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Strain of bifidobacterium animalis ssp. animalis

A technology of animal Bifidobacterium and Bifidobacterium breve, applied in the direction of Bifidobacteria, microorganisms, microorganisms, etc., can solve the problems of increased mRNA expression, increased small intestine and colon myoelectric activity, VIP concentration has no significant effect, etc.

Active Publication Date: 2015-11-04
DANONE
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Metugriachuk et al. (Rejuvenation Res., 9:342-345, 2006) disclosed that symbiotic preparations on the motility of the small and large intestines of aged Wistar rats significantly increased the myoelectric activity of the small and colon and led to VIP mRNA expression increased, but had no significant effect on VIP concentration

Method used

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  • Strain of bifidobacterium animalis ssp. animalis
  • Strain of bifidobacterium animalis ssp. animalis

Examples

Experimental program
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Effect test

Embodiment 1

[0031] Example 1: Effect of lactic acid bacteria on neuronal VIP production in a co-culture model of ENS primary cultures and T84 cells

[0032] investigated the differential response of primary enteric neurons to VIP production after interacting with 107 probiotic strains, including lactic acid bacteria, especially bifidobacteria.

[0033] Bacterial Strains and Growth Conditions

[0034] Lactobacilli were grown in Man, Rogosa and Sharpe (MRS) medium (Biokar Diagnostics, Beauvais, France) at 37°C for 24 hours under aerobic conditions.

[0035] Bifidobacteria were cultured in a defined medium consisting of tryptone (Becton Dickinson, France) supplemented with glucose (Sigma, France), yeast extract (Becton Dickinson, USA) and hemin (Calbiochem, France). USA) and grown under anaerobic conditions at 37°C for 24 hours. Bifidobacterium animalis subsp. lactobacillus was cultured in MRS medium (Biokar Diagnostics) supplemented with cysteine ​​(Sigma, France) and grown under anaerobi...

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Abstract

The invention relates to a novel strain of Bifidobacterium animals ssp. animalis, which is able, inter alia, to improve the function of the enteric nervous system, and to compositions said novel strain.

Description

technical field [0001] The invention relates to a novel animal bifidobacterium animalis subspecies (Bifidobacterium animalis ssp. animalis) bacterial strain. This strain is especially capable of improving the function of the enteric nervous system (ENS) by increasing the level of vasoactive intestinal peptide (VIP) in the enteric nervous system (ENS), for example to promote functions of intestinal motility or barrier integrity. Therefore, this strain is useful for preventing and / or alleviating gastrointestinal discomfort or gastrointestinal diseases. Background technique [0002] The enteric nervous system (ENS) is an integrated nervous system that forms 2 major nerve plexuses with function-specific roles along the intestinal tract (Furness, J. Auton. Nerv. Syst., 81(1-3):87- 96, 2000). The myenteric plexus, located between the longitudinal and circular muscles, contains neurons primarily involved in the control of gastrointestinal (GI) motility. The submucosal plexus, lo...

Claims

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Application Information

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IPC IPC(8): A61K35/74C12R1/01A23C9/12
CPCA61K35/745A23C9/1234A23L1/3014A23Y2300/21A61K35/00A61K35/747C12R1/01A23L33/135A61P1/04A61P1/10A61P1/14A61P31/00A61P43/00C12R2001/01C12N1/205A23V2400/515
Inventor 索菲·勒格兰-拉斯波詹弗兰科·格龙波内桑德兰·卡普罗尼耶塔玛拉·什莫克维纳玛丽-克里斯蒂娜·德吉弗里比里亚纳·莱西奇米歇尔·伊诺恩利斯特
Owner DANONE
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