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Tandem quadrupole mass spectroscopy device

A mass analysis device, series quadrupole technology, applied in measurement devices, analytical materials, trajectory-stabilized spectrometers, etc., to achieve high sensitivity, ensure separation, and reduce the effect of intensity drop

Inactive Publication Date: 2015-07-08
SHIMADZU SEISAKUSHO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In addition, since the amplitude of the flight velocity of product ions is enlarged, the intensity of the peak top (Peak top) decreases significantly.

Method used

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Embodiment Construction

[0052] Hereinafter, an embodiment of the tandem quadrupole mass spectrometer according to the present invention will be described with reference to the drawings.

[0053] figure 1 It is a schematic configuration diagram of main parts of the tandem quadrupole mass spectrometer of the first embodiment.

[0054] In the tandem quadrupole mass spectrometer of this embodiment, the inside of the chamber 1 evacuated by a vacuum pump (not shown) is equipped with: an ion source 2 that ionizes compounds in the sample; A device (usually marked with Q1) 3, which uses ions having a specific mass-to-charge ratio as a precursor ion and selectively passes the precursor ion; a collision cell 4, dissociates the precursor ion inside it to generate each A product ion; the rear quadrupole mass filter (customarily marked with Q3) 6, which selectively passes ions with a specific mass-to-charge ratio in the product ion; detector 7, which detects the mass of the rear quadrupole Filter 6 ions. Inside...

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Abstract

A measurement condition storage unit (31) that is built into a control unit (30) stores a CID gas condition table (31a) that indicates the relationship between the scanning speed of mass scanning in a pre-stage quadrupole mass filter (3) and CID gas supply pressure. If the scanning speed is high, the impact of ion speed reduction due to collision with CID gas in a collision cell (4) becomes relatively large. Consequently, an appropriate CID gas supply pressure for each scanning speed is searched for beforehand and stored in the CID gas condition table (31a) so that the collapse of the waveform of the peak on a mass spectrum becomes small and ion strength becomes as high as possible. When measuring the target sample, if a precursor ion scan measurement mode or the like is designated, the CID gas supply pressure according to the scanning speed at the time is obtained on the basis of the CID gas condition table (31a), and a CID gas supply unit (8) is controlled. Thus, regardless of the scanning speed, a mass spectrum for which peak separability is high and sensitivity is good can be obtained.

Description

technical field [0001] The present invention relates to a kind of tandem system that dissociates ions with a specific mass-to-charge ratio m / z by collision-induced dissociation (CID=Collision-Induced Dissociation), and performs mass analysis on the resulting product ions (fragment ions). Quadrupole mass analyzer. Background technique [0002] MS / MS analysis (also referred to as tandem analysis) is well known as one method of mass analysis for identification of substances with large molecular weights and / or analysis of their structures. A relatively simple and inexpensive tandem quadrupole mass spectrometer (also referred to as a triple quadrupole mass spectrometer) is one of widely used mass spectrometers capable of performing MS / MS analysis. [0003] As disclosed in Patent Document 1, the tandem quadrupole mass spectrometer is common, with a collision cell (Collision cell) that dissociates ions, and a quadrupole mass filter (Quadrupole mass filter) before and after it. Th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/62H01J49/42
CPCH01J49/005H01J49/0031H01J49/4215
Inventor 藤田慎二郎
Owner SHIMADZU SEISAKUSHO LTD
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