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Compound dipyridamole and aspirin tablet and preparation method thereof

A technology for dipyridamole aspirin and dipyridamole tablet cores is applied in compound tablets and their preparation, and in the field of compound dipyridamole aspirin tablets and their preparation, and can solve gastric wall mucosal damage, unfavorable long-term medication, unfavorable Amplify production and other issues to achieve the effects of improving solubility and absorption, improving bioavailability, and improving placement stability

Inactive Publication Date: 2015-12-02
HEBEI ZHITONG BIOLOGICAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The rapid release of aspirin as a coating layer will cause certain damage to the gastric wall mucosa, which is not conducive to the long-term administration of this preparation
This preparation process has several problems: (1) aspirin is coated by a coating pan, and the solvent is water, which is unfavorable for the stability of aspirin
(2) The aspirin coating prescription contains tartaric acid. Due to the large amount of solutes, dust will fly during the coating process, which is not conducive to labor protection. The degree will have a greater impact, which is not conducive to the scale-up of production
However, acidic substances should not be too much, which will cause damage to the gastric mucosa and cause gastric diseases

Method used

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  • Compound dipyridamole and aspirin tablet and preparation method thereof
  • Compound dipyridamole and aspirin tablet and preparation method thereof
  • Compound dipyridamole and aspirin tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] Example 1 Compound dipyridamole aspirin tablet of the present invention (specification: 200mg / 25mg, 1000 tablets)

[0054] Prescription composition:

[0055] (1) Dipyridamole extended-release part

[0056]

[0057] (2) Aspirin part

[0058]

[0059]

[0060] (3) The outer part of the tablet

[0061] HPMC17B type coating powder 15g.

[0062] The preparation method comprises the steps of:

[0063] (1) Preparation of dipyridamole tablet core

[0064] A, get the dipyridamole of recipe quantity, acidic additive (1), 20% sustained-release retardant and cross 80 mesh sieves and mix homogeneously, and material is for subsequent use;

[0065] B, remaining 80% slow-release retarder is mixed with slow-release retarder weight percent is 5% 70% ethanol aqueous solution, and solution is for subsequent use;

[0066] C. Mix the material obtained in step A with the solution obtained in step B to make a soft material. After passing through a 20-mesh sieve, place it in an o...

Embodiment 2

[0076] Example 2 Compound dipyridamole aspirin tablet of the present invention (specification: 200mg / 25mg, 1000 tablets)

[0077] Prescription composition:

[0078] (1) Dipyridamole extended-release part

[0079]

[0080]

[0081] (2) Aspirin part

[0082]

[0083] (3) The outer part of the tablet

[0084] HPMC17B type coating powder 18g

[0085] The preparation method comprises the steps of:

[0086] (1) Preparation of dipyridamole tablet core

[0087] A, get the dipyridamole of recipe quantity, acidic additive (1), 20% sustained-release retardant and cross 80 mesh sieves and mix homogeneously, and material is for subsequent use;

[0088] B, remaining 80% slow-release retarder is mixed with slow-release retarder weight percentage is 10% 70% ethanol aqueous solution, and solution is for subsequent use;

[0089] C. Mix the material obtained in step A with the solution obtained in step B to make a soft material. After passing through a 20-mesh sieve, place it in a...

Embodiment 3

[0099] Example 3 Compound dipyridamole aspirin tablet of the present invention (specification: 200mg / 25mg, 1000 tablets)

[0100] Prescription composition:

[0101] (1) Dipyridamole part

[0102]

[0103] (2) Aspirin part

[0104]

[0105] (3) The outer part of the tablet

[0106] HPMC17B type coating powder 12g;

[0107] The preparation method comprises the steps of:

[0108] (1) Preparation of dipyridamole tablet core

[0109] A, get the dipyridamole of recipe quantity, acidic additive (1), 20% sustained-release retardant and cross 80 mesh sieves and mix homogeneously, and material is for subsequent use;

[0110] B, remaining 80% slow-release retarder is mixed with slow-release retarder weight percent is 1% 70% ethanol aqueous solution, and solution is for subsequent use;

[0111] C. Mix the material obtained in step A with the solution obtained in step B to make a soft material. After passing through a 20-mesh sieve, place it in an oven and dry it at 40°C for 4 ...

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Abstract

The invention relates to a compound dipyridamole and aspirin tablet and a preparation method thereof, and belongs to the technical field of medicine preparations. The tablet adopts a two-layer tablet which contains a dipyridamole tablet core and an aspirin tablet core and releases dipyridamole and aspirin in different portions, wherein the dipyridamole is slowly released for 12 h, and the aspirin is quickly released in the intestinal fluid. According to the tablet, the solubility and absorption degree of the dipyridamole in the gastrointestinal fluid can be significantly improved to improve the bioavailability of the dipyridamole, generation of relative substances can be effectively inhibited, the aspirin can be primarily and quickly released in the intestines to achieve the effect, the dipyridamole can be slowly released to achieve a long-acting effect, and therefore the treatment purpose of cooperative administration through slow releasing of the dipyridamole and quick releasing of the aspirin is achieved.

Description

technical field [0001] The invention relates to a compound tablet and a preparation method thereof, in particular to a compound dipyridamole aspirin tablet and a preparation method thereof, belonging to the technical field of pharmaceutical preparations. Background technique [0002] The compound dipyridamole aspirin tablet is an anti-blood coagulation preparation, and the compound combination has been protected by the US patent (Grinnell, et al, NO60 / 048,628, 1997.06.05). [0003] Domestically imported preparations include dipyridamole / aspirin compound sustained-release capsules from Boehringer Ingelheim, Germany, which were approved by the FDA in 1999. The specification is (200mg / 25mg, English name: Aggrenox), which is used for the treatment of mild cerebral infarction. Its preparation is made by co-filling dipyridamole pellets and aspirin sugar-coated tablets in capsules. The preparation process of this process is designed for the design of pellets and coated tablets. The...

Claims

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Application Information

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IPC IPC(8): A61K31/616A61K31/519A61K9/22A61K9/28A61P7/02
Inventor 孙树玲赵峰田亚平郭艳丽刘科攀赵云超何庆国
Owner HEBEI ZHITONG BIOLOGICAL PHARMA
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