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SCOS (Sertoli cell only syndrome) mouse modeling prejudging method based on Raman spectrum

A technology of Raman spectroscopy and mice, applied in the computer field, can solve problems such as low reliability, long time-consuming, and complicated operation process, and achieve the effect of high reliability, short time-consuming, and simple operation process

Inactive Publication Date: 2015-06-24
GUANGXI UNIVERSITY OF TECHNOLOGY
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Problems solved by technology

[0005] In the process of realizing the present invention, the inventor found that there are at least defects such as complicated operation process, long time-consuming and low reliability in the prior art

Method used

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Embodiment Construction

[0039] Preferred embodiments of the present invention are described below, and it should be understood that the preferred embodiments described here are only used to illustrate and explain the present invention, and are not intended to limit the present invention.

[0040] According to an embodiment of the present invention, a Raman spectrum-based predictive method for modeling of SCOS mice is provided.

[0041] In the technical solution of the present invention, the prediction process of seminiferous tubules in the SCOS mouse model is divided into 4 steps using Raman spectroscopy:

[0042] 1. Obtain Raman spectral characteristics of mouse samples

[0043] 1.1 Inject busulfan in a larger dose, feed mice, and feed a group of untreated normal mice as control samples;

[0044] 1.2 After injecting busulfan and feeding for four weeks, the mice were sacrificed and the testes were removed;

[0045] 1.3 Fixing, sectioning and staining the testis;

[0046] 1.4 The seminiferous tubu...

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Abstract

The invention discloses an SCOS mouse modeling prejudging method based on Raman spectrum, comprising the following steps: a, obtaining mouse sample Raman spectrum feature; b, obtaining Raman spectrum seminiferous tubule spectral peak vector sample database based on the obtained mouse sample Raman spectrum feature; c, obtaining seminiferous tubule Raman spectrum based on the obtained Raman spectrum seminiferous tubule spectral peak vector sample database; d, extracting feature spectral peak based on the obtained seminiferous tubule Raman spectrum; and e, detecting the seminiferous tubule based on the extracted feature spectral peak. The SCOS mouse modeling prejudging method based on Raman spectrum, provided by the invention, can overcome the defects in the prior art, such as complex operation process, long consumed time and low reliability, so as to realize the advantages of simple operation process, short consumed time and high reliability.

Description

technical field [0001] The invention relates to the field of computer technology, in particular to a Raman spectrum-based predictive method for modeling of SCOS mice. Background technique [0002] Male infertility has always been a medical problem plaguing the world, and it has strong social significance. Male infertility is a complex clinical syndrome caused by many factors, among which azoospermia is one of the common causes of male infertility, and Sertoli cell only syndrome (SCOS) is the most serious of azoospermia. a type of pathology. [0003] Busulfan is a classic chemotherapy drug that can induce transient apoptosis of spermatogonia, which can lead to SCOS in severe cases. The mouse SCOS model treated with busulfan is the most classic animal model of azoospermia. Individual differences in mice, busulfan injection dose and other factors can affect the modeling rate of this model. On the other hand, in animal experiments, in order to study the pathogenesis of SCOS,...

Claims

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Application Information

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IPC IPC(8): G01N21/65
Inventor 石玉秋刘宇飞卢慧胡波
Owner GUANGXI UNIVERSITY OF TECHNOLOGY
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