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Oxidized graphene doped nano-fibers, as well as preparation method and application thereof

A nanofiber and graphene technology, applied in fiber processing, fiber chemical characteristics, rayon manufacturing, etc., can solve the problems of patients' pain, reduce manufacturing costs, promote stem cell differentiation, and achieve good biocompatibility.

Active Publication Date: 2016-02-03
SUZHOU INST OF NANO TECH & NANO BIONICS CHINESE ACEDEMY OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, both methods will bring great pain and sequelae to patients

Method used

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  • Oxidized graphene doped nano-fibers, as well as preparation method and application thereof
  • Oxidized graphene doped nano-fibers, as well as preparation method and application thereof
  • Oxidized graphene doped nano-fibers, as well as preparation method and application thereof

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preparation example Construction

[0047] Another aspect of the present invention provides a method for preparing the aforementioned scaffold material, which may include: taking a spinning solution containing poly(lactic-co-glycolic acid) and graphene oxide and subjecting it to an electrospinning process to obtain the nanofiber scaffold material.

[0048] In a preferred solution, the spinning solution contains polylactic acid glycolic acid at a concentration of 10wt% to 20wt%, graphene oxide with a content of 0.1wt% to 5wt% of the polylactic acid glycolic acid content, and volatile and A solvent with good solvency for polylactic-glycolic acid.

[0049] Further, the solvent used in the spinning solution can be selected and is not limited to tetrahydrofuran and / or dimethylformamide, and through a large number of experimental verifications, the inventors of the present case found that when the solvent of tetrahydrofuran and dimethylformamide is selected When mixed solvents are used as solvents, pure PLGA nanofiber...

Embodiment 1

[0058] 1. Preparation of PLGA electrospinning solution doped with graphene oxide

[0059] Prepare 15% and 18% PLGA electrospinning solutions, weigh 1.8 grams of PLGA powder with an electronic balance and dissolve them in 12 milliliters and 10 milliliters of tetrahydrofuran / dimethylformamide with a volume ratio of 3:1 in a mixed solvent to prepare Concentration is 15wt% and 18wt% PLGA spinning solution, 4 ℃ stands overnight, obtains uniform PLGA solution, standby;

[0060] Weigh 18 mg of graphene oxide powder with an electronic balance and add it to the prepared PLGA spinning solution with a concentration of 15wt% and 18wt%, and stir magnetically for more than 24 hours to make graphene oxide uniformly dispersed in the PLGA spinning solution. Sonicate for 30 minutes before use to remove air bubbles.

[0061] 2. Preparation of doped graphene oxide electrospun PLGA nanofibers

[0062] Four freshly prepared PLGA electrospinning solutions doped with graphene oxide (15wt% and 1...

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Abstract

The invention discloses oxidized graphene doped nano-fibers, as well as a preparation method and application thereof. The nano-fibers are continuous nano-fibers with smooth surfaces and mainly formed by oxidized graphene and poly(lactic-co-glycolic acid) using an electrostatic spinning method. The nano-fibers provided by the invention can be used to form a porous three-dimensional structured nano-fiber scaffold material for tissue engineering. The scaffold material for tissue engineering simulates cell natural extracellular matrix, wherein the diameter of the nano-fiber ranges from a dozen nanometers to several micrometers, and the nano-fiber is similar with the collagen fiber in the extracellular matrix; the scaffold material provided by the invention has a porous topology structure with a high specific surface area and simulating the extracellular matrix, can provide better growth environment for the cells, can remarkably promote the adhesion, proliferation and differentiation of the stem cells; at the same time, the preparation technology of the nano-fibers is simple without using complicated equipment; mass production can be achieved, and the manufacturing cost is low.

Description

technical field [0001] The invention relates to a tissue engineering material, in particular to a doped graphene oxide nanofiber, its preparation method and application, and belongs to the field of living tissue repair, such as the field of regenerative medicine for bone damage repair. Background technique [0002] Bone injury is one of the common and frequent types of injury in clinic. With the continuous advancement of science and technology, bone injury repair materials have been continuously improved and improved. Up to now, two main methods have been adopted for the repair of bone injuries: 1. Perform surgery to fix the damaged part and then heal itself; 2. Use substitutes to replace the damaged part. However, both methods will bring great pain and sequelae to patients. Therefore, the development of a more excellent method has become an urgent problem to be solved in the field of clinical medicine. [0003] The purpose of tissue engineering is to seek a scientific met...

Claims

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Application Information

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IPC IPC(8): D01F6/92D01F1/10D01D5/00A61L27/18A61L27/02A61L27/56
Inventor 张智军罗宇沈贺
Owner SUZHOU INST OF NANO TECH & NANO BIONICS CHINESE ACEDEMY OF SCI
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