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A kind of biological glass-sodium alginate composite biological material and its kit and application

A composite biomaterial, sodium alginate technology, applied in the field of curable bioglass-sodium alginate composite biomaterial and its preparation, can solve the problem of poor clinical operability, long curing time and unsatisfactory antibacterial effect of mineral trioxide aggregates and other issues, to achieve excellent biological activity and biocompatibility, and to promote the formation of

Active Publication Date: 2017-10-27
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, calcium hydroxide has no anti-inflammatory effect and is ineffective for inflamed pulp
[0004] Mineral trioxide aggregates have poor clinical operability, and are difficult to mix and place. The filling process requires the use of some special instruments; the curing time is long, and it needs to be observed for more than 4 hours after pulp capping to ensure that the material is solidified; the price is expensive (both Imported, nearly 1,000 yuan per gram, currently only available in large hospitals), which limits the wide application in clinical practice; the antibacterial effect is not ideal, and only has antibacterial effect on a small number of bacteria

Method used

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  • A kind of biological glass-sodium alginate composite biological material and its kit and application
  • A kind of biological glass-sodium alginate composite biological material and its kit and application
  • A kind of biological glass-sodium alginate composite biological material and its kit and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Step 1: Preparation of bioglass nanospheres

[0033] Using tetraethyl orthosilicate, triethyl phosphate, and calcium nitrate tetrahydrate as raw materials, weigh the corresponding substances in molar ratio, so that the oxides corresponding to each substance in the raw materials are calculated according to the SiO 2 :P 2 o 5 : The molar percentage of CaO was 40:5:55 to prepare bioglass nanospheres. Dissolve 4g of dodecylamine in a mixed solution of 105mL deionized water and absolute ethanol. During the synthesis process, the temperature is controlled at 40°C. After stirring for 10 minutes, 16.00mL of ethyl orthosilicate, 16.32mL of triethyl phosphate, 28.25g Calcium nitrate tetrahydrate, the interval between each feeding is 30min. Stirring was continued for 3 hours after the addition was completed, a white emulsion was obtained, and a wet powder was obtained after centrifugation. The powder is freeze-dried, placed in a box-type electric furnace, and subjected to heat...

Embodiment 2

[0039] According to Example 1, ethyl orthosilicate, triethyl phosphate, and calcium nitrate tetrahydrate are used as raw materials, and the corresponding substances are weighed in molar ratios, so that the oxides corresponding to each substance in the raw materials are calculated according to the SiO 2 :P 2 o 5 : The molar percentage of CaO was 37:8:55 to prepare bioglass nanospheres. The specific operation of Step 1 is the same as that of Embodiment 1.

[0040] Step 2: Preparation of Phosphate Buffered Solidification Solution

[0041] Dipotassium hydrogen phosphate and sodium dihydrogen phosphate are added to a certain amount of water in turn to obtain a phosphate buffer solution. The phosphate concentration was 4M and the pH of the solution was 7.

[0042] Step 3: Preparation of bioglass-sodium alginate composite biomaterial:

[0043]The solid powder prepared above was mixed with the solidification solution at 1.60 g / mL to form a paste. Fill the reconciled paste into a...

Embodiment 3

[0045] According to Example 1, ethyl orthosilicate, triethyl phosphate, and calcium nitrate tetrahydrate are used as raw materials, and the corresponding substances are weighed in molar ratios, so that the oxides corresponding to each substance in the raw materials are calculated according to the SiO 2 :P 2 o 5 : The molar percentage of CaO was 37:8:55 to prepare bioglass nanospheres. The specific operation of Step 1 is the same as that of Embodiment 1.

[0046] Step 2: Preparation of Sodium Alginate Phosphate Buffer Solidification Solution

[0047] Weigh sodium alginate and dissolve it in deionized water to prepare sodium alginate solution. Dipotassium hydrogen phosphate and sodium dihydrogen phosphate were sequentially added to the sodium alginate solution to obtain a 0.5% alginic acid phosphate buffer solution with a phosphate concentration of 4M.

[0048] Step 3: Preparation of bioglass-sodium alginate composite biomaterial:

[0049] The solid powder prepared above wa...

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Abstract

The invention discloses a bioglass-sodium alginate composite biomaterial, a kit and an application. The kit comprises two components: solid powder and a curing liquid, wherein the curing liquid is a phosphate buffer solution and the powder is calcium, phosphorus and silicon ternary bioglass micro-nanospheres, and the proportion of the solid powder to the curing liquid is 1.1-2.0g / mL. A paste blended by the solid powder and the curing liquid can be cured to form the composite biomaterial with certain mechanical strength and hard tissue repairing property. The biomaterial disclosed by the invention is simple in process equipment, easy to operate and low in cost. The prepared composite biomaterial has good bioactivity, degradation rate and certain mechanical strength and can be clinically used for common pulp capping treatment, oral cavity and orthopedic bone defect repair.

Description

technical field [0001] The invention belongs to the field of biomedical repair materials, and relates to a novel curable bioglass-sodium alginate composite biomaterial and its preparation method and application. Background technique [0002] Pulp preservation is an ideal method for treating exposed pulp due to surgical procedures, dental caries, trauma, etc. The ideal pulp capping material should have suitable physical and chemical properties, induce the proliferation and differentiation of dental pulp cells, promote the formation of restorative dentin, have antibacterial and antibacterial properties, and should not cause inflammation of the dental pulp. Currently clinically used pulp capping materials include calcium hydroxide and mineral trioxide aggregates. But neither can fully meet the requirements of pulp capping materials. [0003] Calcium hydroxide is widely used clinically, but calcium hydroxide also has certain side effects and limitations. The strong alkalinity...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K6/097A61K6/02A61L27/10A61L27/20A61K6/898
Inventor 陈晓峰梁绮明胡庆李玉莉李贤
Owner SOUTH CHINA UNIV OF TECH
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