Method for predicting sensitivity of cervical cancer patient subjected to paclitaxel and cis-platinum adopted chemotherapy

Abstract

A method for predicting sensitivity of a cervical cancer patient subjected to paclitaxel and cis-platinum adopted chemotherapy comprises the steps: S1, preopreative examination is performed; S2, nidus analysis is performed; S3, mathematical statistics is performed; S4 sensitivity judgment is performed, namely serum SCC-Ag level analysis and post-chemotherapy MRI measurement are performed to judge chemotherapy sensitivity so as to determine whether a drug resistance rule is subjected to a postoperative pathological measurement result or not, it is confirmed that the patient is drug-sensitive if the drug resistance rule is subjected to the postoperative pathological measurement result, and it is confirmed that the patient is drug-resistant if the drug resistance rule is not subjected to the postoperative pathological measurement result. An experimental result of drug resistance analysis performed by means of the method for predicting the sensitivity of the cervical cancer patient subjected to the paclitaxel and cis-platinum adopted chemotherapy shows that change of the serum SCC-Ag level has close relationship with the sensitivity of cervical squamous cell neoadjuvant chemotherapy, important information can be provided for judgment on drug resistance of the patient, SCC-Ag and magnetic resonance imaging can be jointly and clinically utilized to assess the chemotherapy sensitivity, and the prediction accuracy is obviously higher than the prediction accuracy of an MRI imageology method widely and clinically used at present.

Description

technical field [0001] The invention relates to the field of medical technology, and more specifically relates to a method for predicting chemotherapy sensitivity of cervical cancer patients using paclitaxel and cisplatin. Background technique [0002] Due to the large size of the tumor, locally advanced cervical cancer brings certain difficulties to surgery, and the incidence of intraoperative bleeding and surgical complications is high. Simple surgery or radiotherapy is not easy to control, prone to lymph node metastasis or distant metastasis, and the five-year survival rate Low. [0003] Recently, neoadjuvant chemotherapy (NACT) has been considered as a new and promising treatment for locally advanced (stage Ib-IIb) cervical cancer. The results of the study showed that for patients with the same tumor clinical stage, preoperative neoadjuvant chemotherapy was more likely to shrink the tumor than simple radical surgery, and could reduce intraoperative bleeding and complica...

AI Technical Summary

Problems solved by technology

[0005] The main problem with NACT treatment at present is that it is difficult to accurately reflect the effect of treatment by imaging after premenstrual chemotherapy. The reason is that cervical lesions may undergo degeneration, necrosis, and fibrosis after premenstrual chemotherapy, resulting in mixed signals of the cervix. , it is difficult to distinguish on conventional MRI plain scan images, resulting in large deviations in the evaluation results

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