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Capsule skin of a chewable soft capsule with immune enhancing effect and soft capsule prepared therefrom

A technology for enhancing immunity and soft capsules is applied in the directions of medical preparations of non-active ingredients, capsule delivery, and food forming, etc., which can solve the problems of insufficient application, affecting the shelf life of products, and unsatisfactory chewability. Achieve synergistic moisturizing, dissolving and diffusion, balancing odor and content taste, and novel formula composition.

Active Publication Date: 2018-05-11
安徽墨药集团有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Existing soft capsules and their preparation have the following deficiencies: (1) the chewability is not ideal, and the stability is relatively poor; at present, it is mainly increased by adding plasticizers, polymer modifiers and water to the formula. Its chewing performance, for example, US Patent US6280767 discloses a chewable soft capsule, which keeps the capsule soft by increasing the amount of plasticizer, wherein gelatin in the rubber prescription: plasticizer=100:100~600 ; U.S. Patent US20050136104 discloses a chewable soft capsule, which keeps the capsule soft by maintaining a high moisture content, wherein the water content in the rubber is as high as 27%; patent WO2011014942 discloses a chewable soft capsule , the soft capsule maintains a certain softness and water-locking property by adding 10-20% starch in the rubber, so that the rubber is easy to chew; although the above-mentioned technology can obtain a certain improvement in its chewing performance and rubber softness, but At the same time, it will also cause the soft capsules to be deformed or bonded due to mutual extrusion, thereby affecting the shelf life of the product; (2) The taste is not good; due to the smell of the rubber itself, and the content accounts for 60-90% of the weight of the whole capsule , the bad smell of some raw materials in the content will greatly affect the taste when people take it
In the prior art, β-glucan is mainly used as a moisturizing agent in the preparation process of soft capsules, and its effect of improving immunity has not been fully applied

Method used

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  • Capsule skin of a chewable soft capsule with immune enhancing effect and soft capsule prepared therefrom
  • Capsule skin of a chewable soft capsule with immune enhancing effect and soft capsule prepared therefrom

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Example 1 A capsule skin of a chewable soft capsule with an immune-enhancing effect is prepared from the following mass ratio components: gelatin with a freezing strength of 150: glycerin: purified water: sweetener (crystallized fructose): natural flavoring agent ( Apple extract): β-glucan (molecular weight 50kD)=30:15:30:10:1:1:

[0027] (1) Dissolve the natural flavoring agent in purified water with an amount of 15% purified water, mix well, heat to 30~32°C, add β-glucan, continue to stir for 10 minutes, and then place it under ultrasonic wave with a frequency of 60KHz for ultrasonic treatment 15mim, to get β-glucan solution;

[0028] (2) Set the jacket temperature of the chemical tank to 65°C to heat the chemical tank, add glycerin, remaining purified water, and sweetener to the chemical tank, turn on the electric stirring for 25 minutes until the materials are evenly dissolved, and then add β-glucan solution , continue to stir for 10 minutes;

[0029] (3) When the...

Embodiment 2

[0032] Example 2 The capsule skin of a chewable soft capsule with an immune-enhancing effect is prepared from the following mass ratio components: gelatin with a freezing strength of 200: glycerin: purified water: sweetener (steviol glycoside): natural flavoring agent ( Blueberry powder, black currant powder): β-glucan (molecular weight 1000kD)=25:20:25:11:1.8:0.5:

[0033] (1) Dissolve the natural flavoring agent in purified water with 20% purified water, mix well, heat to 30~32°C, add β-glucan, continue to stir for 5 minutes, and then place it under ultrasonic wave with a frequency of 55KHz for ultrasonic treatment 22mim, to get β-glucan solution;

[0034] (2) Set the jacket temperature of the chemical tank to 65°C to heat the chemical tank, add glycerin, remaining purified water, and sweetener to the chemical tank, stir for 15 minutes until the materials are evenly dissolved, add β-glucan solution, and continue Stir for 10 minutes;

[0035] (3) When the temperature of the...

Embodiment 3

[0038] Example 3 Preparation of Chewable Soft Capsules

[0039] 1. Capsule skin preparation: prepared from the following mass ratio components: gelatin with a freezing strength of 80: glycerin: purified water: sweetener (xylitol): natural flavoring agent (sweet orange powder): β-glucan (Molecular weight 500kD)=35:10:35:5:0.5:2.5:

[0040] (1) Dissolve the natural flavoring agent in purified water with an amount of 18% purified water, mix well, heat to 30~32°C, add β-glucan, continue to stir for 8 minutes, and then place it under ultrasonic wave with a frequency of 55KHz for ultrasonic treatment 20mim, to get β-glucan solution;

[0041] (2) Set the jacket temperature of the chemical tank to 65°C to heat the chemical tank, add glycerin, remaining purified water, and sweetener to the chemical tank, stir for 20 minutes until the materials are evenly dissolved, add β-glucan solution, and continue Stir for 5 minutes;

[0042] (3) When the material temperature in the chemical tank...

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Abstract

The invention discloses a capsule skin of a chewable soft capsule with immune enhancing effect and a soft capsule prepared therefrom. The capsule skin of the present invention is composed of gelatin, glycerin, purified water, sweetener, natural flavoring agent, and β-glucan according to the mass ratio of 25~35:10~20:25~35:5~15:0.5~ 3: 0.5~5 preparation; during preparation, the flavoring agent is first dissolved in purified water and then blended with β-glucan, ultrasonically treated, and then the ultrasonicated β-glucan solution is mixed with the rest of the components, dissolved , melt glue, make glue solution, adopt conventional process to make capsule skin with this glue solution again. With the formulation of the capsule skin of the present invention, the capsule skin obtained by the preparation method has high chewability, stability, and moisture retention. Ultrasonic treatment can also balance the smell of the rubber skin and the taste of the contents, and exert the enhancement of β-glucan. Immunity function, the chewable soft capsule prepared with the capsule skin has good softness, chewiness and mouthfeel, and after the soft capsule is broken, the capsule skin can be quickly dissolved or dispersed, and is easy to swallow.

Description

technical field [0001] The invention relates to a capsule skin of a chewable soft capsule, in particular to a capsule skin of a chewable soft capsule with an immune-enhancing effect and a soft capsule prepared therefrom, belonging to the technical field of medicine, food, health food or pharmacy. Background technique [0002] Chewable soft capsules are soft capsules that can be chewed. Compared with traditional capsule preparations, chewable soft capsules have good chewability and are easy to take. They are popular with the elderly, children and patients who are difficult to swallow traditional soft capsules. like. [0003] With the development of technology, chewable soft capsules are gradually moving closer to the field of health care products and are used in many fields. Existing soft capsules and their preparation have the following deficiencies: (1) the chewability is not ideal, and the stability is relatively poor; at present, it is mainly increased by adding plastici...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/48A61K47/36A23P10/30
Inventor 梅丹陈文俊
Owner 安徽墨药集团有限公司
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