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Pharmaceutical preparation for preventing and treating alveolar echinococcus infection and application of pharmaceutical preparation

A pharmaceutical preparation and technology of alveolar hydatid, applied in the field of medicine, can solve problems such as treatment interruption, and achieve the effect of inhibiting alveolar hydatid infection

Inactive Publication Date: 2016-03-02
王丽
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are still failed cases reported, mainly due to the serious side effects of this class of drugs such as liver toxicity, etc. leading to interruption of treatment (IshizuH, UchinoJ, SatoN, et al. Effect of albendazole on recurrent and residual alveolare chinococcosis of liver after surgery [J]. 531.)

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] Embodiment 1: the preparation of Chinese medicine dry plaster powder

[0012] Weigh 1.6kg of Huoxiang, 1.2kg of Baiwei, 1.2kg of Artemisia annua, 1.2kg of Silkworm, 1.2kg of Polygala, 0.8kg of Wutongzi, 0.8kg of Shandougen, 0.3kg of Asarum and 0.5kg of Lianxu, add water to fry Boil twice, add 100L of purified water for the first time, decoct for 3h, add 90L of purified water for the second time, decoct for 2h, combine the decoctions, concentrate under reduced pressure at 0.08MPa, 70°C until the relative density is 1.15 at 70°C, Add 95% ethanol to make the alcohol content reach 75% (v / v), stir, let stand for 24 hours, filter, and concentrate the filtrate under reduced pressure at 0.08MPa and 65°C to obtain an extract with a relative density of 1.25. In a stainless steel pan, vacuum-dry (below 60°C) into a dry paste and pulverize.

Embodiment 2

[0013] Embodiment 2: the preparation of Chinese medicine sustained-release tablet

[0014] Weigh 0.5kg of Chinese medicine extract dry paste powder (prepared according to the formula process of Example 1), and pass through a 100-mesh sieve for subsequent use; weigh 0.2kg of HPMC-4M, and pass through an 80-mesh sieve for subsequent use; Mix the powder and HPMC-4M evenly, add an appropriate amount of 8% PVP absolute ethanol solution to granulate, dry at 60°C, sieve the dry granules with 16 meshes, add 6g of magnesium stearate to the dry granules, mix well, and make 9mm shallow concave punched tablets That is, about 1200 tablets were obtained.

Embodiment 3

[0015] Embodiment 3: the preparation of Chinese medicine sustained-release tablet

[0016] Weigh 0.5 kg of Chinese medicine extract dry cream powder (prepared according to the formula process of Example 1), and pass through a 100 mesh sieve for subsequent use; weigh 0.6 kg of ethyl cellulose, and pass through an 80 mesh sieve for subsequent use; Mix the cream powder and ethyl cellulose evenly, add an appropriate amount of 8% PVP absolute ethanol solution to granulate, dry at 60°C, sieve the dry granules with 16 meshes, add 8g of magnesium stearate to the dry granules, mix well, and make a 9mm shallow concave Punching tablets are obtained, and about 1400 tablets are obtained.

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PUM

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Abstract

The invention discloses a pharmaceutical preparation for preventing and treating alveolar echinococcus infection and application of the pharmaceutical preparation. The preparation consists of active ingredients and pharmaceutically acceptable adjuvant materials, wherein the active ingredients are prepared from the following traditional Chinese medicinal raw materials in parts by weight through a water extraction and alcohol precipitation method: 13-20 parts of herba pogostemonis, 9-16 parts of cynanchum atratum, 9-16 parts of artemisia apiacea, 9-16 parts of bombyx batryticatus, 9-16 parts of polygala tenuifolia, 6-10 parts of phoenix tree seeds, 6-10 parts of subprostrate sophora, 2-4 parts of asarum sieboldii and 3-6 parts of nelumbo nucifera gaertn. The pharmaceutical preparation disclosed by the invention can be used for obviously inhibiting the alveolar echinococcus infection, so that the pharmaceutical preparation is applicable to the clinical treatment of echinococciasis.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a pharmaceutical preparation for preventing and treating alveolar echinococcosis infection and its application. Background technique [0002] Alveolar echinococcosis is a potentially fatal zoonotic disease caused by infection with alveolar echinococcosis. At present, benzimidazoles such as mebendazole and albendazole are used clinically to treat alveolar echinococcosis, and this type of drug successfully inhibits the growth and recurrence of alveolar echinococcosis in some patients, prolongs their life and The postoperative quality of life was significantly improved. According to reports, the clinical success rate of benzimidazole drugs ranges from 55% to 90% (HemphillA, SpicherM, StadelmannB, et al. Innovative chemical therapeutic treatment options for alveolar and cysticechinococcosis [J]. Parasitology, 2007, 34 (12): 1657-1670.). However, there are still failed ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/69A61P33/10A61K35/64
CPCA61K36/532A61K9/0002A61K9/2054A61K36/185A61K36/268A61K36/27A61K36/282A61K36/489A61K36/62A61K36/69A61K2300/00
Inventor 王丽
Owner 王丽
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