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Chitin whisker/magnesium oxide whisker/biodegradable polyester composite material as well as preparation method and application thereof

A biodegradable polyester and magnesium oxide whisker technology, applied in the direction of magnesium oxide, etc., can solve the problems of insufficient mechanical strength and toughness, lack of osteoinductivity, and difficulty in live detection, achieving excellent comprehensive performance and avoiding non-infectious Inflammatory response, reducing the effect of acidic autocatalytic effect

Active Publication Date: 2016-04-20
JINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the results of clinical application over the years have shown that biodegradable polyester bone repair materials still have some shortcomings: (1) the mechanical strength and toughness of the material are not enough, and it is difficult to be used as a load-bearing bone repair; (2) the degradation rate of the material is difficult to control; (3) The weak acidity of the degradation products can easily lead to non-infectious inflammatory reactions; (4) Lack of osteoinductivity, and the ability to promote bone tissue healing is limited; (5) X-rays do not develop, and it is difficult to achieve living detection
In the Chinese publication CN103319866A, magnesium oxide whiskers are used as reinforcing and toughening fillers for biodegradable polyester, and by surface grafting lactide or polylactide to the magnesium oxide whiskers, the whisker and biodegradable polyester are improved. The interfacial compatibility of the matrix and the dispersibility of whiskers can effectively improve the mechanical properties and osteogenic activity of biodegradable polyester materials; The improvement and regulation of the degradation rate are limited, and the method of chemically grafting and modifying the surface of magnesium oxide whiskers is also cumbersome, and often requires higher reaction temperatures and the use of organic solvents

Method used

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  • Chitin whisker/magnesium oxide whisker/biodegradable polyester composite material as well as preparation method and application thereof
  • Chitin whisker/magnesium oxide whisker/biodegradable polyester composite material as well as preparation method and application thereof
  • Chitin whisker/magnesium oxide whisker/biodegradable polyester composite material as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Embodiment 1: the preparation of chitin whisker

[0048] Weigh 30g of chitin powder, put it in 3mol / L potassium hydroxide solution, stir and boil for 6h, then stir at room temperature for 24h, filter and rinse the sample; the obtained precipitate is reacted in 80°C bleaching solution for 6h, and the bleaching solution is replaced every 2h Suction filtration, the sample was washed three times, the obtained sample was placed in 3mol / L potassium hydroxide solution for 48h, then centrifuged to get the precipitate; the obtained solid was acidolysis and purified in 3mol / L hydrochloric acid solution, stirred and boiled for 2h; The turbid liquid was centrifuged and washed with deionized water for 5 times; the obtained product was dialyzed in a dialysis bag until the pH of the dialysate was 7; the product was ultrasonically dispersed for 3 hours, and then freeze-dried to obtain chitin whiskers (CHN whiskers) .

Embodiment 2

[0049] Embodiment 2: the preparation of chitin whisker

[0050] Weigh 30g of chitin powder, put it in 2mol / L potassium hydroxide solution, stir and boil for 10h, then stir at room temperature for 36h, filter and rinse the sample; the obtained precipitate is reacted in 80°C bleaching solution for 6h, and the bleaching solution is replaced every 2h Suction filtration, the sample was washed three times, and the gained sample was left standing in 2mol / L potassium hydroxide solution for 48h, then centrifuged to get the precipitate; the gained solid was acidolysis and purified in 2mol / L hydrochloric acid solution, stirred and boiled for 5h; The turbid liquid was centrifuged and washed with deionized water for 5 times; the obtained product was dialyzed in a dialysis bag until the pH of the dialysate was 7; the product was ultrasonically dispersed for 3 hours, and then freeze-dried to obtain chitin whiskers (CHN whiskers) .

Embodiment 3

[0051] Embodiment 3: the preparation of chitin whisker modified by polydopamine

[0052] Step (1): 100 mL of Tris (Tris) buffer solution with a pH of 8.5 is configured, and dopamine powder is added to obtain a dopamine solution concentration of 2 g / L, and then 5 g of CHN whiskers (product of Example 1) are added to dopamine at room temperature The solution was reacted for 6h under magnetic stirring.

[0053] Step (2): Centrifuge the product after the reaction in the above step (1) at a speed of 3000rpm in a centrifuge, remove the supernatant, take the lower layer of solid product, then add ethanol solution, ultrasonic 30min, and centrifuge to wash the solid The product was collected 5 times to remove the polydopamine homopolymer particles deposited on the surface of the solid product; finally, the solid product was collected by high-speed centrifugation at 4000 rpm in a centrifuge and dried in vacuum to obtain polydopamine-modified CHN whiskers (D-CHN whiskers) .

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Abstract

The invention belongs to the field of composite materials and discloses a chitin whisker / magnesium oxide whisker / biodegradable polyester composite material as well as a preparation method and an application thereof. The composite material comprises the following components in percentage by weight: 0.1-20% of chitin whisker, 0.1%-20% of magnesium oxide whisker and 60-99.8% of biodegradable polyester, wherein the chitin whisker is a natural high polymer polysaccharide whisker, the magnesium oxide whisker is an inorganic whisker, and biodegradable polyester is a class of synthetic high polymers. The ternary composite material is skillfully integrated with the advantages of a natural high polymer material, a synthetic high polymer material and an inorganic material; by adjusting the mass ratio of the chitin whisker to the magnesium oxide whisker, the reinforcing and toughening effects which are superior to the reinforcing and toughening effects of single chitin whisker or magnesium oxide whisker to a biodegradable polyester matrix can be obtained; and furthermore, a poly-dopamine layer modified on the surface of the whisker has excellent biocompatibility and osteogenic activity and can endow the composite material with relatively ideal bone tissue healing promoting capacity.

Description

technical field [0001] The invention belongs to the field of composite materials, and in particular relates to a chitin whisker / magnesia whisker / biodegradable polyester ternary composite material and its preparation and application. Background technique [0002] Among many human diseases, bone trauma or defect has become a worldwide frequently-occurring and common disease, and the market demand for bone tissue repair materials is huge. The bone tissue repair materials currently used clinically include non-degradable materials and degradable materials. Among them, non-degradable materials cannot be degraded and absorbed in the process of bone tissue repair, and require a second operation to remove them, and the use of metal-based orthopedic internal fixation materials will also cause Stress shielding affects the healing of bone tissue and damages the surrounding bone tissue. Therefore, degradable bone repair materials have attracted much attention in recent years. [0003] B...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L67/04C08L5/08C08K9/04C08K7/08C08B37/08C01F5/06C01F5/08
CPCC01F5/06C01F5/08C08B37/003C08L67/04C08L5/08C08K9/04C08K7/08
Inventor 罗丙红邹子平李文玲周长忍
Owner JINAN UNIVERSITY
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