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High-sensitivity glucose sensor

A glucose sensor and glucose oxidase technology, applied in the field of high-sensitivity glucose sensors, can solve the problems of poor reproducibility, long response time, poor selectivity and stability, etc., and achieve short response time, high sensitivity, and binding force. strong effect

Inactive Publication Date: 2015-12-23
HEBEI NORTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing glucose sensor has the defects of long response time, poor reproducibility, poor selectivity and stability, and cannot meet the needs of current social development.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] A high-sensitivity glucose sensor, comprising a substrate, an electrode system arranged on the substrate, and a reagent layer arranged on the electrode system; the electrode system includes a working electrode with a lead part and a counter electrode with a lead part; the substrate A detection part is arranged on the top of one side, and a reagent layer is arranged on the electrodes of the detection part;

[0017] Wherein, the material of the substrate is polystyrene; the working electrode is a glassy carbon electrode; the reagent layer is prepared according to the following process:

[0018] S1. Add 120 parts of Tris reagent in 100 parts by weight of a graphene oxide solution with a mass fraction of 50% and stir evenly. After adjusting the pH value to be alkaline, add 50 parts of dopamine and stir for 10 hours. After the reaction, use 10000r / m Centrifuge at a speed of min for 10 minutes, wash with deionized water, dry in vacuum, and then heat-treat under the protection...

Embodiment 2

[0022] A high-sensitivity glucose sensor, comprising a substrate, an electrode system arranged on the substrate, and a reagent layer arranged on the electrode system; the electrode system includes a working electrode with a lead part and a counter electrode with a lead part; the substrate A detection part is arranged on the top of one side, and a reagent layer is arranged on the electrodes of the detection part;

[0023] Wherein, the material of the substrate is polyethylene; the working electrode is a gold electrode; the reagent layer is prepared according to the following process:

[0024] S1. Add 140 parts of Tris reagent in 170 parts by weight of a graphene oxide solution with a mass fraction of 43% and stir evenly. After adjusting the pH value to be alkaline, add 35 parts of dopamine and stir for 18 hours. After the reaction, use 9000r / m Centrifuge at a speed of 14 min, wash with deionized water, dry in vacuum, and then heat-treat under the protection of argon to obtain N...

Embodiment 3

[0028] A high-sensitivity glucose sensor, comprising a substrate, an electrode system arranged on the substrate, and a reagent layer arranged on the electrode system; the electrode system includes a working electrode with a lead part and a counter electrode with a lead part; the substrate A detection part is arranged on the top of one side, and a reagent layer is arranged on the electrodes of the detection part;

[0029] Wherein, the material of the substrate is polypropylene; the working electrode is a platinum electrode; the reagent layer is prepared according to the following process:

[0030] S1. Add 150 parts of Tris reagent in 200 parts by weight of a graphene oxide solution with a mass fraction of 40% and stir evenly. After adjusting the pH value to be alkaline, add 20 parts of dopamine and stir for 20 hours. After the reaction, use 8000r / m Centrifuge at a speed of min for 15 minutes, wash with deionized water, dry in vacuum, and then heat-treat under the protection of ...

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Abstract

The invention discloses a high-sensitivity glucose sensor which comprises a substrate, an electrode system and a reagent layer. The electrode system is configured on the substrate, and the reagent layer is configured on the electrode system. The electrode system comprises a working electrode and a counter electrode, wherein the working electrode is provided with a lead portion, and the counter electrode is provided with a lead portion. A detection portion is arranged on the upper face of the top of one side of the substrate. The reagent layer is configured on the electrode of the detection portion. The reagent layer comprises N-doped graphene, a carboxylation carbon nano tube and glucose oxidase. The high-sensitivity glucose sensor is good in stability, good in glucose detection selectivity, short in response time and high in sensitivity.

Description

technical field [0001] The invention relates to the technical field of glucose sensors, in particular to a high-sensitivity glucose sensor. Background technique [0002] Diabetes is the third most dangerous disease after cancer and cardiovascular disease, and it is a frequently-occurring and common disease worldwide. Therefore, the accurate and rapid determination of glucose content in human blood is of great significance for the early diagnosis and treatment of diabetes. Glucose biosensor is a simple and quick method to detect the concentration of glucose in human blood, and it has attracted more and more attention from researchers. However, the existing glucose sensors have the defects of long response time, poor reproducibility, poor selectivity and stability, and cannot meet the needs of current social development. Contents of the invention [0003] The object of the present invention is to solve the shortcomings in the prior art, and propose a high-sensitivity gluco...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/26
Inventor 张晓田野彭伟
Owner HEBEI NORTH UNIV
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