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A method for continuously extracting active ingredients in seabuckthorn seeds

A technology of active ingredients and seabuckthorn seeds, which is applied in the field of extraction and separation and purification of natural products, can solve the problems of incomplete extraction and low extraction efficiency, achieve low extraction cost, short extraction time, and prevent waste of resources

Inactive Publication Date: 2019-04-19
NORTHWEST A & F UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0016] Aiming at the defects and deficiencies in the prior art, the object of the present invention is to provide a method for continuously extracting active ingredients in seabuckthorn seeds with simple process, low cost, short extraction time and high extraction efficiency, which overcomes the disadvantages of traditional extraction methods. Problems of incomplete extraction, low extraction efficiency, and destruction of thermally unstable components avoid waste of resources and are suitable for industrialized large-scale production

Method used

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  • A method for continuously extracting active ingredients in seabuckthorn seeds
  • A method for continuously extracting active ingredients in seabuckthorn seeds
  • A method for continuously extracting active ingredients in seabuckthorn seeds

Examples

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Effect test

Embodiment 1

[0062] Crush the clean and dry seabuckthorn seeds, put them in a sealable container, add n-hexane with a volume-to-weight ratio of 10 times, and extract ultrasonically for 5 minutes at a frequency of 30kHz, a power of 400W, and a temperature of 20°C. obtaining seabuckthorn seed oil extract; filtering the extract, recovering the solvent under reduced pressure (controlling the temperature not to exceed 30°C), and removing residual solvent to obtain seabuckthorn seed oil;

[0063] Add 50% ethanol-water solution with a volume-to-weight ratio of 10 times to the oil meal after extracting sea-buckthorn seed oil, and the power is 400W and the frequency is 30kH Z , ultrasonic extraction for 40 minutes at a temperature of 20° C. to obtain crude extracts of total flavonoids and total triterpene saponins from seabuckthorn seeds; filter the crude extracts under reduced pressure, concentrate under reduced pressure at 30° C., and place the concentrate in Vacuum and low-temperature drying at ...

Embodiment 2

[0067] Crush the clean and dry seabuckthorn seeds, put them in a sealable container, add petroleum ether with a volume-to-weight ratio of 20 times, and perform ultrasonic extraction for 30 minutes at a frequency of 80kHz, a power of 3000W, and a temperature of 30°C. Obtaining the seabuckthorn seed oil extract; filtering the extract, recovering the solvent under reduced pressure, and removing residual solvent to obtain the seabuckthorn seed oil; adding an 80% ethanol-water solution with a volume-weight ratio of 30 times to the oil meal after extracting the seabuckthorn seed oil, At a power of 3000W and a frequency of 80kH Z , Ultrasonic extraction at a temperature of 50°C for 10 minutes to obtain crude extracts of total flavonoids and total triterpene saponins from seabuckthorn seeds; filter the crude extracts under reduced pressure, concentrate under reduced pressure at 40°C, and concentrate under reduced pressure at 40°C Vacuum and low-temperature drying to obtain a crude ext...

Embodiment 3

[0071] The clean and dry seabuckthorn seeds are crushed and peeled, loaded in a sealable container, added with n-hexane with a volume-to-weight ratio of 30 times, and ultrasonically extracted at a frequency of 40kHz, a power of 800W, and a temperature of 30°C for 15 minutes. Obtain the seabuckthorn seed oil extract; filter the extract, recover the solvent under reduced pressure (control the temperature not to exceed 30°C), and remove the residual solvent to obtain the seabuckthorn seed oil; add a volume-to-weight ratio of 15 times 60% ethanol-water solution, at a power of 800W and a frequency of 40kH Z , ultrasonic extraction for 20 minutes at a temperature of 40°C to obtain crude extracts of total flavonoids and total triterpene saponins from seabuckthorn seeds; filter the crude extracts under reduced pressure, concentrate under reduced pressure at 30°C, and dilute the concentrate in Vacuum and low-temperature drying at 30°C to obtain a crude extract; add cold water with a vo...

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Abstract

The present invention discloses a method for continuous extracting of active ingredients in sea buckthorn seed, the method comprises the following steps: 1, using ultrasonic solvent extraction method for extracting sea buckthorn seed oil from the sea buckthorn seed to obtain the sea buckthorn seed oil and sea buckthorn seed oil meal; 2, using the ultrasonic solvent extraction method for extracting sea buckthorn seed total flavonoids and sea buckthorn seed total triterpenoid saponins from the sea buckthorn seed oil meal obtained by the step 1 to obtain a crude extract; and extracting and purifying the crude extract obtained by the step 2 to obtain the sea buckthorn seed total flavonoids and the sea buckthorn seed total triterpenoid saponins. The method is simple in process, low in cost, low in power consumption, short in extraction time and high in extraction yield and extraction efficiency, makes full use of the sea buckthorn seed and is suitable for large-scale industrial production.

Description

technical field [0001] The invention belongs to the technical field of extraction, separation and purification of natural products, and relates to a method for continuously extracting active ingredients in seabuckthorn seeds. Background technique [0002] Hippophaerhamnoides L. is a plant belonging to the genus Hippophaerhamnoides, which has the effects of invigorating the spleen and eliminating food, relieving cough and eliminating phlegm, promoting blood circulation and removing blood stasis (Gao Jinming et al., 1998; Gao Jinming and Zhang Anling, 1999). In addition to a large amount of oil, seabuckthorn seeds also contain active ingredients such as flavonoids, alkaloids, polysaccharides, proanthocyanidins, and saponins. It has been prepared as a prescription drug compound seabuckthorn seed oil suppository, which has achieved good curative effect in the treatment of cervicitis (Wang Shuangshuang et al., 2014). Modern pharmacological studies have shown that seabuckthorn se...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D311/62A61K36/185C11B1/10A61K131/00
Inventor 董娟娥高锦明刘景煜高宇琪
Owner NORTHWEST A & F UNIV
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