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Method for synthesizing hollow molecularly imprinted polymer through silicon dioxide matrix sacrifice method

A silica, molecular imprinting technology, applied in chemical instruments and methods, other chemical processes, etc., can solve problems such as imprecision

Inactive Publication Date: 2015-06-03
甘肃省产品质量监督检验中心
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AI Technical Summary

Problems solved by technology

[0004] The current detection methods cannot accurately determine and detect the residues of fluoroquinolones (FQs) synthetic antibiotics in animal-derived foods. For the sake of people's health, it is urgent to find a scientific method for qualitative and quantitative fluoroquinolones (FQs)

Method used

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Embodiment Construction

[0007] Step 1. Synthesis of silica microspheres: Dissolve 0.92mL (860mg) tetraethoxysilane (TEOS) in 54mL absolute ethanol, slowly add 1.00mL concentrated ammonia water (NH3 concentration 25%-28%) dropwise, Then add 1.00mL ultrapure water, keep the stirring speed at 250rpm, stir at room temperature for 4 hours, let it stand still, centrifuge at 15000rpm three times to remove unreacted substances in the supernatant, collect the precipitate and redisperse it in ethanol, centrifuge at 4000rpm to remove large particles, and leave supernatant to obtain uniformly dispersed silica microspheres for subsequent use;

[0008] Step 2 Surface polymerization Weigh 1.0 g of the silica microspheres obtained in Step 1, disperse them in absolute ethanol, add 0.50 mL of 3-(methacryloyl chloride)propyltrimethoxysilane (MATMS), stir at room temperature for 24 hours, and centrifuge Discard the unreacted silane coupling agent (recorded as SiO2MATMS), and dry to constant weight;

[0009] Step 3 Accu...

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PUM

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Abstract

The invention discloses a method for synthesizing hollow molecularly imprinted polymer through a silicon dioxide matrix sacrifice method, belonging to the technical field of analysis and detection. In order to find a way of scientifically and accurately detecting and quantifying excessive residues of FQs (Fluoroquinolones) on animal derived food such as farm animals, fowls and aquatic animals, the silicon dioxide matrix sacrifice method is adopted for synthesizing the hollow molecularly imprinted polymer, namely, a silica gel template sacrifice method is adopted, the hollow material with high mass transfer kinetics, high selectivity and high appetency is synthesized as an adsorbent to enrich and selectively separating FQs drugs, and a very good effect is obtained by combining the method with HPLC-UV detection.

Description

technical field [0001] The invention belongs to the technical field of molecularly imprinted polymer synthesis in the technical field of pesticide molecularly imprinted. Background technique [0002] Molecular imprinting technology (MIT) is a method to prepare molecularly imprinted polymers (MIPs) with specific selectivity for target molecules and special bonding sites. The polymer formed by the traditional method of synthesizing MIP must go through operational steps such as grinding and sieving, and the formed material has uneven pore size and irregular shape. This leads to disadvantages such as poor mass transfer kinetics and low adsorption capacity, which are not suitable for the application as an adsorbent. [0003] Fluoroquinolones (FQs) are a kind of synthetic antibiotic drugs, which are widely used in the prevention and treatment of bacterial infectious diseases in livestock, poultry and aquatic animals. Its main function is to destroy the metabolism and reproduction...

Claims

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Application Information

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IPC IPC(8): C08F222/14C08F220/06C08F2/44C08K9/06C08K3/36C08J9/26B01J20/26B01J20/30
Inventor 周春红汤万进张海霞
Owner 甘肃省产品质量监督检验中心
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