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Bioactive bone repair material containing williams elder twig as well as preparation method and application thereof

A biologically active, elderberry technology, applied in the direction of additive processing, medical science, prosthesis, etc., can solve the problems of uncontrollable shape and internal structure, lack of osteoinductive activity and shape, etc., achieve excellent biocompatibility, promote Osteogenesis, slowing down effect

Inactive Publication Date: 2015-06-10
STOMATOLOGY AFFILIATED STOMATOLOGY HOSPITAL OF GUANGZHOU MEDICAL UNIV
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  • Description
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  • Application Information

AI Technical Summary

Problems solved by technology

Its main disadvantages are the lack of osteoinductive activity and shape, and its shape and internal structure cannot be controlled by traditional methods

Method used

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] A preparation method of a bioactive bone repair material containing elderberry, comprising the following steps:

[0027] 1) Add 4g of PLGA and 2g of TCP into 40ml of 1,4-dioxane, dissolve and stir for 24 hours;

[0028] 2) Add 2mg–0.4g of the active ingredient of elderberry into 10ml of 1,4-dioxane for dissolution, then add 1ml of the elderberry solution into the solution obtained in step 1), and stir for another 2 hours to obtain The slurry of PLGA / TCP / sambucus is to obtain the bioactive bone repair material containing elderberry.

[0029] The PLGA described in step 1) has a molecular weight of 100,000, and the molar ratio of lactic acid to glycolic acid is 70:30, purchased from Shandong Institute of Medical Devices.

[0030] The elderberry active ingredient described in step 2) is provided by Jinan University School of Pharmacy. The extraction method of the elderberry active ingredient is as follows, the elderberry stems and branches are extracted with 60% ethanol, ...

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Abstract

The invention discloses a bioactive bone repair material containing williams elder twig as well as a preparation method and application thereof, and belongs to the field of bone repair materials. The preparation method of the bioactive bone repair material containing williams elder twig comprises the following steps: adding 4g of PLGA and 2g of TCP into 40ml of 1,4-dioxane, and dissolving and stirring for 24 hours; and adding 2mg to 0.4g of williams elder twig active components into 10ml of 1,4-dioxane, dissolving, then adding 1ml of a williams elder twig dissolved solution into an obtained solution, and then stirring for 2 hours to obtain the bioactive bone repair material containing williams elder twig. The bioactive bone repair material containing williams elder twig, disclosed by the invention, can be subjected to three-dimensional printing to form an artificial bone by virtue of a low-temperature fused deposition production and molding technology; and an obtained artificial bone material can be used for releasing an estrogen-like traditional Chinese medicine namely williams elder twig in an absorption process, and can be used for slowing down the bone loss rate of patients suffering osteoporosis; and meanwhile, the bioactive bone repair material containing williams elder twig has biocompatibility and bone inducing ability.

Description

technical field [0001] The invention belongs to the field of bone repair materials, in particular to a biologically active bone repair material containing elderberry and its preparation method and application. Background technique [0002] The treatment of bone defects and related diseases has always been a challenge in the field of medicine. Bone defects can be divided into lacunar and segmental bone defects according to the shape and location of the defect. At present, for the repair of bone defects, the lacunar defect is mainly carried out by filling, and the bone defect is repaired by using the conduction of the surrounding bone. For segmental defects, it is generally necessary to implant block bone repair materials. [0003] There are three types of bone defect repair materials: autologous bone, allogeneic bone, and artificial bone. Among them, autologous bone has the advantages of osteotransmission, osteogenesis, and osteoinduction, and has become the current gold st...

Claims

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Application Information

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IPC IPC(8): A61L27/46A61L27/54A61L27/56B29C67/00B33Y10/00
Inventor 周苗
Owner STOMATOLOGY AFFILIATED STOMATOLOGY HOSPITAL OF GUANGZHOU MEDICAL UNIV
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