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Traditional Chinese medicine composition for external use with soothing and anti-irritant effect and preparation method thereof

An anti-irritation and composition technology, applied in the field of external Chinese medicine composition, to achieve the effect of improving skin immunity and resistance, easy acquisition, and inhibiting cell DNA damage and leakage

Active Publication Date: 2018-04-03
SHANGHAI ZHONGYI DAILY CHEM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are also sensitizing risk substances in cosmetics

Method used

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  • Traditional Chinese medicine composition for external use with soothing and anti-irritant effect and preparation method thereof
  • Traditional Chinese medicine composition for external use with soothing and anti-irritant effect and preparation method thereof
  • Traditional Chinese medicine composition for external use with soothing and anti-irritant effect and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] The preparation of embodiment 1 this Chinese medicine composition

[0054] (1) After the following raw materials are pulverized, weigh and mix them according to the weight ratio;

[0055] Lingxiaohua 20g, melon root 10g, sand ginseng 5g, cactus 10g, sophora flavescens 1g, radix radix 1g, sweet tea 5g.

[0056] (2) Extract with 65% ethanol by volume, the g / mL mass-volume ratio of crude drug to ethanol is 1:15, and extract for 3 hours at 70°C;

[0057] (3) cooling the extract obtained in step (2) to room temperature 20° C., and filtering through 100 mesh to obtain the filtrate;

[0058] (4) The 1,3-butanediol of the original ethanol amount is added to the filtrate, and the 1,3-butanediol is miscible evenly, and the ethanol in the solution is evaporated by rotary evaporation, and a 1.2 μm filter plate is spread in a Buchner funnel, and the above-mentioned obtained filtrate is vacuum filtered and collected. The filtrate is ready.

Embodiment 2

[0059] The preparation of embodiment 2 this Chinese medicine composition

[0060] (1) After the following raw materials are pulverized, weigh and mix them according to the weight ratio;

[0061] Lingxiaohua 10g, melon root 5g, sand ginseng 1g, cactus 1g, sophora flavescens 10g, Ophiopogon japonicus 5g, sweet tea 10g.

[0062] (2) Extract with ethanol with a volume percentage of 95%, the mass volume ratio of the crude drug to ethanol (g / mL) is 1:30, and extract at 90°C for 1 hour;

[0063](3) cooling the extract obtained in step (2) to room temperature of 30° C., and filtering through 200 mesh to obtain the filtrate;

[0064] (4) The 1,3-butanediol of the original ethanol amount is added to the filtrate, and the 1,3-butanediol is miscible evenly, and the ethanol in the solution is evaporated by rotary evaporation, and a 1.2 μm filter plate is spread in a Buchner funnel, and the above-mentioned obtained filtrate is vacuum filtered and collected. The filtrate is ready.

Embodiment 3

[0065] Embodiment 3 The preparation of this Chinese medicine composition

[0066] (1) After the following raw materials are pulverized, weigh and mix them according to the weight ratio;

[0067] Lingxiaohua 1g, melon root 1g, sand ginseng 10g, cactus 15g, sophora flavescens 5g, radix radix 10g, sweet tea 1g.

[0068] (2) Extract with ethanol with a volume percentage of 50%, the mass volume ratio of the crude drug to ethanol (g / mL) is 1:10, and extract at 80°C for 4 hours;

[0069] (3) cooling the extract obtained in step (2) to room temperature (25° C.), and filtering through 200 mesh to obtain the filtrate;

[0070] (4) The 1,3-butanediol of the original ethanol amount is added to the filtrate, and the 1,3-butanediol is miscible evenly, and the ethanol in the solution is evaporated by rotary evaporation, and a 1.2 μm filter plate is spread in a Buchner funnel, and the above-mentioned obtained filtrate is vacuum filtered and collected. The filtrate is ready.

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Abstract

The invention discloses a traditional Chinese medicine composition for external use with the functions of relieving sensitivity, relieving itching and anti-irritation. The external-use traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 1-20 of Lingxiaohua, 1-10 of melon root, 1-10 of Radix Radix, 1-15 of Cactus, 1-10 of Sophora flavescens, 1-10 of Ophiopogon japonicus 10. Sweet tea 1-10. The invention has been proved by experiments that it can antagonize the irritation of surfactants and preservatives in cosmetics, has effective allergy inhibition and antipruritic effects, and has the effect of inhibiting type I hypersensitivity (immediate hypersensitivity) by reducing the content of IL-6 , inhibits type IV hypersensitivity (delayed type hypersensitivity) by reducing the content of IL-8. It also has whitening and moisturizing effects and acts as a skin barrier. The raw material of the invention is easy to obtain, the preparation method is simple, green and safe, easy to be accepted by allergic people, and has good application prospect and market prospect.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition for external use, in particular to a traditional Chinese medicine composition for external skin care with soothing and anti-irritant effects and a preparation method thereof. Background technique [0002] According to the domestic epidemiological survey, the incidence of allergic diseases in my country was as high as 37.3% in 2010, of which the skin sensitive population was about 3%, and it increased at a rate of 23 times every 10 years. Most consumers use skin care products to resist skin damage and stay away from allergies. However, there are also sensitizing risk substances in cosmetics. my country's national standard GB 17149.2-1997 "Diagnostic Criteria and Treatment Principles for Cosmetic Contact Dermatitis" issued in 1997 lists more than 130 common allergens of cosmetic contact dermatitis. Consumers are more concerned about the irritation and sensitivity caused by cosmetics th...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8968A61P17/00A61P37/08A61K8/9794A61K8/9789A61Q19/00A61Q19/02
Inventor 赵仕芝董义伟陈虎
Owner SHANGHAI ZHONGYI DAILY CHEM CO LTD
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