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Fiber film coated with gold nanorods, and preparation method and application thereof

A technology of gold nanorods and fiber membranes, applied to medical preparations with non-active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, etc., can solve the problem of not using gold nanorods and other nanomaterials, and achieve tumor recurrence preventive effect

Inactive Publication Date: 2015-09-09
INST OF CHEM CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no report on biodegradable membranes embedded with nanomaterials for tumor therapy.
In addition, although drug sustained release strategies have been widely used in cancer treatment and recurrence prevention, they have not been applied to nanomaterials such as gold nanorods.

Method used

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  • Fiber film coated with gold nanorods, and preparation method and application thereof
  • Fiber film coated with gold nanorods, and preparation method and application thereof
  • Fiber film coated with gold nanorods, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] 1) Disperse gold nanorods in dimethylformamide (DMF) solution to prepare an organic solution of gold nanorods with a concentration of 34.8 μg / mL. After ultrasonication at 480W for 10 minutes, stir at room temperature for 2 hours to obtain An organic solution of gold nanorods;

[0044] 2) Combine polylactic-co-glycolic acid (PLGA) with a weight-average molecular weight of 60,000, LA / GA (that is, the molar ratio of lactic acid and glycolic acid) = 75 / 25, and a weight-average molecular weight of 10,000, LA / EG=50 / 50 poly(lactic acid-ethylene glycol) copolymer (PLA-b-PEG) was dissolved in the organic solution of gold nanorods obtained in step 1) at a mass ratio of 85:15, to PLGA and PLA-b-PEG The total mass percentage concentration is 50%, and the spinning solution is obtained.

[0045] 3) Inject the spinning solution obtained in step 2) into a 5ml syringe, add a No. 5 stainless steel needle (the inner diameter of the needle hole is 2.6mm), and conduct electrostatic under ...

Embodiment 2

[0049] 1) Disperse gold nanorods in dimethylformamide (DMF) solution to prepare an organic solution of gold nanorods with a concentration of 34.8 μg / mL, ultrasonicate at 400W for 20 minutes, and stir at room temperature for 6 hours to obtain An organic solution of gold nanorods;

[0050] 2) Copolymerize polylactic acid-glycolic acid copolymer (PLGA) with a weight average molecular weight of 80,000 and LA / GA=75 / 25 with poly(lactic acid-ethylene glycol) with a weight average molecular weight of 20,000 and LA / EG=50 / 50 The material (PLA-b-PEG) was dissolved in the organic solution of gold nanorods obtained in step 1) at a mass ratio of 95:5, until the total mass percentage concentration of PLGA and PLA-b-PEG was 60%, and the spun silk liquid.

[0051] 3) Inject the spinning solution obtained in step 2) into a 5ml syringe, add a No. 5 stainless steel needle (the inner diameter of the needle hole is 2.6mm), and conduct electrostatic under the conditions of a voltage of 25KV, a prop...

Embodiment 3

[0054] Example 3, Sustained release of electrospun fiber membranes loaded with gold nanorods

[0055] The electrospun fiber membranes loaded with gold nanorods prepared in Example 1 and Example 2 were cut into 2 × 2 cm 2 Thin slices were placed in 10 mL of FBS-containing DMEM medium, wherein the volume ratio of FBS to DMEM was 1:10. At different time nodes (1 day, 10 days, 20 days, 30 days, 40 days, 50 days, 60 days, 70 days, 80 days, 90 days), 2 mL of medium was removed and 2 mL of fresh medium containing 10 DMEM medium with %FBS. Finally, ICP-MS was used to measure the mass percentage of gold in the extracted solution, and then the released mass was divided by the total embedded mass to obtain the percentage, so as to obtain the release curve.

[0056] The resulting release curve was Figure 4 shown.

[0057] It can be seen from the figure that the electrospun fiber membrane has the property of rapidly releasing about 30% of gold nanorods within 1 day, and the remaining ...

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Abstract

The invention discloses a fiber film coated with gold nanorods, and a preparation method and an application thereof. The fiber film coated with the gold nanorods is composed of PEG surface modified gold nanorods and a fiber film; the gold nanorods are evenly distributed in the fiber film. Based on the PEG surface modified gold nanorods, local high temperature of a tumor part is caused by extremely-high photo-thermal conversion efficiency, tumor cells can be effectively killed, and moreover, with utilization of high biocompatibility of the biodegradable electrospinning fiber film, the electrospinning fiber film is used as a carrier of the gold nanorods and a postoperation recovery material. The electrospinning fiber film can directly act on affected parts, and has a characteristic of regulating and controlling release according to the component ratio to achieve the purpose of slow-release treatment, so as to prevent tumor recurrence after tumor operation.

Description

technical field [0001] The invention belongs to the field of biomedical devices, and in particular relates to a fiber membrane loaded with gold nanorods and a preparation method and application thereof. Background technique [0002] Photothermal therapy has become a promising tumor treatment modality by converting light energy into heat energy to cause cell death. Tumor cells are more sensitive to thermal damage because the local blood supply of tumor tissue is insufficient and it is not conducive to heat dissipation. Therefore, compared with traditional chemotherapy and radiotherapy, which have serious side effects, photothermal therapy has the advantage of specifically killing tumor cells while having less impact on nearby normal cells. Recently, with the development of plasmonic nanomaterials, their strong light absorption efficiency has promoted the application of photothermal therapy in local hyperthermia. Among such materials, PEG-surface-modified gold nanorods (PEG-...

Claims

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Application Information

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IPC IPC(8): A61K41/00A61K47/48A61K47/34A61K47/32A61K9/70A61P35/00A61L31/16A61L31/04A61L31/06
Inventor 方晓红程茗王赫然许杉杉
Owner INST OF CHEM CHINESE ACAD OF SCI
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