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Anti-infection calcium phosphate composite bone cement material and preparation method thereof

A calcium phosphate bone cement and calcium phosphate technology, applied in surgical adhesives, applications, medical science, etc., can solve problems such as narrow application range, low reliability, and high vulnerability, and achieve long effective action time and antibacterial spectrum The effect of wide and strong material adaptability

Active Publication Date: 2016-02-03
GUANGDONG INST OF MICROBIOLOGY GUANGDONG DETECTION CENT OF MICROBIOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to provide a coating-type medical anti-infection biological material with reliable anti-infection performance, long effective action time, antibacterial Anti-infective calcium phosphate composite bone cement material with broad spectrum and strong material adaptability and preparation method thereof

Method used

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] An anti-infection calcium phosphate composite bone cement material is prepared through the following steps:

[0029] (1) Weigh gamma-polyglutamic acid and phosphorylcholine, the mass ratio of gamma-polyglutamic acid and phosphorylcholine is 1:1, place gamma-polyglutamic acid and phosphorylcholine in a sufficient amount without In water ethanol, keep stirring for 12h (the beaker is sealed with plastic wrap to prevent ethanol volatilization, so that the reaction is always carried out under the environment of absolute ethanol), and then the mixed solution is mixed with 4 × 10 3 Centrifuge at rpm for 2 min, discard the supernatant, evacuate, evaporate, and freeze-dry to obtain a white powder of γ-polyglutamic acid-phosphocholine.

[0030] (2) ultrasonically dissolve the white powder of γ-polyglutamic acid-phosphocholine obtained in step (1) in anhydrous dimethyl sulfoxide to prepare 5.0 g / L of γ-polyglutamic acid-phosphorylcholine solution, sealed for later use. Configure 0...

Embodiment 2

[0037] An anti-infection calcium phosphate composite bone cement material is prepared through the following steps:

[0038] (1) Weigh gamma-polyglutamic acid and phosphorylcholine, the mass ratio of gamma-polyglutamic acid and phosphorylcholine is 1:2, place gamma-polyglutamic acid and phosphorylcholine in absolute ethanol , kept stirring for 18 hours (the beaker was sealed with plastic wrap to prevent the volatilization of ethanol, so that the reaction was always carried out in an anhydrous ethanol environment), and then the mixed solution was mixed with 4 × 10 3 Centrifuge at rpm for 10 min, discard the supernatant, evacuate, evaporate, and freeze-dry to obtain a white powder of γ-polyglutamic acid-phosphocholine.

[0039] (2) ultrasonically dissolve the γ-polyglutamic acid-phosphorylcholine white powder obtained in step (1) in anhydrous dimethyl sulfoxide to prepare a 10 g / L γ-polyglutamic acid-phosphocholine solution , sealed for later use. Configure 1.0mmol / L nano-silve...

Embodiment 3

[0046] An anti-infection calcium phosphate bone composite cement material is prepared through the following steps:

[0047] (1) Weigh gamma-polyglutamic acid and phosphorylcholine, the mass ratio of gamma-polyglutamic acid and phosphorylcholine is 1:4, place gamma-polyglutamic acid and phosphorylcholine in absolute ethanol , kept stirring for 12 hours (the beaker was sealed with plastic wrap to prevent the volatilization of ethanol, so that the reaction was always carried out under the environment of absolute ethanol), and then the mixed solution was mixed with 4 × 10 3 Centrifuge at rpm for 15 minutes, discard the supernatant, evacuate, evaporate, and freeze-dry to obtain a white powder of γ-polyglutamic acid-phosphocholine.

[0048] (2) ultrasonically dissolve the white powder of gamma-polyglutamic acid-phosphocholine obtained in step (1) in anhydrous dimethyl sulfoxide to prepare a 50 g / L gamma-polyglutamic acid-phosphorylcholine solution , sealed for later use. Configure...

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Abstract

The invention discloses an anti-infection calcium phosphate composite bone cement material and a preparation method thereof. The preparation method comprises the following steps: enabling gamma-polyglutamic acid modified by phosphorylcholine to adsorb nano-silver, and carrying out graft copolymerization reaction between water-soluble polysaccharide and gamma-polyglutamic acid to prepare a nano-silver anti-infection agent with an anti-infection effect; and on the basis that the basic characteristics of calcium phosphate bone cement are not affected, compounding and blending the anti-infection agent and other assistants with medical calcium phosphate bone cement, and then preparing the calcium phosphate composite bone cement material with an anti-infection function by adopting a molding method. The method disclosed by the invention is simple in process, and the compressive strength of the prepared calcium phosphate composite bone cement material reaches 70MPa; the calcium phosphate composite bone cement material does not have obvious cytotoxicity and blood coagulation to osteoblasts and bone marrow stromal cells and does not have obvious sensitization, stimulation and genetic toxicity; and the calcium phosphate composite bone cement material has a wide antibacterial spectrum and has certain antibacterial effects on Gram-positive cocci and Gram-negative bacilli, and the antibacterial rate reaches 98%.

Description

technical field [0001] The invention belongs to the technical field of biological materials, and in particular relates to an anti-infection calcium phosphate composite bone cement material and a preparation method thereof. Background technique [0002] During the use of biological materials and their products, a series of problems such as incomplete compatibility with body tissues, infection, canceration, and calcification of biological tissue materials have been encountered to varying degrees. Among them, the incidence of biomaterial-related infection (BRI) has increased significantly with the increase in the application of biomaterials, and the prevention and treatment of biomaterial-related infection is an urgent clinical problem that needs to be solved. Many studies have shown that the implantation of biomaterials increases the pathways of bacterial invasion of the host, reduces the body's defense capabilities, and weakens the effect of preventing bacterial adhesion and ...

Claims

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Application Information

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IPC IPC(8): A61L27/54A61L27/42A61L27/20A61L27/18A61L27/12A61L24/04A61L24/02C08G69/48
Inventor 疏秀林施庆珊冯静阳运华谢小保黄小茉
Owner GUANGDONG INST OF MICROBIOLOGY GUANGDONG DETECTION CENT OF MICROBIOLOGY
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