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Traditional Chinese medicine used in radiology department and for preventing ographic contrast nephropathy, and preparation method

A technology for contrast agent nephropathy and radiology, applied in the direction of medical formula, medical preparations containing active ingredients, drug combinations, etc., can solve the problem that the rate is only 0.6% to 1.25%, and achieve the goal of less toxic side effects and preventive effect Effect

Inactive Publication Date: 2015-12-09
龙威
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in a group of retrospective multiple myeloma observations after receiving contrast agents, the incidence of CAN was only 0.6% to 1.25%.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0049] When the dosage form of the traditional Chinese medicine is a granule, its preparation method comprises the following steps:

[0050] Step 1: Mix the raw medicinal materials according to the stated ratio, add ethanol with an alcohol concentration of 85% to 95% relative to the mixture 4 to 8 times, heat to boiling and reflux for 3 to 5 hours, filter, and use the reflux liquid as a solvent , using the filter residue as the solute, use the percolation method to slowly percolate at a rate of 1-2ml per minute, collect the percolation liquid, and then concentrate it under reduced pressure at a vacuum of 0.06-0.09Mpa to 50-60°C with a relative density of 1.04 ~1.10 paste, spray drying, the air inlet temperature of the spray dryer is 160~175℃, and the air outlet temperature is 80~85℃, and then crushed into powder to make dry paste powder;

[0051] Step 2: Add 0.2-0.4 times of sucrose powder and 0.1-0.2 times of dextrin to the obtained dry cream powder to form granules, and dry ...

Embodiment 1

[0060] Embodiment 1: Granules

[0061] Take 160g a little red, 200g yellow hibiscus, 120g feilian, 250g goosefoot, 200g red onion, 180g bean tree, 190g vitex, 250g wild horseshoe grass, 150g bitter dish, 120g red head grass, 230g nasturtium, and pandanus 170g of flowers, 260g of lotus bean vegetables, 280g of bristle grass, 150g of halogen alkali, 250g of vines, 130g of golden fruit olives and 150g of Dinggui grass;

[0062] Its preparation method comprises the following steps:

[0063] Step 1: Mix the raw medicinal materials according to the stated ratio, add ethanol with an alcohol concentration of 90% which is 5 times that of the mixture, heat to boiling and reflux for 4 hours, filter, use the reflux liquid as the solvent, and use the filter residue as the solute, using The percolation method slowly percolates at a rate of 2ml per minute, collects the percolation liquid, and then concentrates it under reduced pressure at a vacuum of 0.08Mpa to a paste with a relative densi...

Embodiment 2

[0065] Embodiment 2: oral liquid

[0066] Take 180g a little red, 180g yellow hibiscus, 140g feilian, 230g goosefoot, 220g red onion, 150g bean tree, 210g vitex, 220g wild calla, 160g bitter dish, 90g red head grass, 260g nasturtium, and pandanus 140g of flowers, 280g of lotus bean vegetables, 250g of bristle grass, 180g of halogen alkali, 220g of cow vine, 160g of golden fruit olive and 120g of Dinggui grass;

[0067] Its preparation method comprises the following steps:

[0068] In the first step, add a little red, yellow hibiscus, feilian, goosefoot, red onion, bean tree, vitex, wild horseshoe grass, bitter saucer and red head grass, and add 3.5 times the amount of alcohol concentration of 65% relative to the mixture Reflux extraction with ethanol for 3 times, each time for 2 hours, filter, combine the filtrates, recover ethanol, concentrate to a paste with a relative density of 1.31 at 70°C, and set aside;

[0069] In the second step, mix the remaining raw medicinal mate...

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PUM

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Abstract

The invention provides a traditional Chinese medicine used in the radiology department and for preventing radiographic contrast nephropathy, and a preparation method of the traditional Chinese medicine. The traditional Chinese medicine comprises the following raw herbal materials: emilia sonchifolia, hibiscus tiliaceus, welted thistle, herb of diversifolious pimpinella, american eleutherine rhizome, radermachera sinica, fructus viticis, herb of rush-like bulrush, sowthistle-leaf ixeris seedling, blumea, trollflower, textile screw pine flower, herba drymariae, herb of maidenhair, alkali halide, flexuose climbing fern, radix tinosporae and zornia diphylla pers. The traditional Chinese medicine provided by the invention has the following beneficial effects: the traditional Chinese medicine has an exact effect on preventing radiographic contrast nephropathy, and has little toxic or side effect.

Description

technical field [0001] The invention relates to a medical preparation containing components derived from plants, animals or minerals, in particular to a traditional Chinese medicine used in radiology for preventing contrast medium nephropathy and a preparation method thereof. Background technique [0002] With the widespread development of modern imaging techniques, contrast-induced nephropathy (contrastassociated nephropathy, CAN) has been increasingly concerned by nephrologists. CAN refers to a sudden decrease in renal function caused by contrast media. Commonly used contrast agents are generally hypertonic, with iodine content as high as 37%. In the body, they are filtered by the glomeruli in their original form and not absorbed by the renal tubules. When dehydrated, the concentration of the drug in the kidney increases, which can cause kidney damage. Acute renal failure occurs. Reports of acute renal failure caused by contrast agents are increasing day by day, and even...

Claims

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Application Information

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IPC IPC(8): A61K36/89A61P13/12A61K33/14
Inventor 龙威陆继香
Owner 龙威
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