Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Applications of adipokine GREM2 in preparation of obesity treatment drugs

An adipokine, therapeutic drug technology, applied in biological testing, chemiluminescence/bioluminescence, analysis by chemical reaction of materials, etc., can solve problems such as little known biological function of GREM2

Active Publication Date: 2015-12-09
RUIJIN HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
View PDF3 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It has been reported that GREM2 is related to bone formation, but little is known about the biological function of GREM2, especially in energy metabolism.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Applications of adipokine GREM2 in preparation of obesity treatment drugs
  • Applications of adipokine GREM2 in preparation of obesity treatment drugs
  • Applications of adipokine GREM2 in preparation of obesity treatment drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0017] 1. Detection of serum GREM2 levels in normal controls and obese patients

[0018] In this study, from June 2013 to August 2014, among obese patients admitted to the obesity clinic of the Department of Endocrinology, Ruijin Hospital, 167 obese patients who met the indications and were treated in this hospital were included, and 147 normal volunteers were recruited. . The inclusion criteria for obese patients are: BMI ≥ 30.0 kg / m2, aged between 14-34 years old. Exclusion criteria: 1) secondary obesity; 2) application of endocrine hormone drugs (including oral contraceptives, glucocorticoids); 3) taking hypoglycemic drugs or blood lipid-lowering drugs; 4) pregnant or lactating patients; 5) severe Of patients with abnormal liver and kidney function; 6) patients with neurological or mental diseases.

[0019] In addition, we recruited 147 normal volunteers from the students of Shanghai Jiaotong University School of Medicine. Recruitment criteria for normal people are: BMI≤23.0k...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The present invention belongs to the technical field of pharmaceutical preparation, and especially relates to applications of adipokine GREM2 in preparation of obesity treatment drugs. According to the present invention, the serum GREM2 level detection results show that the serum GREM2 level in obesity patients is significantly higher than the normal weight control, the expression profile analysis results show that the secretion factor GREM2 is mainly expressed in internal organ adipose tissue, the further in vitro primary fat precursor cell induction experiment results show that the differentiation ability of the fat precursor cell to the beige adipocyte can be significantly inhibited and the mitochondrion function can be inhibited through the overexpression of the GREM2 so as to significantly reduce the expression of the brown fat specific gene UCP1, and the effect is mediated by inhibiting the BMP / Smad signaling pathway; and the secretion factor GREM2 is mainly derived from the mature white fat cells, and it is found that the GREM2 participates into the white fat browning process, such that the GREM2 can provide new drug target for clinical obesity treatment.

Description

Technical field [0001] The invention belongs to the technical field of medicine preparation, and particularly relates to the application of adipofactor GREM2 in the preparation of obesity treatment drugs. Background technique [0002] The prevalence of obesity is increasing year by year in the world. Studies have reported that 1 / 3 of people in the United States are obese. Obesity is an important risk factor for many chronic non-communicable diseases such as type 2 diabetes, cardiovascular disease and certain tumors, which seriously endanger human health. The FDA recently approved two new weight-loss drugs aimed at reducing energy intake by suppressing appetite. Since many of the past anti-appetite weight-loss drugs have serious side effects, their application prospects are also not optimistic. Therefore, increasing energy expenditure to intervene obesity has attracted more and more attention from clinicians and basic researchers. Finding energy expenditure-related factors has be...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): G01N21/76G01N30/02G01N33/66
Inventor 宁光洪洁王计秋刘瑞欣杨明兰
Owner RUIJIN HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com