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A functional monomer screening method for a molecularly imprinted membrane and a preparing method

A technology of molecularly imprinted membranes and functional monomers, applied in the field of membrane separation, to achieve the effects of easy industrial scale-up, strong separation selectivity, and good prediction results

Active Publication Date: 2016-03-30
CHINA PETROLEUM & CHEM CORP +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the extraction methods of puerarin mainly include solvent method, acid hydrolysis method, salting-out method, complex extraction method, macroporous adsorption resin method, etc., and molecularly imprinted membranes prepared based on molecular simulation technology have not been reported for the separation and purification of puerarin.

Method used

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  • A functional monomer screening method for a molecularly imprinted membrane and a preparing method
  • A functional monomer screening method for a molecularly imprinted membrane and a preparing method
  • A functional monomer screening method for a molecularly imprinted membrane and a preparing method

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preparation example Construction

[0072] On the basis of the above scheme, the present invention provides a method for preparing a molecularly imprinted membrane as described below, which specifically includes the following steps:

[0073] 1 basement membrane pretreatment:

[0074] Using the polymer microporous membrane as the base membrane, immerse the polymer microporous membrane in the ethanol or methanol solution of the photoinitiator, take it out after a period of time and let it dry naturally to obtain the polymer micropore covered with the photoinitiator on the membrane surface membrane;

[0075] 2 Preparation of molecularly imprinted membrane:

[0076] Using puerarin as a template molecule, the functional monomer with the largest interaction energy with puerarin was obtained through molecularly imprinted membrane functional monomer screening method,

[0077] Weigh the template molecules, functional monomers and cross-linking agents with a molar ratio of 1:(1-6):(10-20), and then mix them with the eth...

Embodiment 1

[0096] (1) Calculation, simulation and screening of functional monomers

[0097] 1.1 Calculate and get the simulation input file:

[0098] The molecular simulation system includes functional monomers and template molecule puerarin, and five monomers are selected as functional monomers to be screened, including acrylic hydroxyethyl methacrylate (HEMA), acrylic acid (ACA), glycidyl methacrylate Esters (GMA), and styrene-based styrene (STY), ethyl styrene (ESTY);

[0099] 1.2 Simulation:

[0100] The coordinates and topology files of functional monomers and puerarin were generated by PRODRG software as simulation input files, and the conditions of simulation calculation were as follows:

[0101] The simulation was performed in a water environment,

[0102] The GMX model is used for all molecules,

[0103] Using GROMACS3.2 for simulation calculation,

[0104] Using the NPT ensemble,

[0105] All systems are simulated and calculated in GROMACS87 force field;

[0106] First, ...

Embodiment 2

[0137] (1) This step is the same as in Example 1, and the functional monomer screened in Example 1 is used as the functional monomer in the molecular imprinting system.

[0138] (2) Preparation of molecularly imprinted membrane

[0139] 2.1 Basement membrane pretreatment:

[0140] With the polysulfone microporous membrane as the base membrane, the polysulfone microporous membrane was immersed in the ethanol solution of photoinitiator 127 with a concentration of 0.1mol / L, and it was taken out after 4 hours to dry naturally, and the surface of the membrane was covered with photoinitiator Agent polysulfone microporous membrane;

[0141] 2.2 Preparation of puerarin molecularly imprinted membrane:

[0142] The styrene screened out in step 1 is used as the functional monomer in the molecular imprinting system, and the puerarin is used as the template molecule in the molecular imprinting system;

[0143] Take 0.1mmol of puerarin, 0.6mmol of styrene, 1.0mmol of triallyl isocyanurat...

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Abstract

The invention relates to the technical field of membrane separation and particularly relates to a functional monomer screening method for a molecularly imprinted membrane and a preparing method. By adopting a molecular dynamics simulation technique, building a molecular model, calculating parameters, and researching the relation between interaction energy [delta]E between a selected model molecule and functional monomers and spatial conformation, a functional monomer used for synthesis of molecularly imprinted polymer is determined, thus directing designing and preparation of the molecularly imprinted membrane. The molecularly imprinted membrane is prepared by adopting a polymer micropore filtration membrane as a supporting membrane, adopting puerarin as the model molecule and initiating surface modification polymerization through ultraviolet light. The prepared molecularly imprinted membrane has an excellent puerarin molecule recognition performance, is advantaged by saved time and investment and high prediction capability, and is good in separation selectivity.

Description

technical field [0001] The invention relates to the technical field of membrane separation, in particular to a screening method and preparation method for functional monomers of molecularly imprinted membranes. In particular, it refers to the method of screening functional monomers based on computer molecular simulation technology and using the screened functional monomers to prepare molecularly imprinted membranes, which is a new method for preparing molecularly imprinted membranes. Background technique [0002] Molecular imprinting technology is a new method of polymer functionalization developed in the past ten years. The molecular imprinting process is mainly to polymerize functional monomers around the template molecules to form a main structure, and then extract the template molecules to obtain polymers. (molecular recognition polymers). In this way, identifiable cavities corresponding to the shape and function of the template molecule are formed in the polymer. When ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F226/06C08F212/08C08F2/48C08J9/26B01J20/26B01J20/30B01D71/28
Inventor 杨丽魏昕许树华
Owner CHINA PETROLEUM & CHEM CORP
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