Benzofuran compound, preparation method and applications thereof
A technology of benzofuran and compound, applied in the field of benzofuran compound and its preparation, 2, can solve the problem of bacterial drug resistance and so on
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Embodiment 1
[0048] Synthesis of Triphenyl-(4-Methylbenzyl)phosphine Chloride
[0049] 4-Methylbenzyl chloride (50g, 356mmol) and triphenylphosphine (93.3g, 356mmol) were dissolved in 200mL of acetonitrile, heated to reflux for 6 hours, a white solid was formed, cooled to room temperature, filtered, and the residue was washed with 30mL After washing with ether three times, the residue was collected and vacuum-dried to obtain a white powder of triphenyl-(4-methylbenzyl)phosphine chloride (102 g, yield: 70%). 1HNMR (400MHz, DMSO-d 6 ), 8.00(d, J=7.04Hz, 1H), 7.89-7.97(m, J=8.22Hz, 2H), 7.65(d, J=7.83Hz, 1H), 7.41-7.49(m, J=8.22Hz , 2H), 7.36 (quin, J=6.85Hz, 2H), 4.56 (s, 2H).
Embodiment 2
[0051] Synthesis of E-2-(4-methylstyryl)phenol
[0052] Dissolve triphenyl-(4-methylbenzyl)phosphine chloride (100g, 248.2mmol) and 2-hydroxybenzaldehyde in 350mL acetonitrile, stir at room temperature and slowly add DBU (91.3mL, 595.7mmol), dropwise After the addition is complete, heat and stir under reflux for 12 hours to complete the reaction, cool to room temperature, concentrate the reaction solution, neutralize with dilute hydrochloric acid to neutrality, add 200 mL of water and extract 3 times with ethyl acetate, combine the organic phases, wash with 200 mL of saturated brine, anhydrous Dry over sodium sulfate, concentrate the organic layer, and separate and purify the white solid powder E-2-(4-methylstyryl)phenol (31.8 g, yield=61%) through silica gel column chromatography. 1 HNMR (400MHz, DMSO-d 6 )9.67(s, 1H), 7.52(d, J=7.43Hz, 1H), 7.40(d, J=7.83Hz, 2H), 7.32(d, J=16.82Hz, 1H), 7.09-7.17(m, 3H), 7.01-7.08(m, 1H), 6.83(d, J=7.83Hz, 1H), 6.77(t, J=7.43Hz, 1H), 2.27(...
Embodiment 3
[0054] Synthesis of 2-(4-methylphenyl)benzofuran
[0055] E-2-(4-methylstyryl)phenol and anhydrous K 2 CO 3 (21.2g, 154.2mmol) was dissolved in 150mL of tetrahydrofuran, and after stirring at room temperature for 1 hour, elemental iodine powder (39.4g, 154.2mmol) was added in one go. The unreacted iodine was removed by a saturated aqueous solution of sodium sulfite, extracted three times with ethyl acetate, the organic phases were combined, washed with saturated brine, dried over anhydrous sodium sulfate, the organic layer was concentrated, separated and purified by silica gel chromatography to obtain a white powder compound 2- (4-Methylphenyl)benzofuran (5.03 g, yield=94%). 1H NMR (400MHz, DMSO-d6) 7.78(d, J=8.22Hz, 2H), 7.57(d, J=8.61Hz, 1H), 7.60(d, J=7.43Hz, 1H), 7.32(s, 1H) , 7.28 (d, J=8.22Hz, 2H), 7.24 (dd, J=1.17, 6.26Hz, 1H), 7.19-7.22 (m, 1H), 2.32 (s, 3H).
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