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A fingerprint assay method of Hedan preparation

The technology of fingerprint spectrum and determination method is applied in the field of fingerprint spectrum determination of Hedan preparations, which can solve the problem of no fingerprint spectrum of Hedan preparations, and achieve the effects of stable drug quality, accurate detection and high degree of separation.

Active Publication Date: 2017-02-01
NANCHANG JISHUN PHARMA CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, there is no report on the fingerprint research work of Hedan preparations

Method used

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  • A fingerprint assay method of Hedan preparation
  • A fingerprint assay method of Hedan preparation
  • A fingerprint assay method of Hedan preparation

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Experimental program
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Effect test

Embodiment 1

[0057] A fingerprint assay method for Hedan preparation, comprising the following steps:

[0058] 1. Instruments, reagents and medicines

[0059] 1. Instrument

[0060] Agilent1200 high performance liquid chromatography (quaternary pump, online degasser, autosampler, column thermostat, diode array detector), METTLERAE240 balance (Mettler-Toledo Instruments (Shanghai) Co., Ltd.), SG8200H Ultrasonic instrument (Shanghai Guante Ultrasonic Instrument Co., Ltd.), W2018 constant temperature water bath (Shanghai Shensheng Technology Co., Ltd.), SHB-3A circulating water multi-purpose vacuum pump (Shanghai Yarong Biochemical Instrument Factory);

[0061] 2. Reagents

[0062] Methanol and acetonitrile are chromatographic alcohols (U.S. Tedia Reagent Company), water is double distilled water, and other reagents are all domestically produced analytically pure;

[0063] 3. Drugs

[0064] Hedan tablets are provided by Nanchang Jishun Pharmaceutical Co., Ltd., production batch number S ...

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Abstract

The invention discloses a fingerprint spectrum measuring method for a hedan preparation. The method includes the steps that a standard control fingerprint spectrum is established, a fingerprint spectrum of a to-be-measured sample is measured, the standard control fingerprint spectrum and the fingerprint spectrum of the to-be-measured sample are compared, and whether the to-be-measured sample is qualified or not is identified. Detection is accurate, operation is easy and convenient, trichloromethane is selected as an extraction solvent, chromatographic conditions such as detection wavelength and gradient elution are optimized, effective ingredients of the hedan preparation are promoted to be completely extracted, the obtained fingerprint spectrum information amount is large, the resolution of a chromatogram is high, the trailing phenomenon of the chromatogram is effectively avoided, the quality of the hedan preparation can be monitored, and it is guaranteed that the quality of medicine is stable and uniform.

Description

technical field [0001] The invention relates to the technical field of fingerprints of traditional Chinese medicine preparations, in particular to a method for measuring fingerprints of Hedan preparations. Background technique [0002] Hedan Tablets and Hedan Capsules are traditional Chinese medicine compound preparations made from a variety of natural Chinese medicinal materials. By. Since the Hedan preparation was launched on the market, it has been well received by patients because of its good therapeutic effect, quick effect and low price. The main ingredients of Hedan preparation include lotus leaf, salvia miltiorrhiza, hawthorn, senna leaf and psoralen. Modern pharmacological research has proved that it contains a variety of biologically active substances. The existing quality standards for Hedan preparations only carry out quantitative detection of its main component, nuciferine. For Chinese patent medicines with complex components and unclear active ingredients, th...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/88G01N30/06
Inventor 何凯南曾英姿周万辉安少凯赵磊陈武
Owner NANCHANG JISHUN PHARMA CO LTD
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