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Electrostatic spinning fiber periodontal tissue regeneration material capable of carrying medicine and production method thereof

A periodontal tissue regeneration and electrospinning technology, applied in the field of medical materials, can solve problems such as increasing the recurrence rate of periodontal disease, achieve the effect of improving surgical efficacy and promoting tissue regeneration

Inactive Publication Date: 2015-12-09
NANFANG HOSPITAL OF SOUTHERN MEDICAL UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Tissue healing after periodontal surgery often forms epithelial regeneration healing, which will increase the recurrence rate of periodontal disease

Method used

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  • Electrostatic spinning fiber periodontal tissue regeneration material capable of carrying medicine and production method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Add 3% (mass ratio) of Span 80 to chloroform, emulsify at a high speed of 7000r / min for 20 minutes, add distilled water as a solvent to prepare sodium alginate with a mass fraction of 5% (sodium alginate, M w =2×10 5 g / mol) solution, high-speed emulsification at 7000r / min for 20min, adding polylactic acid (M w =3×10 5 g / mol), prepared into a 10% emulsion, stirred for 5h, and stood for 4h. The prepared polylactic acid / sodium alginate emulsion was formed by electrospinning to prepare polylactic acid / sodium alginate composite fiber membrane. The distance between the receiving plate and the needle is about 15 cm, spinning and forming at a voltage of 18 kV, and drying the formed fiber mat in vacuum to obtain a sodium alginate-polylactic acid film. Dissolve calcium chloride in distilled water to make a 5% calcium chloride solution. Preparation of calcium alginate-polylactic acid composite film: the distance between the receiving plate and the needle is about 10cm, the vol...

Embodiment 2

[0046] Add 1% Tween 60 to a mixed solvent of dimethylacetamide: dichloromethane (1:2), emulsify at a high speed of 3000r / min for 30 minutes, add water as a solvent to prepare alginic acid with a mass fraction of 4% Sodium (M w =9×10 6 g / mol) solution, high-speed emulsification at 5000r / min for 2h, adding polylactic acid (M w =6×10 5 g / mol), formulated into a 14% emulsion, stirred for 5h, and stood for 4h. The ZnO drug is added during the preparation of the sodium alginate solution to form a drug-loading system. The prepared polylactic acid / sodium alginate emulsion is formed by centrifugal electrospinning to prepare polylactic acid / sodium alginate composite fiber membrane. The distance between the receiving plate and the needle is about 20cm, and the spinning is formed at a voltage of 35kV. The centrifugal rotation speed 400r / min, vacuum drying to obtain sodium alginate-polylactic acid film. Dissolve calcium chloride in distilled water to make a 5% calcium chloride solutio...

Embodiment 3

[0048] Add 10% PVA solution (15% concentration) to the chloroform solvent, emulsify at 3000r / min for 30 minutes, add a mixed solvent of sodium hydroxide / urea / thiourea to prepare seaweed with a mass fraction of 15% Sodium acid (M w =1×10 4 g / mol) solution, high-speed emulsification at 5000r / min for 2h, adding polylactic acid (M w =9×10 7 g / mol), formulated into a 20% emulsion, stirred for 5h, and stood for 4h. Wherein the sodium alginate solution is prepared by adding lactoferrin to form a drug loading system. The prepared polylactic acid / sodium alginate emulsion was freeze-dried to prepare a polylactic acid / sodium alginate composite material, and dried in a vacuum to obtain a sodium alginate-polylactic acid film. Dissolve calcium chloride in distilled water to make a 5% calcium chloride solution. Preparation of calcium alginate-polylactic acid composite film: the distance between the receiving plate and the needle is about 10cm, the voltage between the needle and the rece...

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Abstract

The invention aims to provide electrostatic spinning fiber periodontal tissue regeneration material capable of carrying medicine. The electrostatic spinning fiber periodontal tissue regeneration material capable of carrying medicine comprises, by weight percentage, 50-99% of polylactic acid and 1-50% of calcium alginate, wherein the polylactic acid serves as main support material, the calcium alginate serves as adjusting material for adjusting material degradation rate and improving polylactic acid degradation rate, the weight-average molecular weight of the polylactic acid is 1*10<4>-9*10<7>g / mol, and the molecular weight of the calcium alginate is 1*10<4>-9*10<6>g / mol. The electrostatic spinning fiber periodontal tissue regeneration material capable of carrying medicine has the advantages that the electrostatic spinning fiber periodontal tissue regeneration material is novel medical periodontal tissue regeneration material capable of carrying medicine, the structure features of the electrostatic spinning fiber periodontal tissue regeneration material are similar to those of pericementum fibers, material components are beneficial for bone tissue forming, and the electrostatic spinning fiber periodontal tissue regeneration material can be used to promote tissue regeneration after periodontal surgery and increase surgery curative effect.

Description

technical field [0001] The invention belongs to the field of medical materials, in particular to an anti-infection medical drug-loaded periodontal tissue regeneration material and a preparation method thereof. Background technique [0002] Since Rokkane first used PGA (polyglycolic acid) in clinical orthopedics in 1984, the experimental and clinical research of biodegradable absorbable materials has developed rapidly and achieved certain results. At present, such materials are developing rapidly in trauma orthopedics. The periodontal tissue is in the moist microenvironment of the oral cavity, the gingival crevicular fluid is constantly exuding, and there are a large number of pathogenic bacteria in the periodontal tissue. These factors cause the treatment of periodontitis to be significantly different from the treatment of traumatic bone, therefore, artificial substitute materials used in periodontal surgery are more demanding than those of traumatic bone. [0003] Commonl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/48A61L27/58D04H1/728D04H1/4382
Inventor 高杰严玉蓉沈仁泽洪舒寒赵静宜许伟鸿薛延香晋冰玉陈路沅
Owner NANFANG HOSPITAL OF SOUTHERN MEDICAL UNIV
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