Microencapsulated multivesicular liposome drug carrier and preparation method thereof

Abstract

The invention provides a microencapsulated multivesicular liposome drug carrier and a preparation method thereof. The method comprises the following steps: with a sucrose solution as an inner water phase, glucose and an L-lysine solution as outer water phases, and a dichloromethane solution dissolved with lipid as an oil phase, carrying out high-speed homogenate emulsification on the inner water phase and the oil phase to form colostrums; adding the outer water phase, carrying out vortex emulsification to form a compound emulsion, carrying out rotary evaporation to remove dichloromethane, so as to obtain a multivesicular liposome suspension; dispersing the multivesicular liposome into a sodium alginate solution, dispersing uniformly, and then dropping into a calcium chloride solution through a high-pressure microcapsule molding device and an injection pump, so as to prepare calcium alginate gel beads embedded with the multivesicular liposome; and finally forming a film from the gel beads and a cationic polymer solution, so as to form a sample, wherein the drug is carried on at least one part in the multivesicular liposome or out of the multivesicular liposome in the microcapsule. According to the microencapsulated multivesicular liposome drug carrier, space allocation of different drugs is ensured; the long-acting release and absorption of the drug are improved; and toxic and side effects caused by simple use of the drug are reduced.

Description

【Technical field】 [0001] The invention relates to a microcapsule-embedded multivesicle liposome drug carrier and a preparation method thereof. 【Background technique】 [0002] In recent years, microcapsules / spheres and other particulate drug sustained-release systems have developed rapidly and have been widely used clinically. In addition, for many diseases, such as cancer, AIDS, malaria, multiple sclerosis, hypertension, etc., single drug therapy and drug sustained release system often cannot achieve the desired therapeutic effect, and drug combination therapy can pass through the diseased cells. Modulate different signaling pathways to maximize therapeutic effect. Therefore, combined with drug combination therapy and drug carrier system to achieve slow / controlled release of drugs, it can reduce the frequency of drug application and alleviate the suffering of patients. However, at present, drug sustained-release microcapsules / spheres often face problems such as drug burst ...

AI Technical Summary

Problems solved by technology

At the same time, due to the differences in physical and chemical properties between different drugs, they may face problems such as drug cross-contamination when mixed in drug carriers

[0003] In addition, liposome-based drug carriers usually have good biocompatibility but are not very stable, while polymer-based drug carriers usually have good stability but poor biocompatibility.