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Preparation method and application of non-decocted fructus psoraleae preparation

A technology of psoralen and preparations, which is applied in the field of preparation of psoraleae-free decoction preparations, can solve the problems of fixed curative effect, limited application range, and inability to mix and match the finished compound decoction, and achieve synergistic effect of process steps and reduce energy consumption. The effect of reducing consumption and reducing damage

Inactive Publication Date: 2015-12-23
HENAN XINGZHI PATENT SERVICE CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although where conditions permit, some hospitals and outpatient clinics have finished compound decoction products in reserve, which can be consumed only by heating. However, the curative effect of each pair of compound decoction finished products is fixed and cannot be mixed according to various diseases. Flexibility Poor, when storing the finished compound decoction at the same time, there are problems such as occupying space and wasting energy, and the efficacy of the finished compound decoction will gradually decrease during the storage process
Furthermore, the preparation of psoraleae extract and other Chinese herbal medicines into a compound preparation, due to the fixed formula and definite curative effect, its application range is limited to a certain extent

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0026] The invention provides a preparation method of psoraleae-free decoction preparation, which is carried out according to the following steps:

[0027] 1) Wash the psoraleae medicinal material to remove impurities, and dry it below 60°C;

[0028] 2) Take the dried psoralen medicinal material and coarsely pulverize it, pass through a 20-40 mesh sieve to obtain a coarse powder;

[0029] 3) Add water 8-10 times the weight of the coarse powder to the coarse powder obtained in step 2), soak for 60-90 minutes at a water temperature of 35-40°C, then ultrasonically treat and filter to obtain the initial extract and filter residue Ⅰ , refrigerate the initial extract, and transfer the filter residue to step 4);

[0030] 4) Add ethanol with a volume ratio of 50~70% to the filter residue Ⅰ, control the weight / volume ratio of filter residue Ⅰ and ethanol to 1:7~1:10mg / mL, and extract at 35~40°C for 1.5~2 hours , filter to obtain the filtrate and filter residue II, dry the filter resi...

Embodiment 1

[0040] The invention provides a preparation method of psoraleae-free decoction preparation, which is carried out according to the following steps:

[0041] 1) Wash the psoraleae medicinal material to remove impurities, dry at 60°C, and control the water content to ≤3.0wt%;

[0042] 2) taking the dried psoralen medicinal material and coarsely pulverizing it, passing through a 30-mesh sieve to obtain a coarse powder;

[0043] 3) Add water 9 times the weight of the coarse powder to the coarse powder obtained in step 2), soak for 75 minutes at a water temperature of 37°C, and then ultrasonically treat it with a processing frequency of 25kHz, power of 400W, time of 12min, and repeat times of 3 times , filter to obtain the initial extract and filter residue I, refrigerate the initial extract, and transfer the filter residue to step 4);

[0044] 4) Add ethanol with a volume ratio of 55% to filter residue I, control the weight / volume ratio of filter residue I to ethanol to 1:8mg / mL, ...

Embodiment 2

[0047] The invention provides a preparation method of psoraleae-free decoction preparation, which is carried out according to the following steps:

[0048] 1) Wash the psoraleae medicinal material to remove impurities, vacuum-dry at 50°C, and control the water content to ≤3.0wt%;

[0049] 2) Take the dried psoralen medicinal material and coarsely pulverize it, pass through a 20-mesh sieve to obtain a coarse powder;

[0050] 3) Add water 8 times the weight of the coarse powder to the coarse powder obtained in step 2), soak for 90 minutes at a water temperature of 40°C, and then ultrasonically treat it with a processing frequency of 30kHz, power of 300W, time of 20min, and the number of repetitions is 3 times , filter to obtain the initial extract and filter residue I, refrigerate the initial extract, and transfer the filter residue to step 4);

[0051] 4) Add ethanol with a volume ratio of 70% to filter residue I, control the weight / volume ratio of filter residue I to ethanol ...

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Abstract

The invention provides a preparation method and an application of a non-decocted fructus psoraleae preparation and belongs to the technical field of traditional Chinese medicine preparation. The preparation method of the non-decocted fructus psoraleae preparation comprises steps as follows: primary extraction of effective ingredients is performed in a mode of combination of water immersion and ultrasonic extraction, secondary extraction is performed through ethanol extraction, and the non-decocted fructus psoraleae preparation is obtained through concentration, drying and superfine grinding finally. The preparation can be used for preparing a compound preparation containing fructus psoraleae or fructus psoraleae extracts. Therefore, the problem that the utilization rate of raw materials is low, the effective ingredients are severely damaged and the extraction efficiency is not high when a conventional single method is adopted for extraction are solved, the whole technological process is simple to control, synergistic interaction of the steps is realized, accordingly, the active ingredients of the fructus psoraleae are effectively protected, and the availability of a finished product is improved better.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine preparation, and in particular relates to a preparation method and application of a psoraleae-free decoction preparation. Background technique [0002] Traditional Chinese medicine is the crystallization of the wisdom of the Chinese nation and has made great contributions to the protection of people's health. The traditional dosage forms of traditional Chinese medicine include pills, powders, ointments, liquors, etc., but most of the traditional dosage forms have shortcomings such as large dosage, thick dosage form, and poor appearance. The pace of development, the introduction of high technology, and the use of new technologies to improve the quality of traditional Chinese medicine are one of the important ways to reform the formulation of traditional Chinese medicine. [0003] Psoraleae is the dry and ripe fruit of leguminous plants. It is warm in nature, pungent and bitter...

Claims

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Application Information

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IPC IPC(8): A61K36/487
Inventor 马新攀
Owner HENAN XINGZHI PATENT SERVICE CO LTD
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