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Use of beta-1,3 (4)-endoglucanohydrolase, beta-1,3 (4) glucan, diatomaceous earth, mineral clay and glucomannan to augment immune function

a technology of endoglucanohydrolase and glucan, which is applied in the field of augmentation of immune function, can solve the problems of reducing individuals' ability to fight diseases, and achieve the effects of reducing colonization by pathogens, enhancing immune function, and minimizing or eliminating invasion of blood compartments

Inactive Publication Date: 2005-10-06
OMNIGEN RES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

"The present invention provides a novel method for enhancing the immune system of mammalian and avian species to reduce susceptibility to fungal and bacterial diseases. The invention involves a combination of β-1,3 (4)-endoglucanohydrolase, β-glucan, diatomaceous earth, mineral clay, and glucomannan. The invention increases expression of neutrophil L-selectin and interleukin-1β to minimize or eliminate colonization of epithelial surfaces and underlying parenchymal tissues by pathogenic fungi and bacteria, reduce populations of pathogenic organisms in blood, and minimize or eliminate pathologies caused by this colonization. The invention can be used as a prophylactic, an additive to feeds or foods infected with pathogenic fungi or bacteria, or a preferred method to treat and minimize or eliminate an existing, diagnosed or non-diagnosed, fungal or bacterial infection. The invention also minimizes or eliminates manifestations associated with the presence of pathogenic fungal and bacterial organisms in food or feed of mammalian and avian species."

Problems solved by technology

Stress reduces individuals' abilities to fight disease.
This may result in an infection (FIG. 6).

Method used

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  • Use of beta-1,3 (4)-endoglucanohydrolase, beta-1,3 (4) glucan, diatomaceous earth, mineral clay and glucomannan to augment immune function
  • Use of beta-1,3 (4)-endoglucanohydrolase, beta-1,3 (4) glucan, diatomaceous earth, mineral clay and glucomannan to augment immune function
  • Use of beta-1,3 (4)-endoglucanohydrolase, beta-1,3 (4) glucan, diatomaceous earth, mineral clay and glucomannan to augment immune function

Examples

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example 1

[0056] An experiment was conducted using 60 growing male and female sheep. Sheep were allocated to one of the five treatments (seven females and five males per treatment): [0057] 1. Control. [0058] 2. Immunosuppressed (daily injections of Azium [Dexamethasone], 0.1 mg / kg twice / day). [0059] 3. Immunosuppressed plus the invention fed at 0.5% of daily dry matter intake. [0060] 4. Immunosuppressed plus moldy feed (addition of Aspergillus fumigatus-infected wheat mill run; 1.5 lbs / head / day). [0061] 5. Immunosuppressed plus moldy feed (as in Treatment 4) plus the invention as outlined in Treatment 3.

[0062] Animals were fed a dairy-type diet for a period of 28 days. Immunosuppression was mediated in Treatments 2, 3, 4 and 5 by daily injection of Azium using a high dose (a model of extreme stress: Weber et al., 2001). Sheep on Treatments 4 and 5 were challenged with a pathogenic mold by feeding wheat mill run which had been contaminated with a pathogenic mold (Aspergillus fumigatus). Sheep...

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Abstract

A method for the augmentation of immune function is described. The invention comprises a combination of β-1,3 (4)-endoglucanohydrolase, β-1,3 (4)glucan, diatomaceous earth, mineral clay and glucomannan, which is fed to or consumed by mammalian or avian species in amounts sufficient to augment immune function. The invention described may be admixed with feeds or foods, incorporated into pelleted feeds or foods or administered orally to mammalian and avian species.

Description

REFERENCES CITED [REFERENCED BY][0001]4,857,512Aug. 15, 1989Wagner et al.514 / 545,183,667Feb. 2, 1993Koch, H.424 / 4745,519,009Oct. 1, 1993Donzis, B.514 / 546,395,311May 28, 2002Jia, Q.424 / 7446,541,678Apr. 1, 2003Klein, B.602 / 416,573,245Jun. 3, 2003Marciani, J.514 / 256,660,722Dec. 9, 2003Yvin, J. C.514 / 54OTHER REFERENCES [0002] Adib Conquy, M., C. Fitting. Immunological status of cardiac arrest and resuscitated patients.http: / / www.pasteur.fr / recherche / RAR / RAR2002 / Cytoinf-en.html, 2002. [0003] AOAC. 2002. Official Methods of Analysis. 17th Edition. AOAC International Press. [0004] Burton, J. L., R. J. Erskine. Immunity and mastitis. Some new ideas for an old disease. Vet. Clin. Food Anim. 19:1-45, 2003. [0005] Invivogen. http: / / www.invivogen.com / genedescription / TLR01.htm, 2004. [0006] Travis, J. Biologists reveal the proteins that first see dangerous microbes. Week of Sep. 8, 2001 Vol. 160, No. 10 [0007] Werling D., J. C. Hope, C. J. Howard, T. W. Jungi. Differential production of cytokine...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A23L29/00A23L29/294A61K31/716A61K31/736A61K33/06A61K35/02A61K38/47
CPCA61K31/716A61K31/736A61K35/02A23K20/00A23K20/163A23K20/189A23K20/20A23K20/28A23L29/015A23L29/03A23L29/06A23L29/294A23L33/10A23L33/16A23K50/10A23K50/75A61K38/46A23V2200/324A23V2250/15A23V2250/156A23V2250/5034A23V2250/5058C12Y302/01006A61K31/715A61K33/00A61K33/06A61K38/47A61P37/04A61K2300/00
Inventor PUNTENNEY, STEVENFORSBERG, NEIL
Owner OMNIGEN RES
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