A traditional Chinese medicine prescription extract for whitening and freckle removal and its application

A whitening and freckle-removing and extract technology is applied in the field of traditional Chinese medicine, which can solve the problems of many adverse reactions, inconvenience of taking traditional Chinese medicine for a long time, and low cure rate, and achieves good application prospect and market prospect, fair and lustrous skin, and improved antioxidant capacity. Effect

Active Publication Date: 2018-04-27
黑龙江礼轩医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the traditional Chinese medicine treatment of chloasma still has the disadvantages of slow curative effect, low cure rate, long course of treatment, inconvenient long-term taking of traditional Chinese medicine, etc., which affects the compliance of treatment.
[0007] In a word, there are many medicines and methods for treating chloasma in traditional Chinese and western medicine, but either because the curative effect is too slow, or because of too many adverse reactions, there has not been a treatment plan that is effective, safe, recognized, and satisfactory to both doctors and patients. Very inconsistent with actual clinical needs

Method used

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  • A traditional Chinese medicine prescription extract for whitening and freckle removal and its application

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] The preparation of embodiment 1 TQW

[0043] Preparation:

[0044] 1. Accurately weigh the following traditional Chinese medicine raw materials: 4 parts of rootless vine, 4 parts of ancient mountain dragon, 2 parts of peach kernel, 2 parts of Shichangpu, 2 parts of red bean lingonberry, 2 parts of raspberry, 2 parts of Poria cocos, 2 parts of polygala, Polygonatum odoratum 1 part, 1 part ginseng.

[0045] 2. Mix and pulverize the ten kinds of medicinal materials in step 1, pass through No. 2 sieve of the Pharmacopoeia, and carry out supercritical carbon dioxide extraction of the medicinal powder, using ethanol as an entraining agent to obtain a brownish-yellow liquid. Among them, the extraction temperature is 30°C, the extraction pressure is 20MPa, the extraction time is 1h, the entrainer absolute ethanol dosage is 0.1ml / g powder, the analysis I pressure is 20MPa, the analysis temperature is 40°C, the analysis II pressure is 15MPa, the analysis The temperature is 30°C...

Embodiment 2

[0049] The preparation of embodiment 2 TQW

[0050] Preparation:

[0051] 1. Accurately weigh the following raw materials of traditional Chinese medicine: 5 parts of rootless vine, 5 parts of ancient mountain dragon, 3 parts of peach kernel, 3 parts of Shichangpu, 3 parts of red bean lingonberry, 3 parts of raspberry, 3 parts of Poria cocos, 3 parts of polygala, Polygonatum odoratum 2 parts, 1.5 parts of ginseng.

[0052] 2. Mix and pulverize the ten kinds of medicinal materials in step 1, pass through No. 2 sieve of the Pharmacopoeia, and carry out supercritical carbon dioxide extraction of the medicinal powder, using ethanol as an entraining agent to obtain a brownish-yellow liquid. Among them, the extraction temperature is 45°C, the extraction pressure is 40MPa, the extraction time is 2h, the entrainer absolute ethanol dosage is 0.5ml / g powder, the analysis I pressure is 15MPa, the analysis temperature is 25°C, the analysis II pressure is 10MPa, the analysis The temperatu...

Embodiment 3

[0056] The preparation of embodiment 3 TQW

[0057] Preparation:

[0058] 1. Accurately weigh the following raw materials of traditional Chinese medicine: 6 parts of rootless vine, 6 parts of ancient mountain dragon, 4 parts of peach kernel, 4 parts of Shichangpu, 4 parts of red bean lingonberry, 4 parts of raspberry, 4 parts of Poria cocos, 4 parts of polygala, Polygonatum odoratum 3 parts, 2 parts of ginseng.

[0059] 2. Mix and pulverize the ten kinds of medicinal materials in step 1, pass through No. 2 sieve of the Pharmacopoeia, and carry out supercritical carbon dioxide extraction of the medicinal powder, using ethanol as an entraining agent to obtain a brownish-yellow liquid. Among them, the extraction temperature is 60°C, the extraction pressure is 60MPa, the extraction time is 3h, the entrainer absolute ethanol dosage is 1ml / g powder, the analysis I pressure is 5MPa, the analysis temperature is 10°C, the analysis II pressure is 5MPa, the analysis temperature is 10°C...

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Abstract

The invention discloses a traditional Chinese medicine formula extract with the effect of whitening and removing spots. The traditional Chinese medicine formula extract of the present invention is based on ten kinds of traditional Chinese medicines, such as rootless vine, gushanlong, peach kernel, iris, red bean bilberry, raspberry, Poria, Polygala, Polygonatum, ginseng, etc. as raw materials, and adopts carbon dioxide supercritical extraction technology. And macroporous adsorption resin enrichment technology, extracted under certain process parameters. The extract has significant tyrosinase activity inhibitory effect and melanin production inhibitory effect, and the extract can be directly and safely applied to the preparation of pharmaceutical preparations, health products and cosmetics for whitening sputum.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, and relates to a traditional Chinese medicine prescription extract, in particular to a traditional Chinese medicine prescription extract for whitening and freckle removal. The invention also relates to the application of the above-mentioned traditional Chinese medicine extract in the preparation of whitening and freckle-removing pharmaceutical preparations, health care products and cosmetics. Background technique [0002] Heart of beauty in everyone. With the improvement of living standards, people's requirements for quality of life are getting higher and higher, and people pay more and more attention to the natural whitening of the skin, and the face is particularly important. Chloasma is a kind of acquired pigmentation skin disease, which is localized and irregular skin pigmentation changes caused by various reasons. The clinical manifestations are symmetrical pigmentation, butterf...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8969A61K8/9728A61K8/9789A61K8/9794A61P17/00A61Q19/02A61Q19/00A23L33/00
Inventor 李建民王业秋李孟张明磊陈晨王帅牟璐璐牛春影裴元元杨柳高海娜党文军张宁
Owner 黑龙江礼轩医药科技有限公司
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