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Oral care composition containing ionic liquids

An ionic liquid and oral care technology, applied in the field of oral care compositions containing ionic liquid, can solve problems such as increasing drug resistance

Inactive Publication Date: 2015-08-19
COLGATE PALMOLIVE CO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, bacteria present in biofilm or plaque sediments show an increased drug resistance

Method used

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  • Oral care composition containing ionic liquids
  • Oral care composition containing ionic liquids
  • Oral care composition containing ionic liquids

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0337] Example 1: In vitro evaluation of biofilm removal efficacy

[0338] General procedure for preparing biofilms

[0339] Preparation of saliva: Saliva was collected from healthy adults with no history of antibiotic use in the previous week and who did not require routine drug therapy. The analyst used a commercially available fluoride dentifrice and a soft-bristled toothbrush for routine oral hygiene for 3 days before beginning saliva collection. Saliva was collected at least 2 hours after the morning meal and centrifuged at 10,000 rpm for 20 minutes. The supernatant was poured into petri dishes and placed under UV for 45 minutes.

[0340]Preparation of bacteria: Bacteria (including Actinomyces naesei, Streptococcus oralis, Veillonella parvum, Lactobacillus casei and Fusobacterium nucleatum) were obtained from the artificial mouth consortium and individually cultured Streptococcus mutans was added thereto. Bacteria were grown in trypticase soy broth containing 6% sucros...

Embodiment 2

[0376] Example 2: Efficacy in Dissolving Early Morning Saliva Deposits

[0377] Several primary prototype formulations of the invention provided significant dissolution of morning salivary deposits. The saliva deposits were collected without evening and morning brushing, and the saliva supernatant was removed by decantation. Such saliva deposits contain appreciable amounts of plaque and leftover food debris that are difficult to dissolve and remove from the mouth without brushing with a dentifrice.

[0378] In this example, 4 mL of the prototype formulation or mouthwash containing cetylpyridinium chloride (CPC) was added to the saliva deposits and mixed for 1 minute at room temperature. Commercially available mouth rinses such as mouthwashes containing CPC showed no dissolution of morning salivary deposits. However, the formulations of the present invention were found to help dissolve saliva deposits.

[0379] In general, there was a correlation between those formulations o...

Embodiment 3

[0380] Example 3: Factors and Components Affecting % Biofilm Removal

[0381] Concentration of ionic liquid

[0382] It was found that increasing the amount of ionic liquid used in the formulation resulted in greater biofilm removal. The percent biofilm removal provided by each ionic liquid formulation was approximately about 60%. When two ionic liquids, choline salicylate and tris(2-hydroxyethyl)methylammonium methosulfate, were used simultaneously in the formulation, the percentage of biofilm efficacy was further increased to >70%.

[0383] Effect of different ingredients in the formulation

[0384] Experiments on the effect of different ingredients on the percentage of biofilm removal showed that the nature of the surfactant, the percentage of surfactant used and the amount of antimicrobial cetylpyridinium chloride (0~0.075%) did not affect the % biofilm removal .

[0385] The addition of glycerol, propylene glycol and / or sorbitol to the formulation increases the percen...

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PUM

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Abstract

An oral care composition is provided wherein the composition comprises an ionic liquid, wherein the ionic liquid comprises: a) a quaternary ammonium cation of the formula wherein R1, R2, R3 and R4 are each an organic moiety and may be the same or different, and at least one of R1, R2, R3 and R4 includes a hydroxyl; and b) an anion selected from the group consisting of salicylate, alkylsulfate, sulfate, acetate, halide, phosphate, alkyl phosphate and tosylate; wherein the oral care composition is a mouth rinse, toothpaste, toothpowder, oral bead or strip, fluid-encased dental strip, irrigation fluid, plaque removal liquid, dental floss, hard candy, soft candy, lozenge, chewing gum, or lollipop.

Description

Background technique [0001] Ionic liquids are a class of salts containing cations and anions that are liquid at temperatures below 100°C and generally have melting points below room temperature. Although not wishing to be bound by theory, ionic liquids generally have far less symmetry than ordinary salts, and the charges of cations and anions are distributed over a larger molecular volume by vibrations in the ionic liquid, which is thought to help make the They are liquid at much lower temperatures than common salts (eg NaCl, mp 801°C). Ionic liquids are generally composed of heterocyclic-containing cations and counter anions, and are generally inorganic in nature. The nature of the cations and anions determines the hydrophobicity, viscosity, density and other physical parameters and properties of the ionic liquid. [0002] Ionic liquids have been evaluated as environmentally friendly or "green" alternatives to common organic solvents for a wide range of organic synthesis ap...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/41A61Q11/00A61K31/14A61P1/02
CPCA61K8/416A61Q11/00A61K45/06A61K31/095A61K8/368A61K31/14A61K31/60A61K8/466A61P1/02A61K2300/00A61K8/4926A61K2800/30
Inventor M.佩特尔G.皮克特M.范德文M.哈桑R.帕雷德斯
Owner COLGATE PALMOLIVE CO
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