading rate of resveratrol on the surfaces of the gellan gum microspheres is high, and agglomeration will not occur.

Description

technical field [0001] The invention discloses a method for solidifying nano-resveratrol with gellan gum microspheres, belonging to the field of resveratrol. Background technique [0002] Resveratrol is a non-flavonoid polyphenolic compound containing a stilbene structure, also known as stilbene triphenols. Widely present in natural plants or fruits such as grapes, pine trees, knotweeds, cassia seeds and peanuts, mainly derived from grapes (red wine), knotweeds, peanuts, mulberries and other plants. At least 72 species of plants belonging to 21 families and 31 genera have been found so far. Resveratrol is a phytoalexin produced by many plants when they are subjected to biotic or abiotic stress (such as fungal infection, ultraviolet radiation, etc.). In addition to improving the disease resistance of plants, resveratrol has been found to have a variety of biological activities and pharmacological effects that are beneficial to human health, and has been valued by the biomed...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K31/05A61K8/02A61K8/34A61Q19/00A23L33/105A23L2/52
CPCA23L2/52A61K8/025A61K8/345A61K9/146A61K31/05A61K2800/10A61K2800/412A61K2800/413A61Q19/00
Inventor 李振宇王志慧
Owner 东莞市星泽日用品有限公司
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