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Medicine composition for treating climacteric osteoporosis and preparation method of medicine composition

A technology of osteoporosis and composition, which is applied in the field of pharmaceutical preparations, can solve the problems of treating the symptoms but not the root cause, dependence and side effects, and lack of calcitonin, and achieves a short course of treatment, no toxic side effects, and high efficiency. Effect

Inactive Publication Date: 2015-07-08
马祥海
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

(3) Calcitonin (CT) deficiency: after menopause, the level of CT decreases, which may contribute to the occurrence of osteoporosis due to the weakening of factors that inhibit bone resorption
(4) The role of other hormones: Some data show that patients with primary osteoporosis have abnormal secretion of thyroid hormones, glucocorticoids, growth hormones, life factors (especially growth interferon C), and gastrin, but Its etiological significance has not been elucidated
[0011] However, Western medicine treatment: the absorption of trace elements is uncertain, affects appetite, treats the symptoms but not the root cause, is not conducive to treatment, and often has dependence and side effects

Method used

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  • Medicine composition for treating climacteric osteoporosis and preparation method of medicine composition
  • Medicine composition for treating climacteric osteoporosis and preparation method of medicine composition

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Effect test

preparation example Construction

[0066] When the dosage form of the pharmaceutical composition is granules, the preparation method includes the following steps:

[0067] In the first step, the raw materials of the pharmaceutical composition are mixed according to the proportions, and ethanol with an alcohol concentration of 85%-95% is added 4-8 times the mixture, heated to boiling and refluxed for 3-5 hours, filtered, The percolation method is used to slowly percolate at a rate of 1 to 2 ml per minute, collect the percolate, and then concentrate it under reduced pressure under a vacuum of 0.06 to 0.09 Mpa to a paste with a relative density of 1.04 to 1.10 at 50 to 60°C. For spray drying, the inlet air temperature of the spray dryer is 160-175°C, and the outlet air temperature is 80-85°C, and then crushed into powder to make dry paste powder;

[0068] In the second step, 0.2-0.4 times of sucrose powder and 0.1-0.2 times of dextrin relative to the mass of dry paste powder are added to the obtained dry paste powder t...

Embodiment 1

[0077] Example 1 Granules

[0078] The preparation process of the granule of the present invention is: take 250g walnut kernel, 200g thousand-year health, 150g dried tangerine peel, 250g Ligustrum lucidum, 150g Eclipta prostrata 150g, 200g wild bean, 170g dog ridge, 300g Sargentodoxa cuneata, 450g Drynaria fortunei, Morinda officinalis 250g, Epimedium 150g, Curculio 30g, Concanavalina 150g, Geshanxiao 220g, Greenwood Fragrance 180g, Boxwood 260g, Turmeric 200g, Japonica Rice 240g, Thorn Berry 150g, Distracted Wood 220g, Wheat Chopsticks 350g , 140g of wild wheat tiller, 210g of wild thrips and 350g of wild fruit;

[0079] In the first step, the raw materials of the pharmaceutical composition are mixed according to the stated proportions, and ethanol with an alcohol concentration of 90% is added 7 times of the mixture, heated to boiling and refluxed for 4 hours, filtered, and diafiltration is used for every minute Slowly permeate at a speed of 1.5ml, collect the percolate, and then...

Embodiment 2

[0081] Example 2 Capsules

[0082] The preparation process of the capsule of the present invention is: 300g walnut kernel, 160g thousand-year health, 220g tangerine peel, 120g Ligustrum lucidum, 180g Eclipta prostrata, 300g wild bean, 150g dog ridge, 200g Sargentodoxa cuneata, 350g Drynaria fortunei, Morinda officinalis 400g, Epimedium 220g, Curculio 30g, Concanavalina 250g, Geshanxiao 170g, Greenwood Fragrance 150g, Boxwood 320g, Turmeric 150g, Japonica Rice 330g, Thorn Berries 210g, Distracted Wood 300g, Wheat Chopsticks 450g , 120g of wild wheat tiller, 280g of thylacineae and 310g of wild berries;

[0083] In the first step, the raw materials of the pharmaceutical composition are mixed in proportion, and ethanol with an alcohol concentration of 85% relative to the mass of the mixture is added, heated to reflux for 3 hours, extracted and filtered to obtain the first extract; The medicine residue is added with ethanol with an alcohol concentration of 90% which is twice the mass ...

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Abstract

The invention discloses a medicine composition for treating climacteric osteoporosis and a preparation method of the medicine composition. The medicine composition comprises the various bulk drugs: English walnut seeds, rhizoma homalonemae, pericarpium citri reticulatae, glossy privet fruit, eclipta, wild groundnut seeds, rhizoma cibotii, sargentgloryvine stems, rhizoma drynariae, radix morindae officinalis, herba epimedii, rhizoma curculiginis, sword bean, auriculate swallowwort roots, dutchmanspipe roots, boxwood, turmeric, polished round-grained rice, dahurian rose fruit, diaphragma juglandis, common mappianthus stems, fruit of highland barley malt, seeds of field pennycress, sieve sedge, oldham fissistigma roots, wideleaf osbeckia roots, wild water-chestnut fruit and sheathstipe greenbrier tubers and roots. The medicine composition has the beneficial effects that the medicine composition has the efficacies of tonifying qi, nourishing blood, regulating qi, strengthening a spleen, and warming and recuperating the kidney-yang, as well as the effects of building bones and muscles, tonifying a liver and a kidney, strengthening bone and alleviating pain, and has the advantages that the medicine composition takes effect rapidly, is high in efficiency, definite in treatment effect, short in treatment course and low in cost, and has no toxic or side effect.

Description

Technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a pharmaceutical composition for treating menopausal osteoporosis and a preparation method thereof. Background technique [0002] Osteoporosis is a group of bone diseases caused by multiple reasons. The bone tissue has normal calcification, the calcium salt and the matrix are in a normal ratio, and the metabolic bone disease is characterized by a decrease in the amount of bone tissue per unit volume. In most osteoporosis, the reduction of bone tissue is mainly due to increased bone resorption. The onset is usually slow and individual is quicker. The biochemical examination is basically normal, characterized by bone pain and easy fracture. Pathological anatomy showed that the cortical bone was thin, and the trabecula was sparse and atrophied and the osteoid layer was not thick. Osteoporosis, primary osteoporosis is a systemic bone disease characterized by decrease...

Claims

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Application Information

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IPC IPC(8): A61K36/9066A61P19/10A61P15/00
Inventor 马祥海
Owner 马祥海
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