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Medicine for preventing and treating acute altitude stress

A technology of altitude sickness and drugs, applied in the direction of drug combinations, pharmaceutical formulas, organic active ingredients, etc., can solve problems such as instability, slow action, and poor efficacy of clinical reactions, and achieve the effect of preventing and treating acute hypertensive reactions

Inactive Publication Date: 2015-06-24
中国人民解放军西藏军区总医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Rhodiola capsules are used to prevent and treat acute altitude sickness. The course of taking it lasts up to a week, the effect is slow and unstable, and the clinical response is not effective.

Method used

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  • Medicine for preventing and treating acute altitude stress
  • Medicine for preventing and treating acute altitude stress

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0023] Such as figure 1 Shown, the present invention provides and comprises a kind of production preparation method of Gaoyuankang capsule, comprises the following steps:

[0024] Step 1, prepare the first mixture of A part of dexamethasone sodium phosphate and B part of diazepam:

[0025] Add B parts of diazepam in M ​​times, wherein the amount of diazepam added for the ith time is 2 i-1 A, the amount of diazepam left after the i-th time is C i =B-∑2 i-1 A, i≥1;

[0026] After completing the mth time, when , the amount of diazepam added for the m+1th time is 2 m A, the amount of diazepam added for the m+2th time is C m -2 m A, then the preparation is completed, M=m+2; when , the amount of diazepam added for the m+1th time is C m , then the preparation is completed, M=m+1; add diazepam each time and mix evenly before proceeding to the next time;

[0027] A+B=D;

[0028] Step 2, utilize the first mixture, aminophylline and starch to prepare E part of the second mix...

preparation Embodiment 1

[0045] Take 7.5g of dexamethasone sodium phosphate, mix with 7.5g of diazepam, then add 17.5g of diazepam and mix evenly.

[0046] Then add 33g of starch and aminophylline (1 / 2 each of starch and aminophylline) and mix well, leave 50g of starch for later use, then add 66g, 132g, 264g, 528g, 1094g of starch and aminophylline (each time The starch and aminophylline respectively account for 1 / 2) and mix well to obtain the second mixture. Strictly speaking, the sum of aminophylline and starch added for the first time should be 32.5g, which should be adjusted appropriately here; the last one should be 1056g, which should also be slightly adjusted.

[0047] Put the second mixture into the mixer and mix for 10 minutes, pour out the material and put it into the granulator, pour the 50g of starch left before into the water and heat it to make 10% starch slurry, and pour the starch slurry into the granulator for granulation , to obtain the first granule, put the first granule into an o...

preparation Embodiment 2

[0055] Take 10g of dexamethasone sodium phosphate, mix with 10g of diazepam, then add 20g of diazepam and mix evenly.

[0056] Then add 40g of starch and aminophylline (1 / 2 each of starch and aminophylline) and mix well, keep 45g of starch for use (for granulation), then add 80g, 160g, 320g, 640g, 915g of starch and ammonia in sequence Theophylline (each added starch and aminophylline each account for 1 / 2) was mixed to obtain the second mixture.

[0057] Put the second mixture into the mixer and mix for 12 minutes, pour out the material and put it into the granulator, pour the 45g of starch left before into the water and heat to make 10% starch slurry, and pour the starch slurry into the granulator for granulation , to obtain the first granule, put the first granule into an oven and bake at 50°C for 24 hours, take it out, use a granulator to sizing, and get the second granule after finishing the granulation, and fill the second granule with a capsule machine to get the finishe...

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Abstract

The invention discloses a medicine for preventing and treating acute altitude stress. The medicine comprises the following raw materials in percentage by mass: 0.23-1.15 percent of dexamethasone sodium phosphate, 1.14-5.68 percent of diazepam, 45.45-48.41 percent of aminophylline and a pharmaceutically acceptable excipient. Since capsules for treating acute altitude stress comprise 0.23-1.15 percent of dexamethasone sodium phosphate, 1.14-5.68 percent of diazepam and 45.45-48.41 percent of aminophylline, acute altitude stress can be treated effectively, the effective rate of treatment can be above 87%, and the maximum effective rate of treatment is up to 92.5%.

Description

technical field [0001] The invention relates to a medicine production method, in particular to a medicine for preventing and treating acute altitude sickness. Background technique [0002] For acute altitude sickness, there is no effective prevention and treatment drug on the market. Rhodiola capsules were used to prevent and treat acute altitude sickness. The course of taking it lasted for a week, the effect was slow and unstable, and the clinical response was not effective. Contents of the invention [0003] In view of the above technical problems, the present invention provides a medicine for preventing and treating acute altitude sickness, which is effective in treating acute altitude sickness, and has stable and long-lasting effects. [0004] The technical scheme provided by the invention is: [0005] A medicine for preventing and treating acute altitude sickness, comprising 0.23-1.15% dexamethasone sodium phosphate, 1.14-5.68% diazepam, 45.45-48.41% aminophylline a...

Claims

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Application Information

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IPC IPC(8): A61K31/661A61P39/00A61K31/5513A61K31/522
Inventor 李素芝王建军缪士平陶朝阳孙创斌蒋海军
Owner 中国人民解放军西藏军区总医院
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