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No-washing type hand disinfectant with moisturizing and bacterium preventing effects and preparation method thereof

A hand sanitizer, disposable technology, applied in antibacterial, antifungal, and skin care preparations, etc., can solve the problems of limited types of sterilization, dry and volatile hand skin, etc., and achieve good whitening. Antioxidative effect, broad-spectrum antibacterial effect, enhanced bactericidal effect

Inactive Publication Date: 2016-01-20
合肥天一生物技术研究所有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] The main bactericidal ingredients of hand sanitizers currently on the market are iodine, alcohols, triclosan (DP300), guanidines, quaternary ammonium salts and their compound preparations. These disinfectants exist in varying degrees It is easy to lead to drug resistance and allergic reactions, unstable product properties, susceptible to environmental influences, short validity period, volatile, limited sterilization types, skin irritation and other side effects, especially for long-term and large-scale use by medical staff. Cause dry, chapped hand skin, and even damage hand skin cells

Method used

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  • No-washing type hand disinfectant with moisturizing and bacterium preventing effects and preparation method thereof
  • No-washing type hand disinfectant with moisturizing and bacterium preventing effects and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] (1) First mix 1g of Daphne chamaejasme, 10g of Drunken Horse Grass, 1g of Pulsatilla chinensis, and 5g of Niuxinpuzi, then add 95% ethanol which accounts for 8 times its weight, seal and cold soak for 24 hours, filter, and use a rotary evaporator to Evaporate at 58°C until the crude drug concentration is 1g / ml at room temperature to obtain mixture A;

[0029] Then add 1g of thistle, 10g of white peony root, 1g of Angelica dahurica, 10g of white poria cocos, 1g of hosta flower, 5g of impatiens, 1g of rose, 5g of water hyacinth, 1g of snow lotus, 5g of hawthorn, 1g of tangerine peel, 1g of honeysuckle, 1g of propolis Mix evenly, then add purified water accounting for 10 times its total weight for decoction, then filter, and use a rotary evaporator to evaporate at 78°C until the crude drug concentration is 1g / ml at room temperature to obtain mixture B;

[0030] Finally, mixture A and mixture B are mixed to obtain a compound Chinese herbal medicine extract;

[0031] (2) Mi...

Embodiment 2

[0036] (1) First mix 10g Daphne chamaejasme, 10g Drunken Horse Grass, 10g Pulsatilla chinensis, and 1g Niuxinpuzi, then add 95% ethanol which accounts for 9 times its weight, seal and cold soak for 24 hours, filter, and use a rotary evaporator to Evaporate at 58°C until the crude drug concentration is 3g / ml at room temperature to obtain mixture A;

[0037]Then add 5g of thistle, 10g of white peony root, 10g of white peony, 1g of white poria cocos, 1g of hosta flower, 1g of impatiens, 1g of rose, 1g of water hyacinth, 1g of snow lotus, 1g of hawthorn, 5g of tangerine peel, 5g of honeysuckle, 5g of propolis Mix evenly, then add purified water accounting for 9 times its total weight for decoction, then filter, and use a rotary evaporator to evaporate at 78°C until the crude drug concentration is 3g / ml at room temperature to obtain mixture B;

[0038] Finally, mixture A and mixture B are mixed to obtain a compound Chinese herbal medicine extract;

[0039] (2) Mix 5ml of glycerin,...

Embodiment 3

[0044] (1) First mix 5g of Daphne chamaejasme, 5g of Drunken Horse Grass, 5g of Pulsatilla chinensis, and 1g of Pulsatilla chinensis, then add 95% ethanol which accounts for 10 times its weight, seal and cold soak for 24 hours, filter, and use a rotary evaporator to Evaporate at 58°C until the crude drug concentration is 2g / ml at room temperature to obtain mixture A;

[0045] Then add 2g of thistle, 4g of white peony, 6g of white peony, 10g of white poria cocos, 2g of hosta flower, 3g of impatiens, 2g of rose, 3g of water hyacinth, 4g of snow lotus, 1g of hawthorn, 5g of tangerine peel, 5g of honeysuckle, 2g of propolis Mix evenly, then add purified water accounting for 10 times its total weight for decoction, then filter, and use a rotary evaporator to evaporate at 78°C until the crude drug concentration is 2g / ml at room temperature to obtain mixture B;

[0046] Finally, mixture A and mixture B are mixed to obtain a compound Chinese herbal medicine extract;

[0047] (2) Mix ...

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Abstract

The invention provides a no-washing type hand disinfectant with the moisturizing and bacterium preventing effects. The no-washing hand disinfectant is prepared form 20-30 parts of composite Chinese medicine material extracts, 1-15 parts of natural moisturizing factors, 55-65 parts of ethyl alcohol, 0.2-4.0 parts of chlorhexidine digluconate, 1-5 parts of glycerinum, 1-5 parts of tween-8-, 0.2-2.5 parts of penetrating agents, 0.01-0.05 part of ethylenediamine tetraacetic acid disodium salt (EDTA-Na2), 0.02-0.1 part of essences and 0.01-0.05 part of food coloring, the pH value of the mixture is regulated to 6.00-8.00 by a pH regulating agent, and then the mixture is supplemented to 100 parts with purified water. According to the no-washing type hand disinfectant with the moisturizing and bacterium preventing effects and the preparation method thereof, the formula is reasonable, the property is stable, the good sterilizing effect is achieved, pathogenic entero becteria, pyogenic cocci, pathogenic yeasts and common nosocomia infection bacteria can be effectively killed, efficient moisturizing is achieved, and the side effects such as chapped hand skin due to the disinfectant is used for a long term in large quantities can be effectively overcome.

Description

technical field [0001] The invention relates to a disinfectant, in particular to a moisturizing and antibacterial disposable hand disinfectant and a preparation method thereof. Background technique [0002] The main bactericidal ingredients of hand sanitizers currently on the market are iodine, alcohols, triclosan (DP300), guanidines, quaternary ammonium salts and their compound preparations. These disinfectants exist in varying degrees It is easy to lead to drug resistance and allergic reactions, unstable product properties, susceptible to environmental influences, short validity period, volatile, limited sterilization types, skin irritation and other side effects, especially for long-term and large-scale use by medical staff. Causes dry, chapped hand skin, and even damages hand skin cells. Contents of the invention [0003] The invention provides a moisturizing and antibacterial disposable hand disinfectant with mildness, moisturizing and skin care, broad-spectrum a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/99A61K8/98A61K8/97A61K8/43A61K8/34A61K8/49A61K8/365A61Q19/10A61Q19/02A61Q19/00A61P31/04A61P31/10
CPCA61K8/99A61K8/34A61K8/365A61K8/43A61K8/4906A61K8/4913A61K8/97A61K8/988A61Q17/005A61Q19/00A61Q19/02A61Q19/10
Inventor 尹培培何流张艳徐寅生程航
Owner 合肥天一生物技术研究所有限责任公司
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