Preparation method of calcium glycinate

A technology of calcium glycine and glycine, applied in the preparation of organic compounds, chemical instruments and methods, cyanide reaction preparation, etc., can solve the problem of large amounts of by-products of acid or lye, difficulty in large-scale industrial production, and easy coking of by-products, etc. problem, achieve the effect of shortening the reaction time, increasing the yield, and increasing the reaction yield

Inactive Publication Date: 2016-03-30
YANBIAN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing preparation methods of calcium glycinate mostly use water system synthesis method to prepare calcium glycinate or microwave solid phase method to synthesize calcium glycinate. The preparation method of water system synthesis method has long reaction time, high cost, and many by-products using a large amount of acid or lye. , waste liquid pollution, complex process and other shortcomings; the synthesis of calcium glycinate by microwave solid phase method has the problems of easy coking by-products and difficult realization of large-scale industrial production

Method used

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  • Preparation method of calcium glycinate
  • Preparation method of calcium glycinate
  • Preparation method of calcium glycinate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] A preparation method of calcium glycinate, comprising the following steps:

[0019] a, take by weighing 0.60g (8.0mmol) glycine and 0.44g (4.0mmol) calcium chloride anhydrous and join in the 100ml flask respectively, then add 20ml absolute ethanol;

[0020] b. The reaction system in step a above was reacted for 4 to 6 hours under the radiation of ultrasonic waves (RUC-2203DT—operating frequency: 42±1.5KHz; ultrasonic power: 100W), and a white precipitate—ultrafine powder was formed, which was left to stand;

[0021] c. The reaction product in step b above was washed several times with absolute ethanol, centrifuged, and vacuum-dried at 60° C. for 24 hours to obtain 0.71 g of white ultrafine powder with a yield of 94.3%. see figure 1 , 2 , 3.

Embodiment 2

[0023] Same as Example 1, but the anhydrous calcium chloride in the b step is changed into anhydrous calcium hydroxide to obtain white ultrafine powder 0.68g, and the productive rate is 90.3%.

Embodiment 3

[0025] Same as Example 1, but the anhydrous calcium chloride in the b step is changed to anhydrous calcium oxide to obtain white ultrafine powder 0.67g, and the productive rate is 89.0%.

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Abstract

The invention discloses a preparation method of calcium glycinate. Glycine and inorganic calcium are taken as raw materials and dispersed in absolute ethyl alcohol; a supersonic cleaner is used for applying ultrasonic reaction to a reaction system, and the reaction time ranges from 4 hours to 6 hours; a reaction product is washed for a plurality of times by an organic solvent, centrifugal filtration is performed, vacuum drying is performed at the temperature of 60 DEG C, and a target product with high purity is obtained. According to the preparation method, coordination reaction is efficiently performed under acid-and-alkali-free conditions, the reaction time is shortened, and complex synthesis and purification processes are avoided; mother liquor of calcium glycinate after can be recycled; the matching of the raw materials is scientific and reasonable, the yield and the purity are improved, and the calcium glycinate with high yield can be obtained.

Description

technical field [0001] The invention belongs to the technical field of fine chemicals, and specifically refers to a method for preparing calcium glycinate with high purity and high yield by using ultrasonic technology. Background technique [0002] Calcium is the most abundant and most important mineral element in the human body, accounting for about 2% of the adult body weight, and it plays a special role in life activities. With the renewal of people's health concepts and the rapid improvement of living standards, people pay more and more attention to calcium. Calcium supplements are commonly used calcium carbonate, active calcium, calcium gluconate, calcium lactate and so on. Calcium glycinate is an advanced new-generation product among calcium nutrition enhancers in today's society. Due to the unique physiological and biochemical functions of amino acids, it is easily absorbed and utilized by the human body after combining with calcium ions, and has dual functions of nu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C229/76C07C227/16
CPCC07C227/16C07C229/76
Inventor 张美善李籽萱朴英爱刘洋
Owner YANBIAN UNIV
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