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Traditional Chinese medicine composition used in three-dimensional conformal and intensity modulated radiation therapy for treating locally advanced pancreatic carcinomas

A technology of three-dimensional conformal and intensity-modulated radiotherapy, which is applied in pain-relieving pharmaceutical compositions and in the field of sensitization of three-dimensional conformal intensity-modulated radiotherapy for locally advanced pancreatic cancer. In order to improve radiosensitivity, relieve pain and inhibit proliferation

Active Publication Date: 2015-06-03
QINGDAO TUMOR HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The resection rate of pancreatic cancer and the curative effect of surgical treatment are extremely low, and there is no effective solution for surgical treatment in the short term, so doctors and patients place greater hope on other treatment methods other than surgery

Method used

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  • Traditional Chinese medicine composition used in three-dimensional conformal and intensity modulated radiation therapy for treating locally advanced pancreatic carcinomas
  • Traditional Chinese medicine composition used in three-dimensional conformal and intensity modulated radiation therapy for treating locally advanced pancreatic carcinomas

Examples

Experimental program
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Effect test

Embodiment 1

[0020] Sensitizing and pain-reducing effects of compound Kushen injection and Qingyi Huajifang granule administered in advance on three-dimensional conformal intensity-modulated radiotherapy for advanced pancreatic cancer.

[0021] Forty patients with advanced pancreatic cancer were selected, including 30 males and 10 females, with an average age of 59.6 years. According to the clinical stage of the International Union Against Cancer (UTCC): 12 cases of stage III and 28 cases of stage IV. There were 32 cases of pancreatic head cancer, 6 cases of pancreatic body cancer, and 2 cases of pancreatic tail cancer. Expected survival time > 3 months, electrocardiogram, liver and kidney function and blood routine are basically normal. Clinical symptoms include pain, loss of appetite, and weight loss. All patients have pain in various degrees, according to the chief complaint pain rating system (VRS) is divided into: 0 grade abdominal pain does not have, 1 grade abdominal pain 8 cases, ...

Embodiment 2

[0029] Sensitizing and pain-reducing effects of compound Kushen injection and Qingyi Huajifang granule on three-dimensional conformal intensity-modulated radiotherapy for advanced pancreatic cancer.

[0030] A total of 40 patients with advanced pancreatic cancer were selected, including 28 males and 12 females, with an average age of 62.2 years. According to the clinical stage of the International Union Against Cancer (UTCC): 14 cases of stage III and 26 cases of stage IV. There were 28 cases of cancer of the head of the pancreas, 7 cases of cancer of the body of the pancreas, and 5 cases of cancer of the tail of the pancreas. Expected survival time > 3 months, electrocardiogram, liver and kidney function and blood routine are basically normal. Clinical symptoms include pain, loss of appetite, and weight loss. All patients have pain in various degrees, according to the chief complaint pain rating system (VRS) is divided into: 0 grade abdominal pain without, 1 grade abdominal ...

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Abstract

The invention provides a traditional Chinese medicine composition and an application thereof in preparation of medicines which are used in three-dimensional conformal and intensity modulated radiation therapy for treating advanced pancreatic carcinomas and have synergistic sensitizing and pain relieving effects. The traditional Chinese medicine composition comprises compound Danshen root injection and Qingyi Huaji formula granules. The radiosensitivity of pancreatic carcinomas can be obviously improved, the proliferation inhibition effects on pancreatic carcinomas can be improved and the pains of patients can be relieved by applying the traditional Chinese medicine composition seven days before radiation therapy or while radiation therapy.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition and an application thereof, in particular to a pharmaceutical composition which can be used for three-dimensional conformal intensity-modulated radiotherapy sensitization and pain relief for locally advanced pancreatic cancer. Background technique [0002] Located in the upper abdomen, the pancreas is an important retroperitoneal organ, surrounded by important organs such as the stomach, duodenum, liver, spleen, and kidney. Pancreatic cancer, mainly refers to malignant tumors of the exocrine pancreas, is one of the common malignant tumors of the digestive system. In recent years, the incidence and mortality of pancreatic cancer have been on the rise in both developed and developing countries. The onset of pancreatic cancer is insidious, and there are few specific symptoms and signs. Only 10% of pancreatic cancer patients have the opportunity of surgical resection when they are diagnos...

Claims

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Application Information

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IPC IPC(8): A61K36/9064A61K36/896A61K9/08A61K9/16A61P35/00A61P29/00
Inventor 程君
Owner QINGDAO TUMOR HOSPITAL
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