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Tibetan artemisia capillaris extract and preparation method, drug composition and application thereof

A technology for extracts and compositions, applied in the field of extracts and their preparations of Cannabis chinensis, can solve the problems of purification and identification limitations, influence research and application, etc., and achieve the effects of good liver and gallbladder relief, easy quality control, and concentrated effective components.

Inactive Publication Date: 2015-10-14
MINZU UNIVERSITY OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the large number of plants from which Yinchen is derived, the existing technology has been greatly limited in the purification and identification of its active ingredients, which has affected its clinical research and application.

Method used

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  • Tibetan artemisia capillaris extract and preparation method, drug composition and application thereof
  • Tibetan artemisia capillaris extract and preparation method, drug composition and application thereof
  • Tibetan artemisia capillaris extract and preparation method, drug composition and application thereof

Examples

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preparation example Construction

[0043] The present invention secondly provides the preparation method of the described Capillary chinensis extract, and the described method comprises:

[0044] 1) Grinding or cutting off the long-stemmed laryngeal hair flower medicinal material, heating and refluxing with ethanol for 2-4 times, combining the extracts, concentrating to obtain a concentrated solution, and diluting with water; and

[0045] 2) extracting the diluent obtained in step 1) with petroleum ether, and separating to obtain the lower layer of water; and

[0046] 3) Adsorb the lower aqueous solution obtained in step 2) through an AB-8 macroporous resin column, then elute with 2-6 times the volume of 10-30% ethanol, and then use 6-10 times the volume of 50-70 % ethanol solution for elution, collecting 50-70% ethanol eluate, and concentrating under reduced pressure, so as to obtain the extract of the fungi.

[0047] Preferably, in step 3), after being adsorbed by the AB-8 type macroporous resin column, it i...

Embodiment 1

[0078] Grinding the raw material of the dried medicinal material of C. chinensis, heating and refluxing with 5 times the amount of 75% ethanol to extract twice for 2 hours each time, combining the extracts, and concentrating under reduced pressure to obtain a concentrated solution. Dilute the concentrate with 2 times the amount of water. Add 4 times the amount of water to the concentrated solution to fully suspend, extract twice with 1:1 volume of petroleum ether, and separate the lower layer of water. The water in the lower layer was eluted through a macroporous resin column according to the amount of resin and medicinal material at 1:1, first eluted with 4 times the volume of 20% ethanol, and then eluted with 8 times the volume of 60% ethanol solution, and collected 60% ethanol The eluate was concentrated under reduced pressure at 60°C, and dried to constant weight to obtain the extract of Yinchen cypress. After identification of its components, it was shown that its main ch...

Embodiment 2

[0084] Grind the dry raw material Swertia japonica, heat and reflux extract with 5 times the amount of 70% ethanol for 2 times, each time for 2 hours, combine the extracts, concentrate under reduced pressure, dilute the concentrated solution with 10 times the amount of water, according to the amount of resin and medicinal materials Amount 1:1 was eluted by AB-8 type macroporous resin column, first eluted with 4 times the volume of 20% ethanol, and then eluted with 8 times the volume of 70% ethanol solution, collected the 70% ethanol eluate, 60 °C, concentrated under reduced pressure, and dried to constant weight, so as to obtain the extract of Yinchen Tibetan. The main active ingredients are Ketones and iridoids, including: gentione, 1,3,8-trihydroxy-5-methoxy Ketone, 1,3,5,8-tetrahydroxy- Ketones, swertiamarin, swertiroside, etc.

[0085] The obtained Swertia chinensis extract was mixed with the extract of Yinchen Tibetan in Example 1 at a weight ratio of 1:1 to obtain ...

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Abstract

The invention discloses a Tibetan artemisia capillaris extract, a preparation method, a drug composition and an application thereof. The Tibetan artemisia capillaris is Comastoma Pedunculatum[Rogle ex D.Dou]Holub. The Tibetan artemisia capillaris extract includes at least 25% by weight of Tibetan artemisia capillaries total flavonoid glycoside. Compared with a drug composition in the prior art, the drug composition has following advantages: the Tibetan artemisia capillaris extract is high in extraction efficiency, is concentrated in effective components, is simple in steps, is low in energy consumption and less in cost, is high in effective components, is less in impurities and is convenient to control in quality, has the effects of clearing heat and removing toxin, and dispelling liver and draining bile, and can be used for treating various acute and chronic hepatitis.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, and in particular relates to a Tibetan fungus extract, its preparation method, pharmaceutical composition and application. Background technique [0002] Tibetan medicine is one of the few ethnic medicines with its own unique theoretical system. Its content is rich and systematic, and it is a complete ethnic medical system second only to traditional Chinese medicine. Tibetan medicine has unique diagnosis and treatment methods and proven prescriptions for various acute and chronic diseases and difficult diseases such as liver and gallbladder diseases, and has accumulated rich clinical experience and prescriptions. Among them, Tibetan Yinchen plants are one of the most commonly used drugs for treating liver and gallbladder diseases in Tibetan medicine. [0003] Tibetan Yinchen is a traditional Tibetan medicine that grows in alpine regions. It is one of the eight treasures of Tibetan medic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/51A61P1/16A61P31/20A61P31/14
Inventor 唐丽崔勋崔箭
Owner MINZU UNIVERSITY OF CHINA
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