Zhengtian pill mixing process end point determination method

Abstract

The invention provides a Zhengtian pill mixing process end point determination method. The method comprises the steps of stratified sampling in the mixing process, near infrared spectrum collecting for a sample in the mixing process, mixing uniformity calculating through variable coefficients, spectrum pretreating and waveband selecting, mixing end point judging through principal component analysis and mahalanobis distance and Zhengtian pill mixing end point time determining. According to the Zhengtian pill mixing process end point determination method, a near infrared online analysis technology is introduced into the Zhengtian pill mixing process, and therefore evaluation on the mixing uniformity of powder is achieved; the method is reasonable in design and beneficial for improving the quality control level of the Zhengtian pill mixing process, and it can be adequately guaranteed that the product quality is stable and reliable; quick and in-time judgment on the mixing uniformity and a mixing end point in the Zhengtian pill mixing process is achieved, improvement of the production efficiency is facilitated, the production quality is guaranteed, and great realistic significance is achieved for traditional Chinese medicine industry technical progress and product quality upgrade.

Description

technical field [0001] The invention belongs to the field of near-infrared on-line detection, and in particular relates to a method for measuring the mixing uniformity and the mixing end point in the mixing process of Zhengtian pills. Background technique [0002] Zhengtian Pill is a Chinese patent medicine widely used in the treatment of tension headache, nervous headache and other headaches. It mainly includes 15 medicinal materials such as Uncaria, Paeoniae Alba, Rhizoma Chuanxiong, Angelica, Rehmannia, Angelica, Fangfeng, Notopterygium, Peach Kernel, and Safflower. The mixing process is a key process link in the production process of Zhengtian pills. Its main purpose is to mix more than a dozen kinds of medicinal powders evenly to ensure the uniformity and stability of the active ingredients in the pills. The traditional mixing process mainly relies on the experience of the operator, which is time-consuming and labor-intensive, and there is no unified standard for discr...

AI Technical Summary

Problems solved by technology

The traditional mixing process mainly relies on the experience of the operator, which is time-consuming and labor-intensive, and there is no unified standard for discrimination, resulting in unstable quality

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