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Application of Sinkiang salvia officinalis extract in preparation of medicines for preventing and treating diabetic nephropathy

A technology of Xinjiang sage, diabetic nephropathy, applied in drug combination, urinary system diseases, metabolic diseases, etc.

Inactive Publication Date: 2015-05-27
XINJIANG MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no report on the prevention and control effect and mechanism of Sage sage in Xinjiang on DN.

Method used

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  • Application of Sinkiang salvia officinalis extract in preparation of medicines for preventing and treating diabetic nephropathy
  • Application of Sinkiang salvia officinalis extract in preparation of medicines for preventing and treating diabetic nephropathy
  • Application of Sinkiang salvia officinalis extract in preparation of medicines for preventing and treating diabetic nephropathy

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Embodiment 1

[0022] The application of the total phenolic acid extract of Xinjiang sage in the preparation of drugs for the prevention and treatment of diabetic nephropathy. The preparation method of the total phenolic acid extract of Xinjiang sage is as follows: adding 25 times the amount of Xinjiang sage to 40% ethanol and refluxing extraction for 3 times , each time for 1 hour, the extracts were combined, and the solvent was recovered to prepare the total phenolic acid extract of Sage sageum Xinjiang.

[0023] The administration dose of the total phenolic acid extract of Sage sageus is 150mg / kg-600mg / kg.

[0024] Verify the experimental content:

[0025] 1. Research content and methods:

[0026] 1.1 Acute toxicity test in mice:

[0027] 1.1.1 Materials and animals:

[0028] 1.1.1.1 Test product:

[0029] According to the optimal extraction process of the total phenolic acids of Sage sageum, the total phenolic acid extract of Sage sageum is prepared as a brown powder, and the require...

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Abstract

The invention discloses an application of a Sinkiang salvia officinalis extract in preparation of medicines for preventing and treating diabetic nephropathy. The application has the beneficial effect that the Sinkiang salvia officinalis extract provided by the invention is applied to preparation of the medicines for preventing and treating diabetic nephropathy. An objective and scientific evaluation is made for the safety of total phenolic acid extracts of Sinkiang salvia officinalis through an experiment; a dosage basis is provided for experiment research for preventing and treating DN (diabetic nephropathy); firstly, the median lethal dose (LD50) is determined through an acute peroral toxicity experiment of mice; on this basis, the preventive and therapeutic effect and possible action mechanism of the total phenolic acid extracts of the Sinkiang salvia officinalis on DN are determined through in vivo experiments on animals; an experiment basis is provided for preventing and treating DN employing natural medicines; and technical data are also provided for further development and utilization.

Description

technical field [0001] The invention relates to the field of medicine preparation, in particular to the application of Xinjiang sage extract in the preparation of medicines for preventing and treating diabetic nephropathy. Background technique [0002] Diabetic nephropathy (DN) is one of the most common and serious microvascular complications of diabetes, a common cause of chronic renal insufficiency, and an important cause of death and disability in diabetic patients. The disease prevention mechanism of DN is relatively complex, how to effectively treat DN is a major problem that researchers are currently facing. There are many reports on the experimental research and clinical application of natural medicines to prevent and treat DN, and attempts to protect DN from molecular biology and gene levels have also been explored. Xinjiang sage (Salvia deserta Schang) is a plant of the Labiatae genus Salvia (Salvia L). The Latin scientific name means desert sage. The roots or rhiz...

Claims

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Application Information

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IPC IPC(8): A61K36/53A61P3/10A61P13/12
Inventor 热娜·卡斯木王晓梅胡君萍王新玲王小青李敏
Owner XINJIANG MEDICAL UNIV
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