Method for cleaning ultrafiltration membrane bag

A technology for ultrafiltration membrane package and cleaning system, applied in ultrafiltration, chemical instruments and methods, membrane technology, etc., can solve the problems of clogging of membrane pores, cumbersome detection of membrane package integrity, membrane package pollution, etc., and achieve the cleaning time. Reduction, excellent cleaning effect, surface tension reduction effect

Active Publication Date: 2015-08-26
SINOVAC BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The filter membrane is a special polymer structure. Due to the high frequency of cleaning, regeneration, and repeated use during use, membrane pore blockage, membrane penetration, membrane leakage, and membrane bag pollution will occur, which may easily lead to bacterial toxicity or biological activity. Leakage of ingredients, resulting in loss of antigens or environmental contamination
At present, the integrity detection of filter membrane fibers mostly depends on the detection method of the ultrafiltration membrane bag manufacturer. The ultrafiltration membrane bag is cleaned and regenerated after repeated use. The manufacturer recommends that the membrane bag can still be used after the membrane integrity tester is used to detect the integrity of the membrane bag. , and in actual application, the ultrafiltration membrane bag is cleaned and regenerated after repeated use, and then treated with the cleaning method and testing procedure given by the manufacturer, and the qualified membrane bag is tested again. In addition, it is cumbersome to use instruments to detect the integrity of the membrane package, and the membrane package needs to be disassembled repeatedly. This method is not suitable for the field of biological product preparation that requires continuous production.

Method used

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  • Method for cleaning ultrafiltration membrane bag

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] The method (1) of embodiment 1 cleaning ultrafiltration membrane bag

[0032] Take out the new membrane package from the mixed preservation solution of alkali and glycerin, and rinse with purified water to remove the surface alkali solution. Install the cleaned membrane bag into the ultrafiltration fixture, and install pressure gauges at the inlet and return ends respectively to detect the pressure during operation.

[0033] cleaning:

[0034] (1) Alkali-salt mixed liquid circulation cleaning:

[0035] A mixed solution of 0.1 mol / L sodium hydroxide, 5% Tween 80 and 0.25% sodium hypochlorite alkali salt was prepared at a temperature of 40°C. The alkali-salt mixture is connected to the liquid inlet end of the ultrafiltration system through a pipeline, and the pressure of the liquid inlet end of the ultrafiltration system is controlled at 15 psi by controlling the pump speed of the peristaltic pump, and the pressure at the return end is controlled at 2 psi. Ensure that ...

Embodiment 2

[0043]The method (2) of embodiment 2 cleaning ultrafiltration membrane bag

[0044] Take the repeatedly used ultrafiltration membrane package out of the preservation solution and rinse it with purified water. Install the cleaned membrane bag into the ultrafiltration fixture, and install pressure gauges at the inlet and return ends respectively to detect the pressure during operation.

[0045] cleaning:

[0046] (1) Alkali-salt mixed liquid circulation cleaning:

[0047] Prepare 1.0mol / L sodium hydroxide, 3% Tween 80 and 0.3% sodium hypochlorite alkali salt mixture at 30°C. The alkali-salt mixture is connected to the liquid inlet of the ultrafiltration system through a pipeline, and the pressure of the liquid inlet of the ultrafiltration system is controlled at 20 psi by controlling the pump speed of the peristaltic pump, and the pressure at the return end is controlled at 3 psi. Ensure that the pressure at the inlet and return ends is stable within the above pressure range,...

Embodiment 3

[0055] Using the ultrafiltration membrane bag newly purchased from P company, according to the method of cleaning the ultrafiltration membrane bag guided by the manufacturer and the cleaning method of the present invention, a comparative test is carried out. After each production and use, the ultrafiltration membrane bag is cleaned and the water flow rate is detected. The manufacturer The guidance is that when the water flux of the ultrafiltration membrane is ≥70%, the ultrafiltration membrane can be used continuously, and when the water flux of the ultrafiltration membrane is <70%, it is recommended to discard the ultrafiltration membrane. The comparative test results are shown in Table 1:

[0056] Table 1 The method of the present invention and manufacturer's instruction method clean ultrafiltration membrane bag effect comparison

[0057]

[0058] It can be seen from the above table that the water flux of the new membrane bag after cleaning according to the manufacturer's...

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Abstract

The present invention provides a method for cleaning an ultrafiltration membrane bag, and belongs to the field of filter membrane cleaning methods. Hot alkali salt mixed solution is use d for cycling washing of the ultrafiltration membrane bag; PBS buffer is used for washing balance; by controlling the pressure in the operation, the integrity of membrane bag is ensured in the operation, so as to achieve the purpose of impurity removal from the membrane bag. The method of the invention is simple and easy to control; the used solutions are commonly used in vaccine production process, do not increase the risk of product quality and safety; the method can effectively remove impurities in ultrafiltration membrane bag, increase the average water flow, reduce the risks of membrane penetration and membrane leakage in the dialysis and concentration processes, and effectively prevent product loss, environmental pollution and operator hazardous incidents due to leakage; and the method can be widely used in the field of preparation of vaccines, improves production efficiency, reduce production costs, and achieve good economic value.

Description

technical field [0001] The invention relates to a method for cleaning an ultrafiltration membrane bag. Background technique [0002] Ultrafiltration is a kind of membrane separation technology. It is a process driven by pressure difference. Its separation mechanism is to rely on stable pressure and flow rate to achieve sieving through the membrane aperture, and to separate at the molecular level, forcing small molecular components to are filtered out and macromolecules are retained. Since ultrafiltration can be completed at room temperature without adding other substances, the membrane separation system is composed of membrane modules with different retention characteristics to separate, concentrate, and purify the active ingredients, so ultrafiltration membranes are widely used in environmental protection, food, and medicine. and other fields. [0003] At present, in the production of biological products, ultrafiltration has shown significant technical advantages. The ul...

Claims

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Application Information

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IPC IPC(8): B01D65/02B01D61/14
Inventor 张健张颖马敏华张星星李静尹卫东
Owner SINOVAC BIOTECH
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