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Method for improving sensitivity of surface plasmon resonance sensor

A sensor and sensitivity technology, applied in the field of measurement, can solve problems such as the influence of system sensitivity

Inactive Publication Date: 2015-12-30
SHENZHEN GRADUATE SCHOOL TSINGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
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Problems solved by technology

However, we found in the research that in addition to the film structure of SPR, the spectral response curve of the spectral SPR sensor will also affect the sensitivity of the actual system

Method used

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  • Method for improving sensitivity of surface plasmon resonance sensor
  • Method for improving sensitivity of surface plasmon resonance sensor
  • Method for improving sensitivity of surface plasmon resonance sensor

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Embodiment 1

[0039] Embodiments of the present invention provide a method for improving the sensitivity of an SPR sensor, comprising the steps of:

[0040] Step (1), providing a light source and a detector, and obtaining a first spectral response curve of the light source and detector, wherein, within the wavelength range of the first spectral response curve, the spectral response characteristic decreases monotonously with increasing wavelength.

[0041] The light source can be, for example, a tungsten-halogen lamp, a xenon lamp, or an LED. In this embodiment, a tungsten-halogen lamp (Daheng Optoelectronics GCI-060101M, 150W) is selected.

[0042] The detector is, for example, a silicon-based CCD, CMOS, or photodiode array. In this embodiment, a silicon-based CCD camera (QimaingQClick1394) is selected.

[0043] The SPR sensor described in this embodiment is a spectral SPR sensor.

[0044] Obtain the overall spectral response curve of the light source and the detector, and select the first s...

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Abstract

The invention relates to a method for improving the sensitivity of a surface plasmon resonance sensor based on a spectral response curve. The method comprises the steps that the first spectral response curve monotonically decreasing within a selected wavelength range is obtained; the incident angle of the SPR sensor is adjusted, so that within a preset refractometry range, the resonant wavelength of the SPR is within the wavelength range of the spectral response curve and is better at the end of the long wave; the position of the resonant wavelength of the SPR is judged directly through original spectral data of a system, and adopted as output data of the sensor, and therefore the sensitivity of the spectral type SPR sensor is improved.

Description

technical field [0001] The invention belongs to the field of measurement technology, in particular to a method for improving the sensitivity of an SPR (surface plasmon resonance) sensor, more specifically, to a method for improving the sensitivity of an SPR (surface plasmon resonance) sensor based on a spectral response curve method. Background technique [0002] The surface plasmon resonance (SPR) sensing method is a highly sensitive and label-free sensing method, which has been widely used in biology, chemistry, environment, clinical and other fields (ChemRev, 2008, 108:462–493 ). [0003] This method uses a special SPR excitation device (such as a layer of metal film coated on the inclined surface of a prism) to detect the relationship between the intensity, phase, wavelength and incident angle of reflected light, and can achieve a better than 10 -5 to 10 -7 (refractive index unit, RIU) resolution detects the change of the refractive index on the surface of the metal f...

Claims

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Application Information

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IPC IPC(8): G01N21/552G01N21/41
Inventor 刘乐陈振翎何永红郭继华
Owner SHENZHEN GRADUATE SCHOOL TSINGHUA UNIV
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