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Prussian blue-based smart pH-triggered MRI-monitored drug release synergistic nano-therapeutic agent and its preparation method

A Prussian blue and nanotechnology, applied in the field of nanomaterials and biomedical materials, to achieve the effect of excellent light-to-heat conversion performance

Active Publication Date: 2017-11-10
SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, on the basis of the hollow mesoporous Prussian blue introduced with T 1 Contrast-weighted MRI features of manganese ions have not been reported

Method used

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  • Prussian blue-based smart pH-triggered MRI-monitored drug release synergistic nano-therapeutic agent and its preparation method
  • Prussian blue-based smart pH-triggered MRI-monitored drug release synergistic nano-therapeutic agent and its preparation method
  • Prussian blue-based smart pH-triggered MRI-monitored drug release synergistic nano-therapeutic agent and its preparation method

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preparation example Construction

[0052] figure 1 A schematic diagram showing an exemplary preparation method of the present invention. The preparation method of the nano-diagnostic agent of the present invention comprises: using potassium ferricyanide as a raw material to prepare a hollow mesoporous Prussian blue nanocube (HMPB) template, and preparing a hollow mesoporous nanoparticle (HMPB-Mn) based on Prussian blue with a core-shell. However, the method for preparing HMPB is not limited, and various known methods can be used. In one example, the preparation method of HMPB can comprise the following steps:

[0053] A) According to the mass ratio, add 0.132-0.396 parts of potassium ferricyanide and 2-10 parts of polyvinylpyrrolidone into 30-100 parts of acid (such as 0.01-2M hydrochloric acid), mix and stir evenly, and age at 60-100 °C After cooling, separate and wash to obtain Prussian blue nanoparticles with mesoporous pores;

[0054] B) Disperse the obtained mesoporous Prussian blue nanoparticles in 50-...

Embodiment 1

[0080] Weigh 132mg of iron (III) potassium cyanide and 3g of polyvinylpyrrolidone K~30 (PVP) in 40mL of 0.01M hydrochloric acid, stir for 30min to fully dissolve to form a yellow transparent solution, and place it in an oven at 80°C for 20h. Centrifuge at 11000r / min for 10min and wash once with water to obtain mesoporous Prussian blue nanoparticles (MPB). MPB was dissolved in 20mL of 1M hydrochloric acid to disperse evenly, hydrothermally etched at 140°C for 4h, centrifuged at 11000r / min for 10min, washed once with water to obtain hollow mesoporous Prussian blue (HMPB) and dried for later use;

[0081] After etching with 1M hydrochloric acid, a hollow structure is formed, the particle size remains basically unchanged, the dispersion is good, and the shell wall thickness of the hollow structure is 10-100nm;

[0082] Next, 4.4 mg of manganese acetate, 11.4 mg of sodium citrate, 500 mg of PVP, 10 mg of HMPB and water were magnetically stirred to obtain a clear solution. Dissolve...

Embodiment 2

[0085] The HMPB-Mn obtained in Example 1 is dispersed in PBS, and its absorption peak at the near-infrared light is measured with a UV-Vis spectrophotometer, as shown in Figure 4 As shown (wherein HMPB-Mn 11 means that the molar ratio of iron and manganese is 11:1, and HMPB-Mn 5.5 means that the molar ratio of iron and manganese is 5.5:1), it can be seen that the prepared material has a relatively high performance in the near-infrared region. Strong and broad absorption peak, the strongest around 720nm.

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Abstract

The present invention relates to a Prussian blue-based intelligent pH-triggered MRI-monitored drug release synergistic nano therapeutic agent and a preparation method thereof. The nano therapeutic agent includes Prussian blue nanoparticles with mesoporous and hollow interior, and the hollow mesoporous Prussian blue KxMny[Fe(CN)6]z coated on the surface of the nanoparticle, wherein 0.05≤x≤0.3, 0.5≤y≤0.98, z=1, the nanomedicine is formed as a hollow mesoporous nanoparticle with a core-shell structure. The HMPB-Mn nano-diagnosis and treatment agent of the present invention has the functions of pH-responsive nuclear magnetic resonance imaging and pH-responsive drug release for chemotherapy at the tumor site, and combined with hyperthermia at the same time, realizing the combination of hyperthermia and chemotherapy under the guidance of nuclear magnetic resonance imaging to treat tumors.

Description

technical field [0001] The invention relates to the technical field of nanomaterials and the field of biomedical materials, in particular to a nano-diagnostic and therapeutic agent based on hollow mesoporous Prussian blue pH-responsive nuclear magnetic resonance imaging (MRI) and photoacoustic imaging under the guidance of dual modes of hyperthermia and chemotherapy for synergistic treatment of tumors and its preparation method. Background technique [0002] Magnetic resonance imaging is a non-invasive imaging method with high resolution and the ability to obtain anatomical and physiological information. It is widely used in the field of diagnosis and treatment. Currently in clinical practice, T 1 weighted contrast ratio T 2 Weighted contrast agents have more advantages, such as it is difficult to distinguish some dark spots due to T 2 The effect of the contrast agent is still caused by blood calcification, metal deposition, or some other background signals. Currently us...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K49/06A61K41/00A61K49/00A61K31/704A61K48/00A61P35/00
Inventor 蔡晓军陈航榕施剑林
Owner SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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