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Oral antiseptic composition for treating oral mucositis

A technology of oral mucositis and composition, which is applied in the field of pharmaceutical composition and can solve problems such as discomfort

Active Publication Date: 2016-02-03
INGALFARMA SPA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Analgesics, such as lidocaine-based mouthwashes, are effective for pain for a short time, but over time, discomfort returns

Method used

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  • Oral antiseptic composition for treating oral mucositis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0071] Example 1: Preparation of an aqueous solution for mouthwash.

[0072]

[0073] The composition was prepared as follows:

[0074] 1. Add 800ml of demineralized water to a beaker.

[0075] 2. Subsequently, the components sucralose, camphor, hydrogen peroxide, p-chlorophenol, glycerin, eugenol, chamomile extract, xylitol, blue dye and mint flavoring were added in the above amounts.

[0076] 3. Then, add deionized water to bring the total volume to 950 mL.

[0077] 4. The pH is then adjusted to 7.00 using 0.1 N HCl or 0.1 N NaOH, or a suitable buffer such as benzoate / benzoic acid, and the mixture is weighed to 1000 g with demineralized water.

Embodiment 2

[0078] Example 2: Use of the composition for the treatment of oral mucositis in patients undergoing chemotherapy

[0079] A 40-year-old woman diagnosed with non-Hodgkin's lymphoma was treated with a combination of high-dose methotrexate and melphalan during the second cycle of chemotherapy. During the clinical evaluation, the status of oral mucositis was diagnosed as grade 2 according to the WHO grade (Table 1). Mouth rinse application of the composition of Example 1 (III), 10 ml, 5 times a day for 2 minutes is indicated.

[0080] The patient was observed on the third day, who showed complete resolution of the lesion and the absence of inflammatory features or pain, and his initial mucositis was reclassified as grade 0 according to the WHO scale (Table 1).

[0081] This treatment was continued throughout the cycle and no new oral lesions were shown.

[0082] In the next cycle of chemotherapy, doxorubicin, vincristine, and cyclophosphamide were administered, followed by the m...

Embodiment 3

[0085] Example 3: Use of the composition for the treatment of oral mucositis in patients concomitant with chemo-radiation therapy

[0086] A male patient, diagnosed with tonsil cancer, was prescribed a combination of radiotherapy and chemotherapy (cisplatin).

[0087]On the fourth day of treatment, the patient developed grade 2 oral mucositis according to the WHO scale (Table 1). Treatment with the composition indicated in Example 1 (III), 10 ml, 2 minutes, 5 times a day. Examination of his oral condition on the fourth day showed complete resolution of inflammation and reduction of pain, and the mucositis was reclassified as grade 0 according to the WHO scale (Table 1).

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PUM

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Abstract

The invention relates to a pharmaceutical antiseptic composition used to treat painful lesions of the oral mucous and ulcerative and inflammatory lesions of different origins. The invention also relates to the treatment and / or prevention of oral mucositis and stomatitis.

Description

technical field [0001] The present invention relates to pharmaceutical compositions, uses of such compositions and methods thereof for the treatment of painful lesions of the oral mucosa, ulcerative lesions such as aphthous ulcers etc., inflammatory lesions of different origins, and, in particular, for the treatment of Treatment and / or prevention of oral mucositis in anticancer therapy. In particular, the present invention provides the use of an oral pharmaceutical composition for the treatment and / or prevention of oral mucositis and stomatitis in anticancer therapy. In addition, the present invention provides a method for the treatment of oral mucositis and stomatitis associated with anticancer therapy. Background of the invention [0002] Aphthous stomatitis is an oral disorder that involves the formation of one or more sores that last for several weeks and leave scars after healing. These types of ulcers may reappear years later, continually returning with new lesions, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/045A61K31/05A61K31/125A61K31/155A61K31/325A61K31/327A61K33/40A61K36/00A61Q11/00A61P31/02A61K33/243
CPCA61K31/045A61K31/125A61K33/40A61K45/06A61K31/055A61K31/085A61K31/17A61K31/175A61K31/198A61K31/351A61K31/4425A61K31/475A61K31/513A61K31/519A61K31/675A61K31/704A61K31/7048A61K31/7068A61K31/7076A61K47/10A61K9/006A61K47/26A61K36/28A61K31/05A61P1/02A61P31/02A61K33/243A61K2300/00A61K33/24A61K31/155A61K31/325A61K31/327A61K36/00
Inventor 托马斯·贝尔纳多·加尔万冈萨雷斯
Owner INGALFARMA SPA
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