Chitosan quaternary ammonium salt derivatives with good water solubility and antibacterial activity and preparation method of chitosan quaternary ammonium salt derivatives

Abstract

The invention relates to five chitosan quaternary ammonium salt derivatives with good water solubility and antibacterial activity and a preparation method of the chitosan quaternary ammonium salt derivatives, and belongs to the technical fields of chitosan antibacterial materials and preparation methods thereof. The preparation method comprises the following steps: reacting mono monosulfate ester of N-methyl-N-long-chain alkyl-N,N-2-hydroxyethyl ammonium halide with amino-protected N-benzylidene-chitosan, and carrying out amino deprotection reaction to obtain an O-quaternary ammonium salt-chitosan derivative. The five chitosan quaternary ammonium salt derivatives are simple in synthesis, high in substitution degree, low in cost, and stable in property, and has good water solubility and antibacterial activity and low cytotoxicity; and the purification method is simple and convenient; and the five chitosan quaternary ammonium salt derivatives provided by the invention have relatively good antibacterial capability on kinds of germs such as such as staphylococcus aureus and escherichia coli and various fungi such as aspergillus niger, are suitable for serving as antibacterial materials, medicine carriers and medical equipment materials, and have good application prospects.

Description

Technical field [0001] The invention relates to five chitosan quaternary ammonium salt derivatives with good water solubility and antibacterial activity and preparation methods thereof, and belongs to the technical field of chitosan antibacterial materials and preparation methods thereof. Background technique [0002] Chitosan (Chitosan, CS) is a product of chitin N-deacetylation, and it is also the only alkaline polysaccharide that occurs naturally. Due to different extraction methods, the relative molecular weight ranges from thousands to millions, so the water solubility is relatively poor. [1] . In the pharmaceutical industry, although chitosan has a wide range of uses, it is limited by its poor solubility and its application is greatly affected. Therefore, the chemical structure of chitosan is modified to improve its physical and chemical properties, especially its solubility. important. The structural modification of chitosan mainly modifies the amino and hydroxyl groups ...

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Problems solved by technology

According to literature reports [11-13] , the method of quaternization modification on chitosan-OH is mainly to use epoxy-based quaternary ammonium salt intermediates to react with amino-protected chitosan to obtain O-quaternized chitosan Derivatives, but the physical and chemical properties of the epoxy-based quaternary ammonium salt intermediate are unstable, and it is easy to absorb moisture, deliquify, and be deactivated by hydrolysis, so it must be prepared and used immediately, and its application is limited

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