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A kind of preparation method of composite micro-nano fiber film for biological dressing

A technology of micro-nano fibers and biological dressings, which is applied in fiber processing, spinning solution preparation, medical science, etc., can solve the problems of electrospinning difficulties, fast degradation speed, and cytotoxicity, so as to avoid secondary biological toxicity and reduce Toxicity and cost, effectiveness of antimicrobial wound healing

Inactive Publication Date: 2017-09-29
ZHEJIANG TEXTILE GARMENT TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are two main problems in the preparation of collagen and chitosan electrospinning: one is that the electrospinning of collagen and chitosan is relatively difficult, and the spinning solvent usually uses hexafluoroisopropanol, hexafluoropropylene, trifluoroacetic acid, etc. Highly polar solvent, high cost, high toxicity
Another problem is that both collagen and chitosan electrospun fibers have disadvantages such as poor water resistance, low mechanical strength, fast degradation speed, and easy shrinkage and deformation. Its mechanical and physical properties
Glutaraldehyde is still the most widely used cross-linking agent at present. According to a large number of literature reports, glutaraldehyde has certain cytotoxicity and may cause the risk of tissue calcification, and collagen electrospun fibers are cross-linked by glutaraldehyde water vapor. The fibers will swell and shrink to a certain extent, and the adhesion between fibers is more serious.

Method used

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  • A kind of preparation method of composite micro-nano fiber film for biological dressing
  • A kind of preparation method of composite micro-nano fiber film for biological dressing
  • A kind of preparation method of composite micro-nano fiber film for biological dressing

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Weigh 0.21g of spongy type I collagen and 0.09g of polyethylene oxide powder (commercially available) and dissolve in 10mL of a mixed solution of hexafluoroisopropanol and acetic acid with a volume ratio of 5:5, and place it on a magnetic stirrer at room temperature to stir completely. Prepare a collagen / polyethylene oxide blend solution with a mass concentration of 3g / mL; weigh 0.27g of chitosan powder and 0.03g of polyethylene oxide powder and dissolve them together in 10mL of 90% acetic acid aqueous solution, and place at room temperature Stir on a magnetic stirrer to make it transparent, and prepare a chitosan / polyoxyethylene blend solution with a mass concentration of 3g / mL.

[0036] Mix the collagen / polyoxyethylene blended solution with a mass concentration of 3g / mL and the chitosan / polyoxyethylene blended solution with a mass concentration of 3g / mL at a mass ratio of 5:5, and add The cross-linking agent genipin accounting for 1% of the total mass of the mixed sol...

Embodiment 2

[0039] Weigh 0.21g of spongy type I collagen and 0.09g of polyethylene oxide powder and dissolve in 10mL of hexafluoroisopropanol and acetic acid with a volume ratio of 5:5 in a mixed solution, place it on a magnetic stirrer at room temperature and stir completely, and prepare a mass concentration of 3g / mL collagen / polyoxyethylene blend solution; weigh 0.27g chitosan powder and 0.03g polyoxyethylene powder and dissolve them in 10mL acetic acid aqueous solution with a volume fraction of 90%, and stir on a magnetic stirrer at room temperature Transparent, prepare a chitosan / polyoxyethylene blend solution with a mass concentration of 3g / mL.

[0040] Mix the collagen / polyoxyethylene blended solution with a mass concentration of 3g / mL and the chitosan / polyoxyethylene blended solution with a mass concentration of 3g / mL in a mass ratio of 6:4, and add The cross-linking agent genipin accounting for 2% of the total mass of the mixed solution was placed on a magnetic stirrer and stirred...

Embodiment 3

[0043] Weigh 0.32g of spongy type I collagen and 0.08g of polyethylene oxide powder and dissolve in 10mL of hexafluoroisopropanol and acetic acid with a volume ratio of 5:5 in a mixed solution, place it on a magnetic stirrer at room temperature and stir completely, and prepare a mass concentration of 4g / mL collagen / polyethylene oxide blend solution; weigh 0.36g chitosan powder and 0.04g polyoxyethylene powder to dissolve together with 10mL acetic acid aqueous solution with a volume fraction of 90%, and stir on a magnetic stirrer at room temperature Transparent, prepare a chitosan / polyoxyethylene blend solution with a mass concentration of 4g / mL.

[0044] Mix the collagen / polyethylene oxide blend solution with a mass concentration of 4g / mL and the chitosan / polyoxyethylene blend solution with a mass concentration of 4g / mL in a mass ratio of 7:3, and add The cross-linking agent genipin accounting for 2% of the total mass of the mixed solution was placed on a magnetic stirrer and ...

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Abstract

The invention discloses a method for preparing a biological dressing composite micro-nano fiber membrane. The method can solve the main problems in electrostatic spinning of collagen and chitosan. According to the method, a mixed solution of hexafluoroisopropanol and acetic acid, and an acetic acid water solution serve as a spinning solvent of a high molecular weight I-type collagen and a spinning solvent of the chitosan respectively, and then the toxicity and the cost of the solvent are reduced; a cross-linking agent genipin with excellent biocompatibility is directly added into a spinning solution to allow electrostatic spinning and chemical crosslinking to effectively combine together, so that the secondary biological toxicity due to the conventional crosslinking manner can be avoided; and the prepared collagen / chitosan / polyoxyethylene composite micro-nano fiber membrane is excellent in fiber morphology and biocompatibility, can serve as a biological dressing material, and has the functions of hemostasis, antibiosis, and wound healing.

Description

technical field [0001] The invention relates to the technical field of preparation of biological dressings, in particular to a preparation method of a composite micro-nano fiber membrane for biological dressings. Background technique [0002] Due to trauma, abrasions, skin ulceration and burns, etc., human skin may cause extensive damage to the skin. Skin damage is likely to cause bacterial infection, loss of body fluids and various complications. In the process of wound repair, dressing is an indispensable covering. Before the skin function is rebuilt and restored, it can temporarily cover the wound and act as a barrier temporarily to reduce the loss of body fluids and protect the human body from foreign bacteria and harmful substances. The violation of substances provides a powerful microenvironment for wound healing. [0003] Wound dressings can be roughly divided into traditional dressings, biological dressings, and synthetic dressings. Among them, the biological dress...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): D01D5/00D01D1/02D04H1/728A61L15/32A61L15/28A61L15/26A61L15/42
CPCA61L15/225A61L15/42D01D1/02D01D5/0038D04H1/728C08L89/00C08L5/08C08L71/02
Inventor 陈燕王仙
Owner ZHEJIANG TEXTILE GARMENT TECH
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