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Method for separating and measuring ticagrelor and optical isomer of ticagrelor

A technology of ticagrelor and diastereoisomers, applied in the field of analytical chemistry, can solve the problem of unretrieved ticagrelor and its diastereoisomer separation and detection method, and no record of ticagrelor Enantiomer analysis methods and other issues

Active Publication Date: 2015-05-20
SUNSHINE LAKE PHARM CO LTD
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  • Description
  • Claims
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Problems solved by technology

At present, "United States Pharmacopoeia" USP, "European Pharmacopoeia" EP, and "Chinese Pharmacopoeia" Ch.P do not record the analysis method of ticagrelor diastereoisomers, and no relevant literature reports about ticagrelor and Separation and detection method of its diastereoisomers

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  • Method for separating and measuring ticagrelor and optical isomer of ticagrelor
  • Method for separating and measuring ticagrelor and optical isomer of ticagrelor

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Embodiment Construction

[0011] In order to more accurately control the content of diastereoisomers in the product and ensure the quality of raw materials and preparations, the inventor has developed a product suitable for ticagrelor and its diastereoisomers through repeated tests and research. Analytical methods for content determination. The method of the invention can separate and detect ticagrelor and its diastereomers simply, quickly and accurately.

[0012] The object of the present invention is to provide a method for the separation and determination of ticagrelor and its diastereomeric impurities by liquid chromatography, thereby realizing the separation and determination of ticagrelor and its diastereomeric impurities .

[0013] A method for the separation and determination of ticagrelor and its diastereoisomers by liquid chromatography, characterized in that a chiral chromatographic column with polysaccharide derivatives as filler is used, and a mixed solution of lower alkanes and lower alc...

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Abstract

The invention belongs to the field of analytical chemistry and in particular relates to a method for separating and measuring ticagrelor and a diastereoisomer of the ticagrelor. The method is characterized in that a chiral HPLC (High Performance Liquid Chromatography) column taking polysaccharide derivative as a filler is used and a mixed solution of lower paraffin hydrocarbon and low alcohol is used as a moving phase; according to the separating and detecting method, the ticagrelor and the diastereoisomer of the ticagrelor are effectively separated, and the mass of the ticagrelor can be effectively controlled. The method can be used for separating and detecting the ticagrelor and the diastereoisomer of the ticagrelor simply, rapidly and accurately.

Description

technical field [0001] The invention relates to the field of analytical chemistry, in particular to a method for separating and measuring ticagrelor and its diastereoisomers by liquid chromatography. Background technique [0002] Ticagrelor (Ticagrelor), the chemical name is (1S,2S,3R,5S)-3-(7-((1R,2S)-2-(3,4-difluorophenyl)cyclopropylamino)- 5-(Propylthio)-3H-[1,2,3]triazol[4,5-d]pyrimidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2 -diol), its chemical structure is as shown in formula (I), [0003] [0004] Ticagrelor is a new type of cyclopentyltriazole pyrimidine (CPTP) oral anti-platelet aggregation drug developed by AstraZeneca, which can reversibly bind to P2Y ADP receptor and inhibit ADP-mediated Platelet aggregation has obvious inhibitory effect, can reduce the incidence of cardiovascular diseases such as heart disease, and reduce the mortality rate of patients with acute coronary syndrome. [0005] (1R,2S)-2-(3,4-difluorophenyl)cyclopropylamine, as shown in for...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02G01N30/06
Inventor 马培丽周佩媚饶万兵刘国柱刘瑞娟王海龙
Owner SUNSHINE LAKE PHARM CO LTD
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