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Prussian blue nano particle with high photo-thermal performance and of manganese-doped hollow structure and preparation method of prussian blue nano particle

A Prussian blue, hollow structure technology, applied in the field of nanomaterial preparation and biomedicine, can solve the problems of complex synthesis process and high cost, and achieve the effects of simple preparation process, uniform particle size, and high photothermal stability

Active Publication Date: 2016-03-23
HARBIN INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The purpose of the present invention is to provide a high photothermal performance in order to solve the problem that the existing manganese-doped Prussian blue (Mn-HPB) nano-particle photothermal performance and biological safety need to be improved, and the synthesis process is complicated and the cost is high. Manganese-doped hollow structure Prussian blue nanoparticles and preparation method thereof

Method used

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  • Prussian blue nano particle with high photo-thermal performance and of manganese-doped hollow structure and preparation method of prussian blue nano particle

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specific Embodiment approach 1

[0030] Specific Embodiment 1: This embodiment has manganese-doped hollow structure Prussian blue nanoparticles with high photothermal performance, which is a nano-cube structure with a diameter of 50-300 nm and a manganese-doped hollow structure Prussian blue nanoparticle with high photothermal performance. particle.

specific Embodiment approach 2

[0031] Specific embodiment two: the preparation method of manganese-doped hollow structure Prussian blue nanoparticles with high photothermal performance in this embodiment is carried out according to the following steps:

[0032] 1. Add 1-6g of surface protective agent and 100-150mg of potassium ferricyanide into 10-80mL acid solution with a concentration of 0.01-1M, then add manganese salt, mix well and put it into the polytetrafluoroethylene In the reaction kettle, heat to 50-150°C and react for 10-30 hours;

[0033] 2. After the reaction is finished, cool to room temperature, and successively wash with deionized water and absolute ethanol for 3 to 5 times to obtain a manganese-doped solid Prussian blue nanocubic sample, which is vacuum-dried for later use;

[0034] 3. Mix 5-40mL of acid solution with a concentration of 0.1-1M, 50-200mg of surface protection agent and 2-20mg of manganese-doped solid Prussian blue nano-cubic sample, ultrasonically disperse it evenly, and tra...

specific Embodiment approach 3

[0036] Embodiment 3: This embodiment is different from Embodiment 2 in that in step 1, 3 g of surface protection agent and 130 mg of potassium ferricyanide are added to 40 mL of acid solution with a concentration of 0.05 M, and then manganese salt is added. Others are the same as in the second embodiment.

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Abstract

The invention provides a prussian blue nano particle with high photo-thermal performance and of a manganese-doped hollow structure and a preparation method of the prussian blue nano particle, belongs to the field of nanometer material preparation and biomedicine and aims to solve the problems that existing the photo-thermal performance and biosecurity of an existing manganese-doped prussian blue nano particle are in need of improvement, the synthesis process is complex, and the cost is high. The preparation method includes the steps that surface protectant and potassium ferricyanide are added to an acid solution, manganese salt is added, and a heating reaction is conducted; 2, vacuum drying is conducted after washing is conducted; 3, the acid solution, the surface protectant and a manganese-doped solid prussian blue nano cubic sample are mixed, and the heating reaction is conducted after dispersing is conducted; washing is conducted, a blue porous Mn-HPB nano cubic material is obtained, and vacuum drying is completed. The prussian blue nano particle with high photo-thermal performance and of the manganese-doped hollow structure is simple in preparation process and high in controllability, the obtained nano material is uniform in particle diameter and good in dispersing property, and long-term and stable existence is achieved; excellent biosecurity is achieved; a higher photo-thermal effect and photo-thermal conversion efficiency are achieved, and the prussian blue nano particle and the preparation method are used for photo-thermal treatment of tumors.

Description

technical field [0001] The invention belongs to the fields of nanomaterial preparation and biomedicine, and in particular relates to a manganese-doped hollow Prussian blue light heat conversion material and a preparation method thereof. Background technique [0002] In recent years, due to environmental pollution and fast-paced life, cancer has become the second deadliest disease that threatens human life and health. Because of its strong metastases and invasiveness, its incidence rate keeps increasing year by year. Although many therapeutic techniques have been developed to treat cancer, the survival rate of cancer patients is still very low. At present, traditional cancer treatment methods such as surgery, chemotherapy, and radiotherapy have very limited therapeutic effects and severe side effects; for example, surgery is very difficult to eradicate cancer, and it is easy to relapse and cause serious interventional damage to the body; chemotherapy And radiation therapy is...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K47/04A61P35/00
CPCA61K41/0057A61K47/02
Inventor 于淼姜婷婷孙晔李正林唐巍杜宝盛
Owner HARBIN INST OF TECH
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