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Traditional Chinese medicinal preparation for treating acute upper respiratory infection and preparation method of traditional Chinese medicinal preparation

A technology for the upper respiratory tract and traditional Chinese medicine preparations, which is applied in the direction of medical formulas, respiratory diseases, and medical preparations containing active ingredients, etc. It can solve the problems of inappropriate use of granules, reduced drug efficacy, and drug restrictions, and achieve the reduction of the dosage of excipients , Guaranteed clinical efficacy and high drug stability

Inactive Publication Date: 2015-06-03
GUANGXI DOUBLE ANT PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] The granules prepared by the traditional preparation method are used as forming aids, which have the following disadvantages: (1) the sucrose content is high, easy to deliquesce, soften and deteriorate, not suitable for long-term storage, and the stability of the drug is not good, which may easily cause the drug to enter the human body. (2) Since sucrose has strong biological activity, it can cause gastritis, obesity, diabetes and dental caries in children, so granules are not suitable for diabetes and other contraindicated drugs. Diabetic patients restrict the medication of many children, elderly and sugar-free patients; (3) The dosage is large (10-20g at a time), and the quality standards are recorded in the "Ministry of Health Drug Standards" Traditional Chinese Medicine Prescriptions Volume 10 P115 , due to the early drafting of the adopted standards, the specificity of some inspection items is poor, and it is far from meeting the current requirements for drug quality standards

Method used

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  • Traditional Chinese medicinal preparation for treating acute upper respiratory infection and preparation method of traditional Chinese medicinal preparation
  • Traditional Chinese medicinal preparation for treating acute upper respiratory infection and preparation method of traditional Chinese medicinal preparation
  • Traditional Chinese medicinal preparation for treating acute upper respiratory infection and preparation method of traditional Chinese medicinal preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] (1) Take 100g of honeysuckle, 430g of mandarin orange, 500g of Sanchaku, 330g of wild chrysanthemum, 290g of Nanlan root, and 860g of plum, add water to decoct, the mass ratio of the weight of water to the components weighed is 10:1, decoct Distilled for 1 to 2 hours, distilled, collected distilled liquid, added 30g β-cyclodextrin to the distilled liquid, mixed to make it completely clathrated, filtered the mixed liquid, dried, and dried at a temperature ≤ 50°C to obtain a solid powder for later use ;

[0043] (2) The aqueous solution after step (1) gained distillation is filtered, and the hydrochloric acid aqueous solution decocting that filter residue adds concentration and is 0.05% v / v, and the mass ratio of hydrochloric acid water and filter residue is 6:1~8:1, and the time of decocting For 1 to 3 hours, filter, then combine the filtrates, concentrate to a relative density of 1.10 to 1.15 at 60°C, add ethanol to make the concentration of ethanol in the combined filt...

Embodiment 2

[0047] (1) Take 104g of honeysuckle, 415g of five-finger mandarin orange, 520g of Sanchaku, 310g of wild chrysanthemum, 310g of Nanlan root, and 835g of plum, add water to decoct, the mass ratio of the weight of water to the components weighed is 10:1, decoct Distilled for 1 to 2 hours, distilled, collected distilled liquid, added 50g of β-cyclodextrin to the distilled liquid, mixed to make it completely clathrated, filtered the mixed liquid, dried, and dried at a temperature of ≤50°C to obtain a solid powder for later use ;

[0048] (2) The aqueous solution after step (1) gained distillation is filtered, and the hydrochloric acid aqueous solution decocting that filter residue adds concentration and is 0.05% v / v, and the mass ratio of hydrochloric acid water and filter residue is 6:1~8:1, and the time of decocting For 1 to 3 hours, filter, then combine the filtrates, concentrate to a relative density of 1.10 to 1.15 at 60°C, add ethanol to make the concentration of ethanol in ...

Embodiment 3

[0052] (1) Take 110g of honeysuckle, 400g of mandarin mandarin orange, 540g of Sanchaku, 290g of wild chrysanthemum, 330g of Nanlan root, and 780g of plum, add water to decoct, the mass ratio of the weight of water to the components weighed is 10:1, decoct Distilled for 1 to 2 hours, distilled, collected distilled liquid, added 32g β-cyclodextrin to the distilled liquid, mixed to make it completely clathrated, filtered the mixed liquid, dried, and dried at a temperature ≤ 50°C to obtain a solid powder for later use ;

[0053] (2) The aqueous solution after step (1) gained distillation is filtered, and the hydrochloric acid aqueous solution decocting that filter residue adds concentration and is 0.05% v / v, and the mass ratio of hydrochloric acid water and filter residue is 6:1~8:1, and the time of decocting For 1 to 3 hours, filter, then combine the filtrates, concentrate to a relative density of 1.10 to 1.15 at 60°C, add ethanol to make the concentration of ethanol in the comb...

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Abstract

The invention discloses a traditional Chinese medicinal preparation for treating acute upper respiratory infection and a preparation method of the traditional Chinese medicinal preparation and belongs to the field of traditional Chinese medicines. The traditional Chinese medicinal preparation for treating the acute upper respiratory infection is prepared from extracts of honeysuckle, folium vilicis negundo, evodia lepta, wild chrysanthemum flower, south isatis root and holly root, acetaminophen, chlorpheniramine maleate, caffeine and beta cyclodextrin. The traditional Chinese medicinal preparation for treating the acute upper respiratory infection is based on basic pathogenesis of wind, warmness, heat and toxin, medicines with dispelling, relieving, eliminating and promoting effects are selected and combined for jointly realizing the effects of dispelling wind, relieving symptoms and clearing away heat and toxic materials, and the traditional Chinese medicinal preparation for treating the acute upper respiratory infection is sucrose-free granules and has the advantages of high stability, low dosage of auxiliary materials and wide application range. The preparation method of the traditional Chinese medicinal preparation for treating the acute upper respiratory infection has the advantage that active ingredients in each component of the traditional Chinese medicinal preparation are distinguished, processed and refined; and the preparation method of the traditional Chinese medicinal preparation for treating the acute upper respiratory infection is simple, has a broad market prospect and is applicable to large scale production.

Description

technical field [0001] The invention relates to a traditional Chinese medicine preparation for treating acute upper respiratory tract infection and a preparation method thereof, belonging to the technical field of traditional Chinese medicines. Background technique [0002] Acute upper respiratory tract infection (AURTI) is a general term for acute inflammation of the nasal cavity, pharynx or larynx, and is the most common respiratory infectious disease. Patients regardless of age, gender, occupation and region. The disease is not only highly contagious, but also can cause serious complications, so it should be actively prevented and treated. The disease can occur throughout the year, with winter and spring as the high incidence period. It can be transmitted through virus-containing droplets or contaminated hands and utensils. It is mostly sporadic, but it can be popular when the climate changes suddenly. Because there are many types of viruses, the human body's immunity t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/754A61K47/40A61P11/00A61P31/04A61P31/12A61P31/16A61K31/167A61K31/4402A61K31/522
Inventor 王波
Owner GUANGXI DOUBLE ANT PHARMA
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